The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion Article Swipe
Tongyu Hu
,
Mingyu Pan
,
Yue Yin
,
Chen Wang
,
Ye Cui
,
Quanyi Wang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.790714
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.790714
Virus infection has been consistently threatening public health. The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. cGAS recognizes the pathogenic DNA in the cytosol and then synthesizes 2′3′-cyclic GMP-AMP (2′3′cGAMP). As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. However, viruses have evolved numerous strategies to hinder the cGAS-STING signal transduction, promoting their immune evasion. Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2021.790714
- OA Status
- gold
- Cited By
- 17
- References
- 140
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200089311
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4200089311Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2021.790714Digital Object Identifier
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The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral EvasionWork title
- Type
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reviewOpenAlex work type
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enPrimary language
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2021Year of publication
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2021-12-13Full publication date if available
- Authors
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Tongyu Hu, Mingyu Pan, Yue Yin, Chen Wang, Ye Cui, Quanyi WangList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2021.790714Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fmicb.2021.790714Direct OA link when available
- Concepts
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Evasion (ethics), Gene, Interferon, ATP synthase, Chemistry, Biology, Biochemistry, Cell biology, Virology, Immunology, Immune systemTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2025: 4, 2024: 4, 2023: 6, 2022: 3Per-year citation counts (last 5 years)
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140Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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