The Psychiatric Genomics Consortium: Discoveries and Directions Article Swipe
Arpana Agrawal
,
Cynthia M. Bulik
,
Dawit Abebe
,
Ole A. Andreassen
,
Elizabeth G. Atkinson
,
Karmel W. Choi
,
Aiden Corvin
,
Helena L. Davies
,
Lea K. Davis
,
Anna R. Docherty
,
Howard J. Edenberg
,
Barbara Franke
,
Joel Gelernter
,
Paola Giusti‐Rodríguez
,
John M. Hettema
,
Jens Hjerling‐Leffler
,
Hailiang Huang
,
Emma C. Johnson
,
Cathryn M. Lewis
,
Mary-Ellen Lynall
,
Andrew M. McIntosh
,
Janitza L. Montalvo‐Ortiz
,
Niamh Mullins
,
Caroline M. Nievergelt
,
Kevin S. O’Connell
,
Michael O’Donovan
,
Adeniran Okewole
,
Roseann E. Peterson
,
Daniëlle Posthuma
,
Jonathan Sebat
,
Jordan W. Smoller
,
Reeteka Sud
,
Biju Viswanath
,
James C. Walters
,
Hyejung Won
,
Yi Lü
,
Patrick Sullivan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31234/osf.io/xykj2_v2
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31234/osf.io/xykj2_v2
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from the past half decade of research by this international group of investigators in five priority areas: discovery of common variants using GWAS; rare variation and its interplay with polygenic risk; leveraging genetics to go beyond diagnostic boundaries; ascribing functional attributes to genomic discoveries; and developing and implementing processes for data sharing, outreach to various communities, and training. The insights gained in these domains frame the agenda for the next phase of PGC research. In addition to accelerating integrative common and rare variant-, within- and across-disorder findings for multiple psychiatric and neurodevelopmental conditions, the next phase will leverage multiple populations to further elucidate genetic etiologies, integrate results with rapidly accumulating multi-modal functional genomics data to gain mechanistic understanding, bring genetic findings to clinically actionable phenotypes such as treatment response, and address the emerging use of polygenic scores. Taken together, these next steps will illuminate the biological underpinnings of psychiatric disorders, which continue to contribute to global morbidity and mortality.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.31234/osf.io/xykj2_v2
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407010991
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407010991Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31234/osf.io/xykj2_v2Digital Object Identifier
- Title
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The Psychiatric Genomics Consortium: Discoveries and DirectionsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-31Full publication date if available
- Authors
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Arpana Agrawal, Cynthia M. Bulik, Dawit Abebe, Ole A. Andreassen, Elizabeth G. Atkinson, Karmel W. Choi, Aiden Corvin, Helena L. Davies, Lea K. Davis, Anna R. Docherty, Howard J. Edenberg, Barbara Franke, Joel Gelernter, Paola Giusti‐Rodríguez, John M. Hettema, Jens Hjerling‐Leffler, Hailiang Huang, Emma C. Johnson, Cathryn M. Lewis, Mary-Ellen Lynall, Andrew M. McIntosh, Janitza L. Montalvo‐Ortiz, Niamh Mullins, Caroline M. Nievergelt, Kevin S. O’Connell, Michael O’Donovan, Adeniran Okewole, Roseann E. Peterson, Daniëlle Posthuma, Jonathan Sebat, Jordan W. Smoller, Reeteka Sud, Biju Viswanath, James C. Walters, Hyejung Won, Yi Lü, Patrick SullivanList of authors in order
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https://doi.org/10.31234/osf.io/xykj2_v2Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.31234/osf.io/xykj2_v2Direct OA link when available
- Concepts
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Genomics, Leverage (statistics), Psychiatric genetics, Biology, Psychiatry, Genetics, Medicine, Genome, Computer science, Schizophrenia (object-oriented programming), Gene, Artificial intelligenceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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