The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene Article Swipe
Jesse L. Berry
,
Ashley Polski
,
Webster K. Cavenee
,
Thaddeus P. Dryja
,
A. Linn Murphree
,
Brenda L. Gallie
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/genes10110879
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/genes10110879
The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have laid the foundation for numerous advances in the understanding of tumor suppressor genes, retinoblastoma tumorigenesis, and inheritance. Knowledge of RB1 led to a paradigm shift in the field of cancer genetics, including widespread acceptance of the concept of tumor suppressor genes, and has provided crucial diagnostic and prognostic information through genetic testing for patients affected by retinoblastoma. This article reviews the long history of RB1 gene research, characterization, and cloning, and also discusses recent advances in retinoblastoma genetics that have grown out of this foundational work.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/genes10110879
- https://www.mdpi.com/2073-4425/10/11/879/pdf?version=1572613004
- OA Status
- gold
- Cited By
- 66
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2985894798
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2985894798Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/genes10110879Digital Object Identifier
- Title
-
The RB1 Story: Characterization and Cloning of the First Tumor Suppressor GeneWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-01Full publication date if available
- Authors
-
Jesse L. Berry, Ashley Polski, Webster K. Cavenee, Thaddeus P. Dryja, A. Linn Murphree, Brenda L. GallieList of authors in order
- Landing page
-
https://doi.org/10.3390/genes10110879Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4425/10/11/879/pdf?version=1572613004Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4425/10/11/879/pdf?version=1572613004Direct OA link when available
- Concepts
-
Retinoblastoma, Genetics, Biology, Suppressor, Tumor suppressor gene, Gene, Carcinogenesis, Cloning (programming), Malignancy, Computational biology, Computer science, Programming languageTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
66Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 17, 2024: 16, 2023: 7, 2022: 8, 2021: 8Per-year citation counts (last 5 years)
- References (count)
-
68Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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