The relationship between parameters measured using intravoxel incoherent motion and dynamic contrast-enhanced MRI in patients with breast cancer undergoing neoadjuvant chemotherapy: a longitudinal cohort study Article Swipe
Zyad Almutlaq
,
Sarah E. Bacon
,
Daniel J. Wilson
,
Nisha Sharma
,
Tatendashe B Dondo
,
David L. Buckley
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1356173
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1356173
Purpose The primary aim of this study was to explore whether intravoxel incoherent motion (IVIM) can offer a contrast-agent-free alternative to dynamic contrast-enhanced (DCE)-MRI for measuring breast tumor perfusion. The secondary aim was to investigate the relationship between tissue diffusion measures from DWI and DCE-MRI measures of the tissue interstitial and extracellular volume fractions. Materials and methods A total of 108 paired DWI and DCE-MRI scans were acquired at 1.5 T from 40 patients with primary breast cancer (median age: 44.5 years) before and during neoadjuvant chemotherapy (NACT). DWI parameters included apparent diffusion coefficient (ADC), tissue diffusion (D t ), pseudo-diffusion coefficient (D p ), perfused fraction (f), and the product f×D p (microvascular blood flow). DCE-MRI parameters included blood flow (F b ), blood volume fraction (v b ), interstitial volume fraction (v e ) and extracellular volume fraction (v d ). All were extracted from three tumor regions of interest (whole-tumor, ADC cold-spot, and DCE-MRI hot-spot) at three MRI visits: pre-treatment, after one, and three cycles of NACT. Spearman’s rank correlation was used for assessing between-subject correlations (r), while repeated measures correlation was employed to assess within-subject correlations (r rm ) across visits between DWI and DCE-MRI parameters in each region. Results No statistically significant between-subject or within-subject correlation was found between the perfusion parameters estimated by IVIM and DCE-MRI (f versus v b and f×D p versus F b ; P=0.07–0.81). Significant moderate positive between-subject and within-subject correlations were observed between ADC and v e (r=0.461, r rm =0.597) and between D t and v e (r=0.405, r rm =0.514) as well as moderate positive within-subject correlations between ADC and v d and between D t and v d (r rm =0.619 and 0.564, respectively) in the whole-tumor region. Conclusion No correlations were observed between the perfusion parameters estimated by IVIM and DCE-MRI. This may be attributed to imprecise estimates of fxD p and v b , or an underlying difference in what IVIM and DCE-MRI measure. Care should be taken when interpreting the IVIM parameters (f and f×D p ) as surrogates for those measured using DCE-MRI. However, the moderate positive correlations found between ADC and D t and the DCE-MRI parameters v e and v d confirms the expectation that as the interstitial and extracellular volume fractions increase, water diffusion increases.
Related Topics
Concepts
Intravoxel incoherent motion
Medicine
Breast cancer
Nuclear medicine
Dynamic contrast-enhanced MRI
Perfusion
Breast MRI
Effective diffusion coefficient
Magnetic resonance imaging
Dynamic contrast
Rank correlation
Spearman's rank correlation coefficient
Correlation
Diffusion MRI
Radiology
Cancer
Internal medicine
Mammography
Mathematics
Geometry
Statistics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2024.1356173
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1356173/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398218572
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398218572Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2024.1356173Digital Object Identifier
- Title
-
The relationship between parameters measured using intravoxel incoherent motion and dynamic contrast-enhanced MRI in patients with breast cancer undergoing neoadjuvant chemotherapy: a longitudinal cohort studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-22Full publication date if available
- Authors
-
Zyad Almutlaq, Sarah E. Bacon, Daniel J. Wilson, Nisha Sharma, Tatendashe B Dondo, David L. BuckleyList of authors in order
- Landing page
-
https://doi.org/10.3389/fonc.2024.1356173Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1356173/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1356173/pdfDirect OA link when available
- Concepts
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Intravoxel incoherent motion, Medicine, Breast cancer, Nuclear medicine, Dynamic contrast-enhanced MRI, Perfusion, Breast MRI, Effective diffusion coefficient, Magnetic resonance imaging, Dynamic contrast, Rank correlation, Spearman's rank correlation coefficient, Correlation, Diffusion MRI, Radiology, Cancer, Internal medicine, Mammography, Mathematics, Geometry, StatisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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