The PaO2/FiO2 is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database Article Swipe
Hongying Bi
,
Xu Liu
,
Chi Chen
,
Lu Chen
,
Xian Liu
,
Jianmin Zhong
,
Yan Tang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12890-023-02491-8
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12890-023-02491-8
Background To clarify the relationship between the PaO 2 /FiO 2 and 28-day mortality in patients with sepsis. Methods This was a retrospective cohort study regarding MIMIC-IV database. Nineteen thousand two hundred thirty-three patients with sepsis were included in the final analysis. PaO 2 /FiO 2 was exposure variable, 28-day mortality was outcome variable. PaO 2 /FiO 2 was log-transformed as LnPaO 2 /FiO 2 . Binary logistic regression was used to explore the independent effects of LnPaO 2 /FiO 2 on 28-day mortality using non-adjusted and multivariate-adjusted models. A generalized additive model (GAM) and smoothed curve fitting was used to investigate the non-linear relationship between LnPaO 2 /FiO 2 and 28-day mortality. A two-piecewise linear model was used to calculate the OR and 95% CI on either side of the inflection point. Results The relationship between LnPaO 2 /FiO 2 and risk of 28-day death in sepsis patients was U-shape. The inflection point of LnPaO 2 /FiO 2 was 5.30 (95%CI: 5.21—5.39), which indicated the inflection point of PaO 2 /FiO 2 was 200.33 mmHg (95%CI: 183.09 mmHg—219.20 mmHg). On the left of inflection point, LnPaO 2 /FiO 2 was negatively correlated with 28-day mortality (OR: 0.37, 95%CI: 0.32—0.43, p < 0.0001). On the right of inflection point, LnPaO 2 /FiO 2 was positively correlated with 28-day mortality in patients with sepsis (OR: 1.53, 95%CI: 1.31—1.80, p < 0.0001). Conclusions In patients with sepsis, either a high or low PaO 2 /FiO 2 was associated with an increased risk of 28-day mortality. In the range of 183.09 mmHg to 219.20 mmHg, PaO 2 /FiO 2 was associated with a lower risk of 28-day death in patients with sepsis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12890-023-02491-8
- https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/s12890-023-02491-8
- OA Status
- gold
- Cited By
- 8
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4378573962
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4378573962Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12890-023-02491-8Digital Object Identifier
- Title
-
The PaO2/FiO2 is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV databaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-05-27Full publication date if available
- Authors
-
Hongying Bi, Xu Liu, Chi Chen, Lu Chen, Xian Liu, Jianmin Zhong, Yan TangList of authors in order
- Landing page
-
https://doi.org/10.1186/s12890-023-02491-8Publisher landing page
- PDF URL
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https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/s12890-023-02491-8Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/s12890-023-02491-8Direct OA link when available
- Concepts
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Medicine, Sepsis, Retrospective cohort study, Database, Intensive care medicine, Emergency medicine, Internal medicine, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 4Per-year citation counts (last 5 years)
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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