The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1
Article Swipe
Julio Sainz de Aja
,
Sergio Menchero
,
Isabel Rollán
,
Antonio Barral
,
María Tiana
,
Wajid Jawaid
,
Itziar Cossío
,
Alba Álvarez
,
Gonzalo Carreño‐Tarragona
,
Claudio Badía-Careaga
,
Jennifer Nichols
,
Berthold Göttgens
,
Joan Isern
,
Miguel Manzanares
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15252/embj.201899122
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15252/embj.201899122
Progenitors of the first hematopoietic cells in the mouse arise in the early embryo from Brachyury-positive multipotent cells in the posterior-proximal region of the epiblast, but the mechanisms that specify primitive blood cells are still largely unknown. Pluripotency factors maintain uncommitted cells of the blastocyst and embryonic stem cells in the pluripotent state. However, little is known about the role played by these factors during later development, despite being expressed in the postimplantation epiblast. Using a dual transgene system for controlled expression at postimplantation stages, we found that Nanog blocks primitive hematopoiesis in the gastrulating embryo, resulting in a loss of red blood cells and downregulation of erythropoietic genes. Accordingly, Nanog-deficient embryonic stem cells are prone to erythropoietic differentiation. Moreover, Nanog expression in adults prevents the maturation of erythroid cells. By analysis of previous data for NANOG binding during stem cell differentiation and CRISPR/Cas9 genome editing, we found that Tal1 is a direct NANOG target. Our results show that Nanog regulates primitive hematopoiesis by directly repressing critical erythroid lineage specifiers.
Related Topics
Concepts
Homeobox protein NANOG
Biology
Epiblast
Nanog Homeobox Protein
Embryonic stem cell
Rex1
Cell biology
Brachyury
Stem cell
Haematopoiesis
SOX2
Induced pluripotent stem cell
Genetics
Embryo
Embryogenesis
Gastrulation
Mesoderm
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15252/embj.201899122
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201899122
- OA Status
- hybrid
- Cited By
- 5
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2915475047
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2915475047Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.15252/embj.201899122Digital Object Identifier
- Title
-
The pluripotency factor
NANOG controls primitive hematopoiesis and directly regulates Tal1Work title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-02-27Full publication date if available
- Authors
-
Julio Sainz de Aja, Sergio Menchero, Isabel Rollán, Antonio Barral, María Tiana, Wajid Jawaid, Itziar Cossío, Alba Álvarez, Gonzalo Carreño‐Tarragona, Claudio Badía-Careaga, Jennifer Nichols, Berthold Göttgens, Joan Isern, Miguel ManzanaresList of authors in order
- Landing page
-
https://doi.org/10.15252/embj.201899122Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201899122Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201899122Direct OA link when available
- Concepts
-
Homeobox protein NANOG, Biology, Epiblast, Nanog Homeobox Protein, Embryonic stem cell, Rex1, Cell biology, Brachyury, Stem cell, Haematopoiesis, SOX2, Induced pluripotent stem cell, Genetics, Embryo, Embryogenesis, Gastrulation, Mesoderm, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2022: 2, 2019: 2Per-year citation counts (last 5 years)
- References (count)
-
70Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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