The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO study Article Swipe
Sophie. Spencer
,
Samantha A. Harker
,
Fatoumata Barry
,
Jennifer Beauchemin
,
B. Blair Braden
,
Phoebe Burton
,
Viren D’Sa
,
Daphne Koinis‐Mitchell
,
Sarah E. Mennenga
,
Sean Deoni
,
Candace R. Lewis
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4139933/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4139933/v1
Epigenetic processes, including DNA methylation, are emerging as key areas of interest for their potential roles as biomarkers and contributors to the risk of neurodevelopmental, psychiatric, and other brain-based disorders. Despite this growing focus, there remains a notable gap in our understanding of how DNA methylation correlates with individual variations in brain function and structure. Additionally, the dynamics of these relationships during developmental periods, which are critical windows during which many disorders first appear, are still largely unexplored. The current study extends the field by examining if peripheral DNA methylation of myelination-related genes predicts white matter volume in a healthy pediatric population [N = 250; females = 113; age range 2 months-14 years; M age = 5.14, SD age = 3.60]. We assessed if DNA methylation of 17 myelin-related genes predict white matter volume and if age moderates these relationships. Results highlight low variability in myelin-related epigenetic variance at birth, which rapidly increases non-linearly with age, and that DNA methylation, measured at both the level of a CpG site or gene, is highly predictive of white matter volume, in early childhood but not late childhood. These novel findings propel the field forward by establishing that DNA methylation of myelin-related genes from a peripheral tissue is a predictive marker of white matter volume in children and is influenced by developmental stage. The research underscores the significance of peripheral epigenetic patterns as a proxy for investigating the effects of environmental factors, behaviors, and disorders associated with white matter.
Related Topics
Concepts
Epigenome
Echo (communications protocol)
Peripheral
Volume (thermodynamics)
White matter
Stage (stratigraphy)
Psychology
Neuroscience
Biology
Computer science
Physics
Internal medicine
Medicine
Genetics
DNA methylation
Computer security
Magnetic resonance imaging
Quantum mechanics
Gene expression
Gene
Radiology
Paleontology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4139933/v1
- https://www.researchsquare.com/article/rs-4139933/latest.pdf
- OA Status
- green
- Cited By
- 2
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394951301
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394951301Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-4139933/v1Digital Object Identifier
- Title
-
The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO studyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-19Full publication date if available
- Authors
-
Sophie. Spencer, Samantha A. Harker, Fatoumata Barry, Jennifer Beauchemin, B. Blair Braden, Phoebe Burton, Viren D’Sa, Daphne Koinis‐Mitchell, Sarah E. Mennenga, Sean Deoni, Candace R. LewisList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-4139933/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-4139933/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-4139933/latest.pdfDirect OA link when available
- Concepts
-
Epigenome, Echo (communications protocol), Peripheral, Volume (thermodynamics), White matter, Stage (stratigraphy), Psychology, Neuroscience, Biology, Computer science, Physics, Internal medicine, Medicine, Genetics, DNA methylation, Computer security, Magnetic resonance imaging, Quantum mechanics, Gene expression, Gene, Radiology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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