The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases Article Swipe
Sedigheh Jalali
,
Ali Farhadi
,
Gholamreza Rafiei Dehbidi
,
Shirin Farjadian
,
Sedigheh Sharifzadeh
,
Reza Ranjbaran
,
Noorossadat Seyyedi
,
Sepide Namdari
,
Abbas Behzad‐Behbahani
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/1639990
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/1639990
Background. The nonstructural protein (NS1) of human parvovirus B19 (hPVB19) is considered to be a double-edged sword in its pathogenesis. NS1 protein promotes cell death by apoptosis in erythroid-lineage cells and is also implicated in triggering and the progression of various inflammation and autoimmune disorders. Objectives. We investigated the possible role of hPVB19 NS1 in the modulation of proinflammatory cytokines in nonpermissive HEK-293T cells. Methods. A plasmid containing the fully sequenced NS1 gene (pCMV6-AC-GFP-NS1) was transfected into HEK-293T cells. Transfection efficiency was assessed by fluorescent microscopy over time. Mock (pCMV6-AC-GFP) transfected cells were used as controls. The percentage of apoptotic cells was measured by flow cytometry at 24, 48, and 72 h posttransfection. Interleukin 6 (IL-6) mRNA, as a pleiotropic cytokine, was measured by real-time PCR. Furthermore, cellular supernatants were collected to determine the type and quantity of cytokines produced by mock- and NS1-transfected cells using flow cytometry. Results. Fold change in the expression level of IL-6 mRNA in transfected cells after 72 hr of incubation was found to be 3.01 when compared with mock-transfected cells; however, cell apoptosis did not happen over time. Also, the concentration of cytokines such as IL-2, IL-6, IL-9, IL-17A, IL-21, IL-22, interferon (IFN)-γ, and tumor necrosis factor α (TNF-α) increased in NS1-transfected cells. Conclusions. Overall, our results indicated that proinflammatory cytokine levels had increased following the expression of hPVB19 NS1 in HEK-293T cells, consistent with a role for NS1 expression facilitating the upregulation of inflammatory reactions. Therefore, hPVB19 NS1 function may play a role in the progression of some chronic and inflammatory diseases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2022/1639990
- https://downloads.hindawi.com/journals/ipid/2022/1639990.pdf
- OA Status
- gold
- Cited By
- 10
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285742998
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285742998Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2022/1639990Digital Object Identifier
- Title
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The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory DiseasesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-06-06Full publication date if available
- Authors
-
Sedigheh Jalali, Ali Farhadi, Gholamreza Rafiei Dehbidi, Shirin Farjadian, Sedigheh Sharifzadeh, Reza Ranjbaran, Noorossadat Seyyedi, Sepide Namdari, Abbas Behzad‐BehbahaniList of authors in order
- Landing page
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https://doi.org/10.1155/2022/1639990Publisher landing page
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https://downloads.hindawi.com/journals/ipid/2022/1639990.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://downloads.hindawi.com/journals/ipid/2022/1639990.pdfDirect OA link when available
- Concepts
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Medicine, Parvovirus, Immunology, Inflammation, Bioinformatics, Virology, Biology, VirusTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 4, 2024: 2, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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