The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets Article Swipe
Rosa Maria Vitale
,
Fabio Arturo Iannotti
,
Pietro Amodeo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22094876
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22094876
Cannabidiol (CBD), the major nonpsychoactive Cannabis constituent, has been proposed for the treatment of a wide panel of neurological and neuropsychiatric disorders, including anxiety, schizophrenia, epilepsy and drug addiction due to the ability of its versatile scaffold to interact with diverse molecular targets that are not restricted to the endocannabinoid system. Albeit the molecular mechanisms responsible for the therapeutic effects of CBD have yet to be fully elucidated, many efforts have been devoted in the last decades to shed light on its complex pharmacological profile. In particular, an ever-increasing number of molecular targets linked to those disorders have been identified for this phytocannabinoid, along with the modulatory effects of CBD on their cascade signaling. In this view, here we will try to provide a comprehensive and up-to-date overview of the molecular basis underlying the therapeutic effects of CBD involved in the treatment of neurological and neuropsychiatric disorders.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms22094876
- https://www.mdpi.com/1422-0067/22/9/4876/pdf?version=1620206240
- OA Status
- gold
- Cited By
- 66
- References
- 145
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W3158011779Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms22094876Digital Object Identifier
- Title
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The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and TargetsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-05-05Full publication date if available
- Authors
-
Rosa Maria Vitale, Fabio Arturo Iannotti, Pietro AmodeoList of authors in order
- Landing page
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https://doi.org/10.3390/ijms22094876Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/22/9/4876/pdf?version=1620206240Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/22/9/4876/pdf?version=1620206240Direct OA link when available
- Concepts
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Cannabidiol, Schizophrenia (object-oriented programming), Neuroscience, Medicine, Addiction, Epilepsy, Endocannabinoid system, Drug, Cannabis, Bioinformatics, Psychiatry, Pharmacology, Psychology, Biology, Receptor, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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66Total citation count in OpenAlex
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2025: 7, 2024: 19, 2023: 18, 2022: 15, 2021: 7Per-year citation counts (last 5 years)
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145Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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