The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective Article Swipe

PDF

Maria Clara Costa Calvo , Heliana Parra , Raquel Santeliz , Jordan Bautista , Eliana Luzardo , Nelson Villasmil , Maria Sofía Martinez , M.F. Lander Chacin , Clímaco Cano , Ana Checa-Ros , Luis D’Marco , Valmore Bermúdez , Juan Bautista De Sanctis ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.17925/ee.2024.20.1.5

During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose to the foetus. These metabolic modifications develop what is known as physiological insulin resistance. When this process is altered, however, gestational diabetes mellitus (GDM) occurs. GDM is a multifactorial disease, and genetic and environmental factors play a crucial role in its aetiopathogenesis. GDM has been linked to both macroscopic and molecular alterations in placental tissues that affect placental physiology. This review summarizes the role of the placenta in the development of GDM from a molecular perspective, including hormonal and pro-inflammatory changes. Inflammation and hormonal imbalance, the characteristics dominating the GDM microenvironment, are responsible for placental changes in size and vascularity, leading to dysregulation in maternal and foetal circulations and to complications in the newborn. In conclusion, since the hormonal mechanisms operating in GDM have not been fully elucidated, more research should be done to improve the quality of life of patients with GDM and their future children.

Related Topics

Gestational Diabetes

Perspective (Graphical)

Artificial Intelligence

Concepts

Gestational diabetes Perspective (graphical) Diabetes mellitus Medicine Obstetrics Placenta Endocrinology Pregnancy Gestation Biology Fetus Genetics Computer science Artificial intelligence

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.17925/ee.2024.20.1.5
PDF: https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf
OA Status: bronze
Cited By: 27
References: 120
Related Works: 10
OpenAlex ID: https://openalex.org/W4397006739

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4397006739

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.17925/ee.2024.20.1.5

Digital Object Identifier
Title: The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2024

Year of publication
Publication date: 2024-01-01

Full publication date if available
Authors: Maria Clara Costa Calvo, Heliana Parra, Raquel Santeliz, Jordan Bautista, Eliana Luzardo, Nelson Villasmil, Maria Sofía Martinez, M.F. Lander Chacin, Clímaco Cano, Ana Checa-Ros, Luis D’Marco, Valmore Bermúdez, Juan Bautista De Sanctis

List of authors in order
Landing page: https://doi.org/10.17925/ee.2024.20.1.5

Publisher landing page
PDF URL: https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: bronze

Open access status per OpenAlex
OA URL: https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf

Direct OA link when available
Concepts: Gestational diabetes, Perspective (graphical), Diabetes mellitus, Medicine, Obstetrics, Placenta, Endocrinology, Pregnancy, Gestation, Biology, Fetus, Genetics, Computer science, Artificial intelligence

Top concepts (fields/topics) attached by OpenAlex
Cited by: 27

Total citation count in OpenAlex
Citations by year (recent): 2025: 20, 2024: 7

Per-year citation counts (last 5 years)
References (count): 120

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4397006739
doi	https://doi.org/10.17925/ee.2024.20.1.5
ids.doi	https://doi.org/10.17925/ee.2024.20.1.5
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/38812661
ids.openalex	https://openalex.org/W4397006739
fwci	38.81452338
type	article
title	The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective
biblio.issue	1
biblio.volume	20
biblio.last_page	18
biblio.first_page	10
topics[0].id	https://openalex.org/T10673
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2729
topics[0].subfield.display_name	Obstetrics and Gynecology
topics[0].display_name	Gestational Diabetes Research and Management
topics[1].id	https://openalex.org/T10290
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9998999834060669
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2729
topics[1].subfield.display_name	Obstetrics and Gynecology
topics[1].display_name	Pregnancy and preeclampsia studies
topics[2].id	https://openalex.org/T11629
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9973000288009644
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2735
topics[2].subfield.display_name	Pediatrics, Perinatology and Child Health
topics[2].display_name	Birth, Development, and Health
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2779434492
concepts[0].level	4
concepts[0].score	0.8510048389434814
concepts[0].wikidata	https://www.wikidata.org/wiki/Q126691
concepts[0].display_name	Gestational diabetes
concepts[1].id	https://openalex.org/C12713177
concepts[1].level	2
concepts[1].score	0.7111220359802246
concepts[1].wikidata	https://www.wikidata.org/wiki/Q1900281
concepts[1].display_name	Perspective (graphical)
concepts[2].id	https://openalex.org/C555293320
concepts[2].level	2
concepts[2].score	0.5408698916435242
concepts[2].wikidata	https://www.wikidata.org/wiki/Q12206
concepts[2].display_name	Diabetes mellitus
concepts[3].id	https://openalex.org/C71924100
concepts[3].level	0
concepts[3].score	0.5149737000465393
concepts[3].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[3].display_name	Medicine
concepts[4].id	https://openalex.org/C131872663
concepts[4].level	1
concepts[4].score	0.44486668705940247
concepts[4].wikidata	https://www.wikidata.org/wiki/Q5284418
concepts[4].display_name	Obstetrics
concepts[5].id	https://openalex.org/C2776953305
concepts[5].level	4
concepts[5].score	0.42727208137512207
concepts[5].wikidata	https://www.wikidata.org/wiki/Q1212935
concepts[5].display_name	Placenta
concepts[6].id	https://openalex.org/C134018914
concepts[6].level	1
concepts[6].score	0.3406711220741272
concepts[6].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[6].display_name	Endocrinology
concepts[7].id	https://openalex.org/C2779234561
concepts[7].level	2
concepts[7].score	0.3284987509250641
concepts[7].wikidata	https://www.wikidata.org/wiki/Q11995
concepts[7].display_name	Pregnancy
concepts[8].id	https://openalex.org/C46973012
concepts[8].level	3
concepts[8].score	0.3055244982242584
concepts[8].wikidata	https://www.wikidata.org/wiki/Q28627
concepts[8].display_name	Gestation
concepts[9].id	https://openalex.org/C86803240
concepts[9].level	0
concepts[9].score	0.18500036001205444
concepts[9].wikidata	https://www.wikidata.org/wiki/Q420
concepts[9].display_name	Biology
concepts[10].id	https://openalex.org/C172680121
concepts[10].level	3
concepts[10].score	0.17505303025245667
concepts[10].wikidata	https://www.wikidata.org/wiki/Q26513
concepts[10].display_name	Fetus
concepts[11].id	https://openalex.org/C54355233
concepts[11].level	1
concepts[11].score	0.09520429372787476
concepts[11].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[11].display_name	Genetics
concepts[12].id	https://openalex.org/C41008148
concepts[12].level	0
concepts[12].score	0.08310028910636902
concepts[12].wikidata	https://www.wikidata.org/wiki/Q21198
concepts[12].display_name	Computer science
concepts[13].id	https://openalex.org/C154945302
concepts[13].level	1
concepts[13].score	0.0
concepts[13].wikidata	https://www.wikidata.org/wiki/Q11660
concepts[13].display_name	Artificial intelligence
keywords[0].id	https://openalex.org/keywords/gestational-diabetes
keywords[0].score	0.8510048389434814
keywords[0].display_name	Gestational diabetes
keywords[1].id	https://openalex.org/keywords/perspective
keywords[1].score	0.7111220359802246
keywords[1].display_name	Perspective (graphical)
keywords[2].id	https://openalex.org/keywords/diabetes-mellitus
keywords[2].score	0.5408698916435242
keywords[2].display_name	Diabetes mellitus
keywords[3].id	https://openalex.org/keywords/medicine
keywords[3].score	0.5149737000465393
keywords[3].display_name	Medicine
keywords[4].id	https://openalex.org/keywords/obstetrics
keywords[4].score	0.44486668705940247
keywords[4].display_name	Obstetrics
keywords[5].id	https://openalex.org/keywords/placenta
keywords[5].score	0.42727208137512207
keywords[5].display_name	Placenta
keywords[6].id	https://openalex.org/keywords/endocrinology
keywords[6].score	0.3406711220741272
keywords[6].display_name	Endocrinology
keywords[7].id	https://openalex.org/keywords/pregnancy
keywords[7].score	0.3284987509250641
keywords[7].display_name	Pregnancy
keywords[8].id	https://openalex.org/keywords/gestation
keywords[8].score	0.3055244982242584
keywords[8].display_name	Gestation
keywords[9].id	https://openalex.org/keywords/biology
keywords[9].score	0.18500036001205444
keywords[9].display_name	Biology
keywords[10].id	https://openalex.org/keywords/fetus
keywords[10].score	0.17505303025245667
keywords[10].display_name	Fetus
keywords[11].id	https://openalex.org/keywords/genetics
keywords[11].score	0.09520429372787476
keywords[11].display_name	Genetics
keywords[12].id	https://openalex.org/keywords/computer-science
keywords[12].score	0.08310028910636902
keywords[12].display_name	Computer science
language	en
locations[0].id	doi:10.17925/ee.2024.20.1.5
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4387281839
locations[0].source.issn	2752-5457
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	2752-5457
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	touchREVIEWS in Endocrinology
locations[0].source.host_organization
locations[0].source.host_organization_name
locations[0].source.host_organization_lineage
locations[0].license
locations[0].pdf_url	https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	touchREVIEWS in Endocrinology
locations[0].landing_page_url	https://doi.org/10.17925/ee.2024.20.1.5
locations[1].id	pmid:38812661
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	TouchREVIEWS in endocrinology
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/38812661
locations[2].id	pmh:oai:pubmedcentral.nih.gov:11132656
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license	cc-by
locations[2].pdf_url
locations[2].version	publishedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/cc-by
locations[2].is_accepted	True
locations[2].is_published	True
locations[2].raw_source_name	touchREV Endocrinol
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/11132656
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5032390176
authorships[0].author.orcid	https://orcid.org/0000-0002-9569-2796
authorships[0].author.display_name	Maria Clara Costa Calvo
authorships[0].countries	VE
authorships[0].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[0].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[0].institutions[0].id	https://openalex.org/I1648549
authorships[0].institutions[0].ror	https://ror.org/04vy5s568
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I1648549
authorships[0].institutions[0].country_code	VE
authorships[0].institutions[0].display_name	University of Zulia
authorships[0].author_position	first
authorships[0].raw_author_name	María José Calvo
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[1].author.id	https://openalex.org/A5049393567
authorships[1].author.orcid	https://orcid.org/0000-0002-6604-4212
authorships[1].author.display_name	Heliana Parra
authorships[1].countries	VE
authorships[1].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[1].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[1].institutions[0].id	https://openalex.org/I1648549
authorships[1].institutions[0].ror	https://ror.org/04vy5s568
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I1648549
authorships[1].institutions[0].country_code	VE
authorships[1].institutions[0].display_name	University of Zulia
authorships[1].author_position	middle
authorships[1].raw_author_name	Heliana Parra
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[2].author.id	https://openalex.org/A5071369454
authorships[2].author.orcid	https://orcid.org/0000-0003-0761-5879
authorships[2].author.display_name	Raquel Santeliz
authorships[2].countries	VE
authorships[2].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[2].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[2].institutions[0].id	https://openalex.org/I1648549
authorships[2].institutions[0].ror	https://ror.org/04vy5s568
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I1648549
authorships[2].institutions[0].country_code	VE
authorships[2].institutions[0].display_name	University of Zulia
authorships[2].author_position	middle
authorships[2].raw_author_name	Raquel Santeliz
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[3].author.id	https://openalex.org/A5056030969
authorships[3].author.orcid	https://orcid.org/0000-0003-4059-7086
authorships[3].author.display_name	Jordan Bautista
authorships[3].countries	VE
authorships[3].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[3].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[3].institutions[0].id	https://openalex.org/I1648549
authorships[3].institutions[0].ror	https://ror.org/04vy5s568
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I1648549
authorships[3].institutions[0].country_code	VE
authorships[3].institutions[0].display_name	University of Zulia
authorships[3].author_position	middle
authorships[3].raw_author_name	Jordan Bautista
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[4].author.id	https://openalex.org/A5004540678
authorships[4].author.orcid	https://orcid.org/0000-0002-5639-7639
authorships[4].author.display_name	Eliana Luzardo
authorships[4].countries	VE
authorships[4].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[4].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[4].institutions[0].id	https://openalex.org/I1648549
authorships[4].institutions[0].ror	https://ror.org/04vy5s568
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I1648549
authorships[4].institutions[0].country_code	VE
authorships[4].institutions[0].display_name	University of Zulia
authorships[4].author_position	middle
authorships[4].raw_author_name	Eliana Luzardo
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[5].author.id	https://openalex.org/A5072322878
authorships[5].author.orcid	https://orcid.org/0000-0002-7227-4866
authorships[5].author.display_name	Nelson Villasmil
authorships[5].countries	VE
authorships[5].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[5].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[5].institutions[0].id	https://openalex.org/I1648549
authorships[5].institutions[0].ror	https://ror.org/04vy5s568
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I1648549
authorships[5].institutions[0].country_code	VE
authorships[5].institutions[0].display_name	University of Zulia
authorships[5].author_position	middle
authorships[5].raw_author_name	Nelson Villasmil
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[6].author.id	https://openalex.org/A5064776868
authorships[6].author.orcid	https://orcid.org/0000-0002-3419-0960
authorships[6].author.display_name	Maria Sofía Martinez
authorships[6].countries	VE
authorships[6].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[6].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[6].institutions[0].id	https://openalex.org/I1648549
authorships[6].institutions[0].ror	https://ror.org/04vy5s568
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I1648549
authorships[6].institutions[0].country_code	VE
authorships[6].institutions[0].display_name	University of Zulia
authorships[6].author_position	middle
authorships[6].raw_author_name	María Sofía Martínez
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[7].author.id	https://openalex.org/A5103566781
authorships[7].author.orcid
authorships[7].author.display_name	M.F. Lander Chacin
authorships[7].countries	CO
authorships[7].affiliations[0].institution_ids	https://openalex.org/I4210132036
authorships[7].affiliations[0].raw_affiliation_string	. Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia;
authorships[7].institutions[0].id	https://openalex.org/I4210132036
authorships[7].institutions[0].ror	https://ror.org/02njbw696
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I4210132036
authorships[7].institutions[0].country_code	CO
authorships[7].institutions[0].display_name	Universidad Simón Bolívar
authorships[7].author_position	middle
authorships[7].raw_author_name	Maricamen Chacín
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	. Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia;
authorships[8].author.id	https://openalex.org/A5113122437
authorships[8].author.orcid
authorships[8].author.display_name	Clímaco Cano
authorships[8].countries	VE
authorships[8].affiliations[0].institution_ids	https://openalex.org/I1648549
authorships[8].affiliations[0].raw_affiliation_string	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[8].institutions[0].id	https://openalex.org/I1648549
authorships[8].institutions[0].ror	https://ror.org/04vy5s568
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I1648549
authorships[8].institutions[0].country_code	VE
authorships[8].institutions[0].display_name	University of Zulia
authorships[8].author_position	middle
authorships[8].raw_author_name	Clímaco Cano
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela;
authorships[9].author.id	https://openalex.org/A5059590738
authorships[9].author.orcid	https://orcid.org/0000-0001-8958-6711
authorships[9].author.display_name	Ana Checa-Ros
authorships[9].countries	ES, GB
authorships[9].affiliations[0].institution_ids	https://openalex.org/I2800982320
authorships[9].affiliations[0].raw_affiliation_string	. Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain;
authorships[9].affiliations[1].institution_ids	https://openalex.org/I169199633
authorships[9].affiliations[1].raw_affiliation_string	. School of Life and Health Sciences, Aston University, Birmingham, United Kingdom;
authorships[9].institutions[0].id	https://openalex.org/I2800982320
authorships[9].institutions[0].ror	https://ror.org/01tnh0829
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I2800982320, https://openalex.org/I2801318690
authorships[9].institutions[0].country_code	ES
authorships[9].institutions[0].display_name	Universidad Cardenal Herrera CEU
authorships[9].institutions[1].id	https://openalex.org/I169199633
authorships[9].institutions[1].ror	https://ror.org/05j0ve876
authorships[9].institutions[1].type	education
authorships[9].institutions[1].lineage	https://openalex.org/I169199633
authorships[9].institutions[1].country_code	GB
authorships[9].institutions[1].display_name	Aston University
authorships[9].author_position	middle
authorships[9].raw_author_name	Ana Checa-Ros
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	. Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain;, . School of Life and Health Sciences, Aston University, Birmingham, United Kingdom;
authorships[10].author.id	https://openalex.org/A5090919713
authorships[10].author.orcid	https://orcid.org/0000-0003-0148-891X
authorships[10].author.display_name	Luis D’Marco
authorships[10].countries	ES
authorships[10].affiliations[0].institution_ids	https://openalex.org/I2800982320
authorships[10].affiliations[0].raw_affiliation_string	. Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain;
authorships[10].institutions[0].id	https://openalex.org/I2800982320
authorships[10].institutions[0].ror	https://ror.org/01tnh0829
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I2800982320, https://openalex.org/I2801318690
authorships[10].institutions[0].country_code	ES
authorships[10].institutions[0].display_name	Universidad Cardenal Herrera CEU
authorships[10].author_position	middle
authorships[10].raw_author_name	Luis D'Marco
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	. Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain;
authorships[11].author.id	https://openalex.org/A5058933826
authorships[11].author.orcid	https://orcid.org/0000-0003-1880-8887
authorships[11].author.display_name	Valmore Bermúdez
authorships[11].countries	CO
authorships[11].affiliations[0].institution_ids	https://openalex.org/I4210132036
authorships[11].affiliations[0].raw_affiliation_string	. Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia;
authorships[11].institutions[0].id	https://openalex.org/I4210132036
authorships[11].institutions[0].ror	https://ror.org/02njbw696
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I4210132036
authorships[11].institutions[0].country_code	CO
authorships[11].institutions[0].display_name	Universidad Simón Bolívar
authorships[11].author_position	middle
authorships[11].raw_author_name	Valmore Bermúdez
authorships[11].is_corresponding	True
authorships[11].raw_affiliation_strings	. Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia;
authorships[12].author.id	https://openalex.org/A5065894125
authorships[12].author.orcid	https://orcid.org/0000-0002-5480-4608
authorships[12].author.display_name	Juan Bautista De Sanctis
authorships[12].countries	CZ
authorships[12].affiliations[0].institution_ids	https://openalex.org/I4210146721, https://openalex.org/I70703428
authorships[12].affiliations[0].raw_affiliation_string	. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
authorships[12].institutions[0].id	https://openalex.org/I4210146721
authorships[12].institutions[0].ror	https://ror.org/041e7q719
authorships[12].institutions[0].type	facility
authorships[12].institutions[0].lineage	https://openalex.org/I4210146721
authorships[12].institutions[0].country_code	CZ
authorships[12].institutions[0].display_name	Institute of Molecular and Translational Medicine
authorships[12].institutions[1].id	https://openalex.org/I70703428
authorships[12].institutions[1].ror	https://ror.org/04qxnmv42
authorships[12].institutions[1].type	education
authorships[12].institutions[1].lineage	https://openalex.org/I70703428
authorships[12].institutions[1].country_code	CZ
authorships[12].institutions[1].display_name	Palacký University Olomouc
authorships[12].author_position	last
authorships[12].raw_author_name	Juan Bautista De Sanctis
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
has_content.pdf	True
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf
open_access.oa_status	bronze
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T06:51:31.235846
primary_topic.id	https://openalex.org/T10673
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2729
primary_topic.subfield.display_name	Obstetrics and Gynecology
primary_topic.display_name	Gestational Diabetes Research and Management
related_works	https://openalex.org/W2371953778, https://openalex.org/W4321169775, https://openalex.org/W2391954612, https://openalex.org/W2471007198, https://openalex.org/W2186292959, https://openalex.org/W3126825686, https://openalex.org/W2013489575, https://openalex.org/W2615634422, https://openalex.org/W2418022250, https://openalex.org/W2411520407
cited_by_count	27
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	20
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	7
locations_count	3
best_oa_location.id	doi:10.17925/ee.2024.20.1.5
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4387281839
best_oa_location.source.issn	2752-5457
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	2752-5457
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	touchREVIEWS in Endocrinology
best_oa_location.source.host_organization
best_oa_location.source.host_organization_name
best_oa_location.source.host_organization_lineage
best_oa_location.license
best_oa_location.pdf_url	https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	touchREVIEWS in Endocrinology
best_oa_location.landing_page_url	https://doi.org/10.17925/ee.2024.20.1.5
primary_location.id	doi:10.17925/ee.2024.20.1.5
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4387281839
primary_location.source.issn	2752-5457
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	2752-5457
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	touchREVIEWS in Endocrinology
primary_location.source.host_organization
primary_location.source.host_organization_name
primary_location.source.host_organization_lineage
primary_location.license
primary_location.pdf_url	https://www.touchendocrinology.com/wp-content/uploads/sites/5/2024/03/5.-touchENDOCRINOLOGY_20.1_DMarco_10-18.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	touchREVIEWS in Endocrinology
primary_location.landing_page_url	https://doi.org/10.17925/ee.2024.20.1.5
publication_date	2024-01-01
publication_year	2024
referenced_works	https://openalex.org/W2418722043, https://openalex.org/W2406582234, https://openalex.org/W2413388679, https://openalex.org/W2135919607, https://openalex.org/W3174286082, https://openalex.org/W2034161006, https://openalex.org/W2105447851, https://openalex.org/W3210835704, https://openalex.org/W4311979502, https://openalex.org/W2899407606, https://openalex.org/W3108372566, https://openalex.org/W3133706516, https://openalex.org/W2084673631, https://openalex.org/W2115327724, https://openalex.org/W2180691807, https://openalex.org/W4226343892, https://openalex.org/W2994706529, https://openalex.org/W3122678989, https://openalex.org/W2149091090, https://openalex.org/W2045488762, https://openalex.org/W2783483626, https://openalex.org/W2312951505, https://openalex.org/W2621291871, https://openalex.org/W2559813849, https://openalex.org/W2169788983, https://openalex.org/W4224215735, https://openalex.org/W3173992796, https://openalex.org/W2164166774, https://openalex.org/W4225009162, https://openalex.org/W1992292699, https://openalex.org/W3146208376, https://openalex.org/W2127265323, https://openalex.org/W3017275198, https://openalex.org/W2792475502, https://openalex.org/W2616235706, https://openalex.org/W2083201780, https://openalex.org/W4281647858, https://openalex.org/W2090390027, https://openalex.org/W2892261498, https://openalex.org/W2048631942, https://openalex.org/W2953822763, https://openalex.org/W2920878613, https://openalex.org/W2128410589, https://openalex.org/W2741291215, https://openalex.org/W3161896610, https://openalex.org/W3134583789, https://openalex.org/W2029628194, https://openalex.org/W1525299471, https://openalex.org/W2939145125, https://openalex.org/W1485615546, https://openalex.org/W3035631882, https://openalex.org/W4205677347, https://openalex.org/W4233232608, https://openalex.org/W2899589207, https://openalex.org/W3201037039, https://openalex.org/W136899615, https://openalex.org/W2022691572, https://openalex.org/W2572405973, https://openalex.org/W2900236795, https://openalex.org/W1972530634, https://openalex.org/W4205324281, https://openalex.org/W2209584272, https://openalex.org/W2078193680, https://openalex.org/W2015634373, https://openalex.org/W4225156965, https://openalex.org/W3159631768, https://openalex.org/W2904999406, https://openalex.org/W2267456431, https://openalex.org/W4220907856, https://openalex.org/W2122546244, https://openalex.org/W4220893083, https://openalex.org/W4225276300, https://openalex.org/W3158945442, https://openalex.org/W2791856368, https://openalex.org/W3081394330, https://openalex.org/W4292337504, https://openalex.org/W2088011382, https://openalex.org/W2306103306, https://openalex.org/W2155538509, https://openalex.org/W2332074395, https://openalex.org/W1608151369, https://openalex.org/W3196613985, https://openalex.org/W2083360880, https://openalex.org/W2111953703, https://openalex.org/W2130500014, https://openalex.org/W2921485019, https://openalex.org/W2164974383, https://openalex.org/W2129160162, https://openalex.org/W2574654686, https://openalex.org/W2100028812, https://openalex.org/W2060530005, https://openalex.org/W2099051331, https://openalex.org/W2157695581, https://openalex.org/W2007714044, https://openalex.org/W2909529350, https://openalex.org/W2951464792, https://openalex.org/W4225326975, https://openalex.org/W3181566286, https://openalex.org/W2896312840, https://openalex.org/W2573721473, https://openalex.org/W1922663624, https://openalex.org/W3209978838, https://openalex.org/W1969858460, https://openalex.org/W2969997443, https://openalex.org/W3180676856, https://openalex.org/W2514797675, https://openalex.org/W2100179508, https://openalex.org/W2097367460, https://openalex.org/W2169580912, https://openalex.org/W2999795057, https://openalex.org/W2169849600, https://openalex.org/W2191173134, https://openalex.org/W1989816175, https://openalex.org/W2932425272, https://openalex.org/W2517376733, https://openalex.org/W3012344541, https://openalex.org/W2156371303, https://openalex.org/W2127937089, https://openalex.org/W3138940816, https://openalex.org/W3038244131
referenced_works_count	120
abstract_inverted_index.a	41, 50, 87
abstract_inverted_index.In	128
abstract_inverted_index.an	9
abstract_inverted_index.as	24
abstract_inverted_index.be	145
abstract_inverted_index.in	53, 66, 81, 110, 117, 125, 135
abstract_inverted_index.is	22, 31, 40
abstract_inverted_index.of	12, 78, 84, 151, 153
abstract_inverted_index.to	7, 14, 60, 115, 123, 147
abstract_inverted_index.GDM	39, 56, 85, 103, 136, 156
abstract_inverted_index.and	44, 46, 63, 92, 96, 112, 119, 122, 157
abstract_inverted_index.are	105
abstract_inverted_index.for	107
abstract_inverted_index.has	57
abstract_inverted_index.its	54
abstract_inverted_index.not	138
abstract_inverted_index.the	15, 76, 79, 82, 99, 102, 126, 131, 149
abstract_inverted_index.This	73
abstract_inverted_index.When	28
abstract_inverted_index.been	58, 139
abstract_inverted_index.both	61
abstract_inverted_index.done	146
abstract_inverted_index.from	86
abstract_inverted_index.have	137
abstract_inverted_index.life	152
abstract_inverted_index.more	142
abstract_inverted_index.play	49
abstract_inverted_index.role	52, 77
abstract_inverted_index.size	111
abstract_inverted_index.that	69
abstract_inverted_index.this	29
abstract_inverted_index.what	21
abstract_inverted_index.with	155
abstract_inverted_index.(GDM)	37
abstract_inverted_index.These	17
abstract_inverted_index.fully	140
abstract_inverted_index.known	23
abstract_inverted_index.since	130
abstract_inverted_index.their	158
abstract_inverted_index.women	2
abstract_inverted_index.During	0
abstract_inverted_index.affect	70
abstract_inverted_index.foetal	120
abstract_inverted_index.future	159
abstract_inverted_index.linked	59
abstract_inverted_index.review	74
abstract_inverted_index.should	144
abstract_inverted_index.supply	11
abstract_inverted_index.changes	6, 109
abstract_inverted_index.crucial	51
abstract_inverted_index.develop	20
abstract_inverted_index.factors	48
abstract_inverted_index.foetus.	16
abstract_inverted_index.genetic	45
abstract_inverted_index.glucose	13
abstract_inverted_index.improve	148
abstract_inverted_index.insulin	26
abstract_inverted_index.leading	114
abstract_inverted_index.occurs.	38
abstract_inverted_index.process	30
abstract_inverted_index.quality	150
abstract_inverted_index.several	4
abstract_inverted_index.tissues	68
abstract_inverted_index.undergo	3
abstract_inverted_index.adequate	10
abstract_inverted_index.altered,	32
abstract_inverted_index.changes.	94
abstract_inverted_index.diabetes	35
abstract_inverted_index.disease,	43
abstract_inverted_index.hormonal	91, 97, 132
abstract_inverted_index.however,	33
abstract_inverted_index.maternal	118
abstract_inverted_index.mellitus	36
abstract_inverted_index.newborn.	127
abstract_inverted_index.patients	154
abstract_inverted_index.placenta	80
abstract_inverted_index.research	143
abstract_inverted_index.children.	160
abstract_inverted_index.guarantee	8
abstract_inverted_index.including	90
abstract_inverted_index.metabolic	5, 18
abstract_inverted_index.molecular	64, 88
abstract_inverted_index.operating	134
abstract_inverted_index.placental	67, 71, 108
abstract_inverted_index.dominating	101
abstract_inverted_index.imbalance,	98
abstract_inverted_index.mechanisms	133
abstract_inverted_index.pregnancy,	1
abstract_inverted_index.summarizes	75
abstract_inverted_index.alterations	65
abstract_inverted_index.conclusion,	129
abstract_inverted_index.development	83
abstract_inverted_index.elucidated,	141
abstract_inverted_index.gestational	34
abstract_inverted_index.macroscopic	62
abstract_inverted_index.physiology.	72
abstract_inverted_index.resistance.	27
abstract_inverted_index.responsible	106
abstract_inverted_index.Inflammation	95
abstract_inverted_index.circulations	121
abstract_inverted_index.perspective,	89
abstract_inverted_index.vascularity,	113
abstract_inverted_index.complications	124
abstract_inverted_index.dysregulation	116
abstract_inverted_index.environmental	47
abstract_inverted_index.modifications	19
abstract_inverted_index.physiological	25
abstract_inverted_index.multifactorial	42
abstract_inverted_index.characteristics	100
abstract_inverted_index.pro-inflammatory	93
abstract_inverted_index.microenvironment,	104
abstract_inverted_index.aetiopathogenesis.	55
cited_by_percentile_year.max	100
cited_by_percentile_year.min	98
corresponding_author_ids	https://openalex.org/A5058933826
countries_distinct_count	5
institutions_distinct_count	13
corresponding_institution_ids	https://openalex.org/I4210132036
sustainable_development_goals[0].id	https://metadata.un.org/sdg/2
sustainable_development_goals[0].score	0.49000000953674316
sustainable_development_goals[0].display_name	Zero hunger
citation_normalized_percentile.value	0.9966136
citation_normalized_percentile.is_in_top_1_percent	True
citation_normalized_percentile.is_in_top_10_percent	True