The pharmacoepigenetic paradigm in cancer treatment Article Swipe
Belén Ocaña-Paredes
,
Sebastián Rivera-Orellana
,
David Ramírez
,
Juliana Montalvo-Guerrero
,
María Paula Freire
,
Samantha Espinoza-Ferrao
,
Adriana Altamirano-Colina
,
Paulina Echeverría-Espinoza
,
María José Ramos-Medina
,
Gabriela Echeverría‐Garcés
,
Danilo Granda-Moncayo
,
Andrea Jácome-Alvarado
,
María Gabriela Andrade
,
Andrés López-Cortés
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1381168
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1381168
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight has led to the development of a novel class of therapeutic agents, known as epigenetic drugs. These drugs, including histone deacetylase inhibitors, histone acetyltransferase inhibitors, histone methyltransferase inhibitors, and DNA methyltransferase inhibitors, aim to modulate gene expression to curb cancer growth by uniquely altering the epigenetic landscape of cancer cells. Ongoing research and clinical trials are rigorously evaluating the efficacy of these drugs, particularly their ability to improve therapeutic outcomes when used in combination with other treatments. Such combination therapies may more effectively target cancer and potentially overcome the challenge of drug resistance, a significant hurdle in cancer therapy. Additionally, the importance of nutrition, inflammation control, and circadian rhythm regulation in modulating drug responses has been increasingly recognized, highlighting their role as critical modifiers of the epigenetic landscape and thereby influencing the effectiveness of pharmacological interventions and patient outcomes. Epigenetic drugs represent a paradigm shift in cancer treatment, offering targeted therapies that promise a more precise approach to treating a wide spectrum of tumors, potentially with fewer side effects compared to traditional chemotherapy. This progress marks a step towards more personalized and precise interventions, leveraging the unique epigenetic profiles of individual tumors to optimize treatment strategies.
Related Topics
Concepts
Epigenetics
Histone deacetylase
Cancer
Medicine
Vorinostat
Bioinformatics
Epigenetic therapy
Methyltransferase
Biology
Histone
DNA methylation
Pharmacology
Gene
Gene expression
Genetics
Internal medicine
Methylation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2024.1381168
- OA Status
- gold
- Cited By
- 15
- References
- 173
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395079372
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4395079372Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2024.1381168Digital Object Identifier
- Title
-
The pharmacoepigenetic paradigm in cancer treatmentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-24Full publication date if available
- Authors
-
Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría‐Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-CortésList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2024.1381168Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fphar.2024.1381168Direct OA link when available
- Concepts
-
Epigenetics, Histone deacetylase, Cancer, Medicine, Vorinostat, Bioinformatics, Epigenetic therapy, Methyltransferase, Biology, Histone, DNA methylation, Pharmacology, Gene, Gene expression, Genetics, Internal medicine, MethylationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 5Per-year citation counts (last 5 years)
- References (count)
-
173Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4395079372 |
|---|---|
| doi | https://doi.org/10.3389/fphar.2024.1381168 |
| ids.doi | https://doi.org/10.3389/fphar.2024.1381168 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38720770 |
| ids.openalex | https://openalex.org/W4395079372 |
| fwci | 7.20370838 |
| type | article |
| title | The pharmacoepigenetic paradigm in cancer treatment |
| biblio.issue | |
| biblio.volume | 15 |
| biblio.last_page | 1381168 |
| biblio.first_page | 1381168 |
| topics[0].id | https://openalex.org/T11736 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Histone Deacetylase Inhibitors Research |
| topics[1].id | https://openalex.org/T10269 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9998000264167786 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Epigenetics and DNA Methylation |
| topics[2].id | https://openalex.org/T10587 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9678000211715698 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autophagy in Disease and Therapy |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C41091548 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8279526233673096 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q26939 |
| concepts[0].display_name | Epigenetics |
| concepts[1].id | https://openalex.org/C2778305200 |
| concepts[1].level | 4 |
| concepts[1].score | 0.6683598160743713 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q174378 |
| concepts[1].display_name | Histone deacetylase |
| concepts[2].id | https://openalex.org/C121608353 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5107517242431641 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[2].display_name | Cancer |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4849100708961487 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C2776262904 |
| concepts[4].level | 5 |
| concepts[4].score | 0.45705366134643555 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q905901 |
| concepts[4].display_name | Vorinostat |
| concepts[5].id | https://openalex.org/C60644358 |
| concepts[5].level | 1 |
| concepts[5].score | 0.44161540269851685 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[5].display_name | Bioinformatics |
| concepts[6].id | https://openalex.org/C2780737395 |
| concepts[6].level | 5 |
| concepts[6].score | 0.4314751625061035 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q18353741 |
| concepts[6].display_name | Epigenetic therapy |
| concepts[7].id | https://openalex.org/C91965660 |
| concepts[7].level | 4 |
| concepts[7].score | 0.42493557929992676 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q415875 |
| concepts[7].display_name | Methyltransferase |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.42044761776924133 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C64927066 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4013080894947052 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q36293 |
| concepts[9].display_name | Histone |
| concepts[10].id | https://openalex.org/C190727270 |
| concepts[10].level | 4 |
| concepts[10].score | 0.3407188653945923 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[10].display_name | DNA methylation |
| concepts[11].id | https://openalex.org/C98274493 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3241056799888611 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[11].display_name | Pharmacology |
| concepts[12].id | https://openalex.org/C104317684 |
| concepts[12].level | 2 |
| concepts[12].score | 0.21447795629501343 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[12].display_name | Gene |
| concepts[13].id | https://openalex.org/C150194340 |
| concepts[13].level | 3 |
| concepts[13].score | 0.20750078558921814 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[13].display_name | Gene expression |
| concepts[14].id | https://openalex.org/C54355233 |
| concepts[14].level | 1 |
| concepts[14].score | 0.15398907661437988 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[14].display_name | Genetics |
| concepts[15].id | https://openalex.org/C126322002 |
| concepts[15].level | 1 |
| concepts[15].score | 0.13624322414398193 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[15].display_name | Internal medicine |
| concepts[16].id | https://openalex.org/C33288867 |
| concepts[16].level | 3 |
| concepts[16].score | 0.06906983256340027 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[16].display_name | Methylation |
| keywords[0].id | https://openalex.org/keywords/epigenetics |
| keywords[0].score | 0.8279526233673096 |
| keywords[0].display_name | Epigenetics |
| keywords[1].id | https://openalex.org/keywords/histone-deacetylase |
| keywords[1].score | 0.6683598160743713 |
| keywords[1].display_name | Histone deacetylase |
| keywords[2].id | https://openalex.org/keywords/cancer |
| keywords[2].score | 0.5107517242431641 |
| keywords[2].display_name | Cancer |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.4849100708961487 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/vorinostat |
| keywords[4].score | 0.45705366134643555 |
| keywords[4].display_name | Vorinostat |
| keywords[5].id | https://openalex.org/keywords/bioinformatics |
| keywords[5].score | 0.44161540269851685 |
| keywords[5].display_name | Bioinformatics |
| keywords[6].id | https://openalex.org/keywords/epigenetic-therapy |
| keywords[6].score | 0.4314751625061035 |
| keywords[6].display_name | Epigenetic therapy |
| keywords[7].id | https://openalex.org/keywords/methyltransferase |
| keywords[7].score | 0.42493557929992676 |
| keywords[7].display_name | Methyltransferase |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.42044761776924133 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/histone |
| keywords[9].score | 0.4013080894947052 |
| keywords[9].display_name | Histone |
| keywords[10].id | https://openalex.org/keywords/dna-methylation |
| keywords[10].score | 0.3407188653945923 |
| keywords[10].display_name | DNA methylation |
| keywords[11].id | https://openalex.org/keywords/pharmacology |
| keywords[11].score | 0.3241056799888611 |
| keywords[11].display_name | Pharmacology |
| keywords[12].id | https://openalex.org/keywords/gene |
| keywords[12].score | 0.21447795629501343 |
| keywords[12].display_name | Gene |
| keywords[13].id | https://openalex.org/keywords/gene-expression |
| keywords[13].score | 0.20750078558921814 |
| keywords[13].display_name | Gene expression |
| keywords[14].id | https://openalex.org/keywords/genetics |
| keywords[14].score | 0.15398907661437988 |
| keywords[14].display_name | Genetics |
| keywords[15].id | https://openalex.org/keywords/internal-medicine |
| keywords[15].score | 0.13624322414398193 |
| keywords[15].display_name | Internal medicine |
| keywords[16].id | https://openalex.org/keywords/methylation |
| keywords[16].score | 0.06906983256340027 |
| keywords[16].display_name | Methylation |
| language | en |
| locations[0].id | doi:10.3389/fphar.2024.1381168 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S132108250 |
| locations[0].source.issn | 1663-9812 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1663-9812 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Pharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Pharmacology |
| locations[0].landing_page_url | https://doi.org/10.3389/fphar.2024.1381168 |
| locations[1].id | pmid:38720770 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in pharmacology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38720770 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11076712 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Front Pharmacol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11076712 |
| locations[3].id | pmh:oai:doaj.org/article:6aeb0f23da1d4129ad4c7d906668331a |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Frontiers in Pharmacology, Vol 15 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5093486024 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Belén Ocaña-Paredes |
| authorships[0].countries | EC |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[0].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[0].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[0].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[0].institutions[0].country_code | EC |
| authorships[0].institutions[0].display_name | Universidad de Las Américas |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Belén Ocaña-Paredes |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[1].author.id | https://openalex.org/A5095856600 |
| authorships[1].author.orcid | https://orcid.org/0009-0003-3119-9817 |
| authorships[1].author.display_name | Sebastián Rivera-Orellana |
| authorships[1].countries | EC |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I5459901 |
| authorships[1].affiliations[0].raw_affiliation_string | Facultad de Ingenierías y Ciencias Aplicadas, Universidad Internacional SEK, Quito, Ecuador. |
| authorships[1].institutions[0].id | https://openalex.org/I5459901 |
| authorships[1].institutions[0].ror | https://ror.org/00nk5y742 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I5459901 |
| authorships[1].institutions[0].country_code | EC |
| authorships[1].institutions[0].display_name | Universidad Internacional SEK |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sebastián Rivera-Orellana |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Facultad de Ingenierías y Ciencias Aplicadas, Universidad Internacional SEK, Quito, Ecuador. |
| authorships[2].author.id | https://openalex.org/A5046962908 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0002-1189 |
| authorships[2].author.display_name | David Ramírez |
| authorships[2].countries | EC |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[2].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[2].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[2].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[2].institutions[0].country_code | EC |
| authorships[2].institutions[0].display_name | Universidad de Las Américas |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | David Ramírez-Sánchez |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[3].author.id | https://openalex.org/A5095856601 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Juliana Montalvo-Guerrero |
| authorships[3].countries | EC |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[3].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[3].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[3].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[3].institutions[0].country_code | EC |
| authorships[3].institutions[0].display_name | Universidad de Las Américas |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Juliana Montalvo-Guerrero |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[4].author.id | https://openalex.org/A5109777369 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | María Paula Freire |
| authorships[4].countries | EC |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[4].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[4].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[4].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[4].institutions[0].country_code | EC |
| authorships[4].institutions[0].display_name | Universidad de Las Américas |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | María Paula Freire |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[5].author.id | https://openalex.org/A5104213494 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Samantha Espinoza-Ferrao |
| authorships[5].countries | EC |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[5].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[5].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[5].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[5].institutions[0].country_code | EC |
| authorships[5].institutions[0].display_name | Universidad de Las Américas |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Samantha Espinoza-Ferrao |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[6].author.id | https://openalex.org/A5111179738 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Adriana Altamirano-Colina |
| authorships[6].countries | EC |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[6].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[6].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[6].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[6].institutions[0].country_code | EC |
| authorships[6].institutions[0].display_name | Universidad de Las Américas |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Adriana Altamirano-Colina |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[7].author.id | https://openalex.org/A5111179739 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Paulina Echeverría-Espinoza |
| authorships[7].countries | EC |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[7].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[7].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[7].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[7].institutions[0].country_code | EC |
| authorships[7].institutions[0].display_name | Universidad de Las Américas |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Paulina Echeverría-Espinoza |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[8].author.id | https://openalex.org/A5063694340 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | María José Ramos-Medina |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I17937529, https://openalex.org/I223822909 |
| authorships[8].affiliations[0].raw_affiliation_string | German Cancer Research Center (DKFZ), Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. |
| authorships[8].institutions[0].id | https://openalex.org/I17937529 |
| authorships[8].institutions[0].ror | https://ror.org/04cdgtt98 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | German Cancer Research Center |
| authorships[8].institutions[1].id | https://openalex.org/I223822909 |
| authorships[8].institutions[1].ror | https://ror.org/038t36y30 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I223822909 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | Heidelberg University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | María José Ramos-Medina |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | German Cancer Research Center (DKFZ), Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. |
| authorships[9].author.id | https://openalex.org/A5022645055 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-1941-7864 |
| authorships[9].author.display_name | Gabriela Echeverría‐Garcés |
| authorships[9].countries | EC |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210105464 |
| authorships[9].affiliations[0].raw_affiliation_string | Centro de Referencia Nacional de Genómica, Secuenciación y Bioinformática, Instituto Nacional de Investigación en Salud Pública "Leopoldo Izquieta Pérez", Quito, Ecuador. |
| authorships[9].affiliations[1].raw_affiliation_string | Latin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. |
| authorships[9].institutions[0].id | https://openalex.org/I4210105464 |
| authorships[9].institutions[0].ror | https://ror.org/00zma5460 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210105464 |
| authorships[9].institutions[0].country_code | EC |
| authorships[9].institutions[0].display_name | Instituto Nacional de Investigación en Salud Pública |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Gabriela Echeverría-Garcés |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Centro de Referencia Nacional de Genómica, Secuenciación y Bioinformática, Instituto Nacional de Investigación en Salud Pública "Leopoldo Izquieta Pérez", Quito, Ecuador., Latin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. |
| authorships[10].author.id | https://openalex.org/A5104723629 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Danilo Granda-Moncayo |
| authorships[10].countries | PH |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I193207422 |
| authorships[10].affiliations[0].raw_affiliation_string | Deutsche Gesellschaft für Internationale Zusammenarbeit Gmbh, Quito, Ecuador. |
| authorships[10].institutions[0].id | https://openalex.org/I193207422 |
| authorships[10].institutions[0].ror | https://ror.org/00m42s140 |
| authorships[10].institutions[0].type | other |
| authorships[10].institutions[0].lineage | https://openalex.org/I193207422, https://openalex.org/I4210095035 |
| authorships[10].institutions[0].country_code | PH |
| authorships[10].institutions[0].display_name | Deutsche Gesellschaft für Internationale Zusammenarbeit |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Danilo Granda-Moncayo |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Deutsche Gesellschaft für Internationale Zusammenarbeit Gmbh, Quito, Ecuador. |
| authorships[11].author.id | https://openalex.org/A5027026478 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4993-6718 |
| authorships[11].author.display_name | Andrea Jácome-Alvarado |
| authorships[11].countries | EC |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[11].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[11].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[11].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[11].institutions[0].country_code | EC |
| authorships[11].institutions[0].display_name | Universidad de Las Américas |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Andrea Jácome-Alvarado |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[12].author.id | https://openalex.org/A5110440492 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | María Gabriela Andrade |
| authorships[12].countries | EC |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[12].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[12].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[12].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[12].institutions[0].country_code | EC |
| authorships[12].institutions[0].display_name | Universidad de Las Américas |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | María Gabriela Andrade |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[13].author.id | https://openalex.org/A5111179737 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Andrés López-Cortés |
| authorships[13].countries | EC |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210102282 |
| authorships[13].affiliations[0].raw_affiliation_string | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| authorships[13].institutions[0].id | https://openalex.org/I4210102282 |
| authorships[13].institutions[0].ror | https://ror.org/0198j4566 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210102282 |
| authorships[13].institutions[0].country_code | EC |
| authorships[13].institutions[0].display_name | Universidad de Las Américas |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | Andrés López-Cortés |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fphar.2024.1381168 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The pharmacoepigenetic paradigm in cancer treatment |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11736 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Histone Deacetylase Inhibitors Research |
| related_works | https://openalex.org/W3151757475, https://openalex.org/W1483077634, https://openalex.org/W2145470144, https://openalex.org/W4200528065, https://openalex.org/W3023264035, https://openalex.org/W1513102126, https://openalex.org/W2345149559, https://openalex.org/W2516856182, https://openalex.org/W2184344430, https://openalex.org/W1862292403 |
| cited_by_count | 15 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 10 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 5 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fphar.2024.1381168 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S132108250 |
| best_oa_location.source.issn | 1663-9812 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1663-9812 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Pharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Pharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fphar.2024.1381168 |
| primary_location.id | doi:10.3389/fphar.2024.1381168 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S132108250 |
| primary_location.source.issn | 1663-9812 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1663-9812 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Pharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Pharmacology |
| primary_location.landing_page_url | https://doi.org/10.3389/fphar.2024.1381168 |
| publication_date | 2024-04-24 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4210250807, https://openalex.org/W2293585960, https://openalex.org/W2117021545, https://openalex.org/W2018724286, https://openalex.org/W2140477106, https://openalex.org/W2887443702, https://openalex.org/W2953282545, https://openalex.org/W4223940386, https://openalex.org/W3199647353, https://openalex.org/W2600452401, https://openalex.org/W2403874820, https://openalex.org/W2094431022, https://openalex.org/W2031724786, https://openalex.org/W1999478182, https://openalex.org/W2068633908, https://openalex.org/W2042377388, https://openalex.org/W2009060922, https://openalex.org/W1967018540, https://openalex.org/W2064609355, https://openalex.org/W4214720244, https://openalex.org/W2101139969, https://openalex.org/W1979210434, https://openalex.org/W2132056063, https://openalex.org/W2082959814, https://openalex.org/W2033383891, https://openalex.org/W4319263088, https://openalex.org/W3006770125, https://openalex.org/W2027399998, https://openalex.org/W2626141602, https://openalex.org/W2095682420, https://openalex.org/W2165556149, https://openalex.org/W2015047966, https://openalex.org/W2412578066, https://openalex.org/W3194235344, https://openalex.org/W2269239459, https://openalex.org/W2724336500, https://openalex.org/W2029484950, https://openalex.org/W2029197798, https://openalex.org/W2070777085, https://openalex.org/W2096550742, https://openalex.org/W2157287007, https://openalex.org/W2009940298, https://openalex.org/W2521317541, https://openalex.org/W2620055784, https://openalex.org/W3012283572, https://openalex.org/W1979273476, https://openalex.org/W2801540524, https://openalex.org/W2031954417, https://openalex.org/W2194714667, https://openalex.org/W2991855137, https://openalex.org/W34668368, https://openalex.org/W2941293438, https://openalex.org/W1975692560, https://openalex.org/W1970602002, https://openalex.org/W2009858080, https://openalex.org/W2031087599, https://openalex.org/W3048717461, https://openalex.org/W2900631254, https://openalex.org/W2952410122, https://openalex.org/W2752462373, https://openalex.org/W2964157488, https://openalex.org/W2963076068, https://openalex.org/W1983315005, https://openalex.org/W2128609874, https://openalex.org/W49845552, https://openalex.org/W1627803359, https://openalex.org/W2168473428, https://openalex.org/W2797292560, https://openalex.org/W4294845024, https://openalex.org/W2046569321, https://openalex.org/W2892844483, https://openalex.org/W206344101, https://openalex.org/W2141410747, https://openalex.org/W3113720224, https://openalex.org/W4389093474, https://openalex.org/W2159104864, https://openalex.org/W2081279521, https://openalex.org/W6606344941, https://openalex.org/W2800289222, https://openalex.org/W2144889160, https://openalex.org/W3135698669, https://openalex.org/W2096083625, https://openalex.org/W3180020611, https://openalex.org/W3033448659, https://openalex.org/W2216033157, https://openalex.org/W4365150263, https://openalex.org/W2111099379, https://openalex.org/W4309447702, https://openalex.org/W2029746613, https://openalex.org/W4281616222, https://openalex.org/W3032920186, https://openalex.org/W1573937463, https://openalex.org/W2623081970, https://openalex.org/W2093476365, https://openalex.org/W2619406637, https://openalex.org/W2052355595, https://openalex.org/W2810158754, https://openalex.org/W2980652798, https://openalex.org/W3020424172, https://openalex.org/W3110971778, https://openalex.org/W2102169774, https://openalex.org/W2123081347, https://openalex.org/W1988185604, https://openalex.org/W4281298149, https://openalex.org/W3189291204, https://openalex.org/W2900090807, https://openalex.org/W3005444396, https://openalex.org/W3112627922, https://openalex.org/W3089191828, https://openalex.org/W2037979281, https://openalex.org/W154704142, https://openalex.org/W2171665032, https://openalex.org/W2407406252, https://openalex.org/W1984879354, https://openalex.org/W3147073996, https://openalex.org/W1990174038, https://openalex.org/W3168958685, https://openalex.org/W2944627685, https://openalex.org/W2031642491, https://openalex.org/W3106143834, https://openalex.org/W2109716912, https://openalex.org/W1967729496, https://openalex.org/W2252060117, https://openalex.org/W3156231141, https://openalex.org/W4386289604, https://openalex.org/W2156517973, https://openalex.org/W3136850445, https://openalex.org/W2480045008, https://openalex.org/W3091558907, https://openalex.org/W4224220281, https://openalex.org/W2029033394, https://openalex.org/W1990178004, https://openalex.org/W2017515560, https://openalex.org/W2086524378, https://openalex.org/W3194407496, https://openalex.org/W4376279000, https://openalex.org/W2096367061, https://openalex.org/W2166961829, https://openalex.org/W2060817283, https://openalex.org/W2113056756, https://openalex.org/W1970260075, https://openalex.org/W2100543217, https://openalex.org/W2803961606, https://openalex.org/W2096501714, https://openalex.org/W2126199679, https://openalex.org/W2149816812, https://openalex.org/W2795208162, https://openalex.org/W1968637358, https://openalex.org/W4388617035, https://openalex.org/W4281721695, https://openalex.org/W1964963969, https://openalex.org/W1825572943, https://openalex.org/W4283010842, https://openalex.org/W4307658752, https://openalex.org/W1985845937, https://openalex.org/W2022140142, https://openalex.org/W4321166409, https://openalex.org/W3121466164, https://openalex.org/W2402892277, https://openalex.org/W2101259235, https://openalex.org/W2022093187, https://openalex.org/W3099265409, https://openalex.org/W1996676239, https://openalex.org/W2061875333, https://openalex.org/W4377011375, https://openalex.org/W3121457407, https://openalex.org/W3094762267, https://openalex.org/W4389131063, https://openalex.org/W2989630699, https://openalex.org/W2133459589, https://openalex.org/W4214854118, https://openalex.org/W2738118286, https://openalex.org/W2105042940 |
| referenced_works_count | 173 |
| abstract_inverted_index.a | 14, 40, 127, 176, 187, 193, 210 |
| abstract_inverted_index.as | 47, 155 |
| abstract_inverted_index.by | 3, 24, 75 |
| abstract_inverted_index.in | 5, 17, 106, 130, 144, 179 |
| abstract_inverted_index.of | 22, 39, 43, 81, 94, 124, 136, 158, 167, 196, 223 |
| abstract_inverted_index.to | 36, 67, 71, 100, 191, 204, 226 |
| abstract_inverted_index.DNA | 11, 63 |
| abstract_inverted_index.aim | 66 |
| abstract_inverted_index.and | 20, 29, 62, 86, 119, 140, 162, 170, 215 |
| abstract_inverted_index.are | 89 |
| abstract_inverted_index.has | 34, 148 |
| abstract_inverted_index.led | 35 |
| abstract_inverted_index.may | 114 |
| abstract_inverted_index.the | 10, 18, 37, 78, 92, 122, 134, 159, 165, 219 |
| abstract_inverted_index.Such | 111 |
| abstract_inverted_index.This | 32, 207 |
| abstract_inverted_index.been | 149 |
| abstract_inverted_index.curb | 72 |
| abstract_inverted_index.drug | 125, 146 |
| abstract_inverted_index.gene | 6, 27, 69 |
| abstract_inverted_index.more | 115, 188, 213 |
| abstract_inverted_index.play | 13 |
| abstract_inverted_index.role | 16, 154 |
| abstract_inverted_index.side | 201 |
| abstract_inverted_index.step | 211 |
| abstract_inverted_index.that | 185 |
| abstract_inverted_index.used | 105 |
| abstract_inverted_index.when | 104 |
| abstract_inverted_index.wide | 194 |
| abstract_inverted_index.with | 108, 199 |
| abstract_inverted_index.These | 50 |
| abstract_inverted_index.class | 42 |
| abstract_inverted_index.drugs | 174 |
| abstract_inverted_index.fewer | 200 |
| abstract_inverted_index.known | 46 |
| abstract_inverted_index.marks | 209 |
| abstract_inverted_index.novel | 41 |
| abstract_inverted_index.other | 109 |
| abstract_inverted_index.shift | 178 |
| abstract_inverted_index.their | 98, 153 |
| abstract_inverted_index.these | 95 |
| abstract_inverted_index.cancer | 23, 73, 82, 118, 131, 180 |
| abstract_inverted_index.cells. | 83 |
| abstract_inverted_index.drugs, | 51, 96 |
| abstract_inverted_index.drugs. | 49 |
| abstract_inverted_index.growth | 74 |
| abstract_inverted_index.hurdle | 129 |
| abstract_inverted_index.rhythm | 142 |
| abstract_inverted_index.target | 117 |
| abstract_inverted_index.trials | 88 |
| abstract_inverted_index.tumors | 225 |
| abstract_inverted_index.unique | 220 |
| abstract_inverted_index.Ongoing | 84 |
| abstract_inverted_index.ability | 99 |
| abstract_inverted_index.agents, | 45 |
| abstract_inverted_index.changes | 4 |
| abstract_inverted_index.crucial | 15 |
| abstract_inverted_index.effects | 202 |
| abstract_inverted_index.histone | 53, 56, 59 |
| abstract_inverted_index.improve | 101 |
| abstract_inverted_index.insight | 33 |
| abstract_inverted_index.patient | 171 |
| abstract_inverted_index.precise | 189, 216 |
| abstract_inverted_index.promise | 186 |
| abstract_inverted_index.thereby | 163 |
| abstract_inverted_index.towards | 212 |
| abstract_inverted_index.tumors, | 197 |
| abstract_inverted_index.without | 8 |
| abstract_inverted_index.activity | 28 |
| abstract_inverted_index.altering | 9, 77 |
| abstract_inverted_index.approach | 190 |
| abstract_inverted_index.cellular | 30 |
| abstract_inverted_index.clinical | 87 |
| abstract_inverted_index.compared | 203 |
| abstract_inverted_index.control, | 139 |
| abstract_inverted_index.critical | 156 |
| abstract_inverted_index.efficacy | 93 |
| abstract_inverted_index.modulate | 68 |
| abstract_inverted_index.offering | 182 |
| abstract_inverted_index.optimize | 227 |
| abstract_inverted_index.outcomes | 103 |
| abstract_inverted_index.overcome | 121 |
| abstract_inverted_index.paradigm | 177 |
| abstract_inverted_index.profiles | 222 |
| abstract_inverted_index.progress | 208 |
| abstract_inverted_index.research | 85 |
| abstract_inverted_index.spectrum | 195 |
| abstract_inverted_index.targeted | 183 |
| abstract_inverted_index.therapy. | 132 |
| abstract_inverted_index.treating | 192 |
| abstract_inverted_index.uniquely | 76 |
| abstract_inverted_index.challenge | 123 |
| abstract_inverted_index.circadian | 141 |
| abstract_inverted_index.function. | 31 |
| abstract_inverted_index.including | 52 |
| abstract_inverted_index.landscape | 80, 161 |
| abstract_inverted_index.modifiers | 157 |
| abstract_inverted_index.outcomes. | 172 |
| abstract_inverted_index.represent | 175 |
| abstract_inverted_index.responses | 147 |
| abstract_inverted_index.sequence, | 12 |
| abstract_inverted_index.therapies | 113, 184 |
| abstract_inverted_index.treatment | 228 |
| abstract_inverted_index.Epigenetic | 0, 173 |
| abstract_inverted_index.epigenetic | 48, 79, 160, 221 |
| abstract_inverted_index.evaluating | 91 |
| abstract_inverted_index.expression | 7, 70 |
| abstract_inverted_index.importance | 135 |
| abstract_inverted_index.individual | 224 |
| abstract_inverted_index.leveraging | 218 |
| abstract_inverted_index.modulating | 145 |
| abstract_inverted_index.nutrition, | 137 |
| abstract_inverted_index.regulation | 143 |
| abstract_inverted_index.rigorously | 90 |
| abstract_inverted_index.treatment, | 181 |
| abstract_inverted_index.combination | 107, 112 |
| abstract_inverted_index.deacetylase | 54 |
| abstract_inverted_index.development | 19, 38 |
| abstract_inverted_index.effectively | 116 |
| abstract_inverted_index.influencing | 26, 164 |
| abstract_inverted_index.inhibitors, | 55, 58, 61, 65 |
| abstract_inverted_index.potentially | 120, 198 |
| abstract_inverted_index.progression | 21 |
| abstract_inverted_index.recognized, | 151 |
| abstract_inverted_index.resistance, | 126 |
| abstract_inverted_index.significant | 128 |
| abstract_inverted_index.strategies. | 229 |
| abstract_inverted_index.therapeutic | 44, 102 |
| abstract_inverted_index.traditional | 205 |
| abstract_inverted_index.treatments. | 110 |
| abstract_inverted_index.highlighting | 152 |
| abstract_inverted_index.increasingly | 150 |
| abstract_inverted_index.inflammation | 138 |
| abstract_inverted_index.particularly | 97 |
| abstract_inverted_index.personalized | 214 |
| abstract_inverted_index.Additionally, | 133 |
| abstract_inverted_index.characterized | 2 |
| abstract_inverted_index.chemotherapy. | 206 |
| abstract_inverted_index.effectiveness | 166 |
| abstract_inverted_index.interventions | 169 |
| abstract_inverted_index.significantly | 25 |
| abstract_inverted_index.interventions, | 217 |
| abstract_inverted_index.modifications, | 1 |
| abstract_inverted_index.pharmacological | 168 |
| abstract_inverted_index.acetyltransferase | 57 |
| abstract_inverted_index.methyltransferase | 60, 64 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9572396 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |