The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions Article Swipe
Laurien De Roeck
,
Rob Colaes
,
Patrick Dupont
,
Stefan Sunaert
,
Steven De Vleeschouwer
,
Paul M. Clément
,
Charlotte Sleurs
,
Maarten Lambrecht
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdaf163
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdaf163
Background Emerging evidence suggests that cognitive dysfunction may result from damage to the brain’s functional network. This study explores the dose-dependent susceptibility of functional hubs to radiotherapy (RT) and associations with cognitive outcomes. Methods Attention, language, memory, motor, and executive functioning were assessed ≥1-year post-radiotherapy in 39 WHO grade 2 or 3 glioma patients with lesions predominantly located in the left frontal lobe and 50 matched healthy controls. Using resting-state functional imaging, weighted functional graphs were constructed for each participant, identifying hubs through graph measures. Linear regression models and Spearman’s rho correlations assessed associations between mean RT dose per region and cognitive domains. Results Higher RT doses to the left fusiform and inferior temporal gyri were linked to memory impairment (r(37) ≥ −0.565, PFDR ≤ 0.026), while poorer language outcomes were associated with higher doses to the left pars opercularis, rostral middle frontal gyrus, and caudate (r(37) ≥ −0.510, PFDR ≤ .040). Attention deficits were linked to higher doses to the left posterior cingulate, precentral, supramarginal, and postcentral gyrus ((37) ≥ −0.499, PFDR ≤ .040), with the left postcentral gyrus also associated with executive dysfunction (r(37) = −0.526, PFDR = .029). Significant correlations between RT dose and cognitive outcomes were more frequent in hubs than in non-hubs (50% vs. 12%, P = .005) and exclusively found in left-sided regions. Conclusions RT seems to adversely affect left-sided functional hubs in a dose-dependent manner in glioma patients, which may contribute to cognitive dysfunction. Protecting these regions from the dose may potentially mitigate cognitive side effects in glioma patients. However, since most lesions were located in the left hemisphere and baseline testing was unavailable, a potential effect of tumor location cannot be entirely ruled out.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/noajnl/vdaf163
- https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdf
- OA Status
- gold
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412507861
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412507861Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/noajnl/vdaf163Digital Object Identifier
- Title
-
The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-01Full publication date if available
- Authors
-
Laurien De Roeck, Rob Colaes, Patrick Dupont, Stefan Sunaert, Steven De Vleeschouwer, Paul M. Clément, Charlotte Sleurs, Maarten LambrechtList of authors in order
- Landing page
-
https://doi.org/10.1093/noajnl/vdaf163Publisher landing page
- PDF URL
-
https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdfDirect OA link when available
- Concepts
-
Frontal lobe, Glioma, Functional connectivity, Cognition, Medicine, Psychology, Neuroscience, Oncology, Internal medicine, Cancer researchTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4412507861 |
|---|---|
| doi | https://doi.org/10.1093/noajnl/vdaf163 |
| ids.doi | https://doi.org/10.1093/noajnl/vdaf163 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40842644 |
| ids.openalex | https://openalex.org/W4412507861 |
| fwci | 0.0 |
| type | article |
| title | The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions |
| biblio.issue | 1 |
| biblio.volume | 7 |
| biblio.last_page | vdaf163 |
| biblio.first_page | vdaf163 |
| topics[0].id | https://openalex.org/T13077 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9988999962806702 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Cancer-related cognitive impairment studies |
| topics[1].id | https://openalex.org/T10241 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9973000288009644 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2805 |
| topics[1].subfield.display_name | Cognitive Neuroscience |
| topics[1].display_name | Functional Brain Connectivity Studies |
| topics[2].id | https://openalex.org/T10129 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9936000108718872 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2716 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Glioma Diagnosis and Treatment |
| is_xpac | False |
| apc_list.value | 1622 |
| apc_list.currency | GBP |
| apc_list.value_usd | 1989 |
| apc_paid.value | 1622 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 1989 |
| concepts[0].id | https://openalex.org/C2777127467 |
| concepts[0].level | 2 |
| concepts[0].score | 0.715880811214447 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q749520 |
| concepts[0].display_name | Frontal lobe |
| concepts[1].id | https://openalex.org/C2778227246 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6163293719291687 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1365309 |
| concepts[1].display_name | Glioma |
| concepts[2].id | https://openalex.org/C3018011982 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5332844853401184 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7316120 |
| concepts[2].display_name | Functional connectivity |
| concepts[3].id | https://openalex.org/C169900460 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5302450656890869 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2200417 |
| concepts[3].display_name | Cognition |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.500361442565918 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C15744967 |
| concepts[5].level | 0 |
| concepts[5].score | 0.3996320366859436 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[5].display_name | Psychology |
| concepts[6].id | https://openalex.org/C169760540 |
| concepts[6].level | 1 |
| concepts[6].score | 0.38810357451438904 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[6].display_name | Neuroscience |
| concepts[7].id | https://openalex.org/C143998085 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3840053379535675 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[7].display_name | Oncology |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.36461341381073 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C502942594 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[9].display_name | Cancer research |
| keywords[0].id | https://openalex.org/keywords/frontal-lobe |
| keywords[0].score | 0.715880811214447 |
| keywords[0].display_name | Frontal lobe |
| keywords[1].id | https://openalex.org/keywords/glioma |
| keywords[1].score | 0.6163293719291687 |
| keywords[1].display_name | Glioma |
| keywords[2].id | https://openalex.org/keywords/functional-connectivity |
| keywords[2].score | 0.5332844853401184 |
| keywords[2].display_name | Functional connectivity |
| keywords[3].id | https://openalex.org/keywords/cognition |
| keywords[3].score | 0.5302450656890869 |
| keywords[3].display_name | Cognition |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.500361442565918 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/psychology |
| keywords[5].score | 0.3996320366859436 |
| keywords[5].display_name | Psychology |
| keywords[6].id | https://openalex.org/keywords/neuroscience |
| keywords[6].score | 0.38810357451438904 |
| keywords[6].display_name | Neuroscience |
| keywords[7].id | https://openalex.org/keywords/oncology |
| keywords[7].score | 0.3840053379535675 |
| keywords[7].display_name | Oncology |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.36461341381073 |
| keywords[8].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1093/noajnl/vdaf163 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210237914 |
| locations[0].source.issn | 2632-2498 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2632-2498 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Neuro-Oncology Advances |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Neuro-Oncology Advances |
| locations[0].landing_page_url | https://doi.org/10.1093/noajnl/vdaf163 |
| locations[1].id | pmid:40842644 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Neuro-oncology advances |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40842644 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12365900 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Neurooncol Adv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12365900 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5046449867 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2571-1816 |
| authorships[0].author.display_name | Laurien De Roeck |
| authorships[0].countries | BE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I99464096 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Radiation-Oncology, University Hospitals Leuven, Belgium |
| authorships[0].institutions[0].id | https://openalex.org/I99464096 |
| authorships[0].institutions[0].ror | https://ror.org/05f950310 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[0].institutions[0].country_code | BE |
| authorships[0].institutions[0].display_name | KU Leuven |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Laurien De Roeck |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Radiation-Oncology, University Hospitals Leuven, Belgium |
| authorships[1].author.id | https://openalex.org/A5115626797 |
| authorships[1].author.orcid | https://orcid.org/0009-0009-2553-415X |
| authorships[1].author.display_name | Rob Colaes |
| authorships[1].countries | BE, US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1314596251 |
| authorships[1].affiliations[0].raw_affiliation_string | Leuven Brain Institute , KU Leuven, |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210153928 |
| authorships[1].affiliations[1].raw_affiliation_string | Leuven Brain Institute, KU Leuven, Belgium |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I99464096 |
| authorships[1].affiliations[2].raw_affiliation_string | Department of Imaging & Pathology , KU Leuven |
| authorships[1].institutions[0].id | https://openalex.org/I99464096 |
| authorships[1].institutions[0].ror | https://ror.org/05f950310 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[1].institutions[0].country_code | BE |
| authorships[1].institutions[0].display_name | KU Leuven |
| authorships[1].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[1].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[1].institutions[1].country_code | BE |
| authorships[1].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[1].institutions[2].id | https://openalex.org/I1314596251 |
| authorships[1].institutions[2].ror | https://ror.org/00dcv1019 |
| authorships[1].institutions[2].type | facility |
| authorships[1].institutions[2].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[1].institutions[2].country_code | US |
| authorships[1].institutions[2].display_name | Allen Institute for Brain Science |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Rob Colaes |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Imaging & Pathology , KU Leuven, Leuven Brain Institute , KU Leuven,, Leuven Brain Institute, KU Leuven, Belgium |
| authorships[2].author.id | https://openalex.org/A5006794669 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1980-2540 |
| authorships[2].author.display_name | Patrick Dupont |
| authorships[2].countries | BE, US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210153928 |
| authorships[2].affiliations[0].raw_affiliation_string | Leuven Brain Institute, KU Leuven, Belgium |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I99464096 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Neurosciences, KU Leuven, Belgium |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I1314596251 |
| authorships[2].affiliations[2].raw_affiliation_string | Leuven Brain Institute , KU Leuven, |
| authorships[2].institutions[0].id | https://openalex.org/I99464096 |
| authorships[2].institutions[0].ror | https://ror.org/05f950310 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[2].institutions[0].country_code | BE |
| authorships[2].institutions[0].display_name | KU Leuven |
| authorships[2].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[2].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[2].institutions[1].country_code | BE |
| authorships[2].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[2].institutions[2].id | https://openalex.org/I1314596251 |
| authorships[2].institutions[2].ror | https://ror.org/00dcv1019 |
| authorships[2].institutions[2].type | facility |
| authorships[2].institutions[2].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[2].institutions[2].country_code | US |
| authorships[2].institutions[2].display_name | Allen Institute for Brain Science |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Patrick Dupont |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurosciences, KU Leuven, Belgium, Leuven Brain Institute , KU Leuven,, Leuven Brain Institute, KU Leuven, Belgium |
| authorships[3].author.id | https://openalex.org/A5000110993 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1177-4680 |
| authorships[3].author.display_name | Stefan Sunaert |
| authorships[3].countries | BE, US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I99464096 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Imaging & Pathology , KU Leuven |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210153928 |
| authorships[3].affiliations[1].raw_affiliation_string | Leuven Brain Institute, KU Leuven, Belgium |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I1314596251 |
| authorships[3].affiliations[2].raw_affiliation_string | Leuven Brain Institute , KU Leuven, |
| authorships[3].institutions[0].id | https://openalex.org/I99464096 |
| authorships[3].institutions[0].ror | https://ror.org/05f950310 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[3].institutions[0].country_code | BE |
| authorships[3].institutions[0].display_name | KU Leuven |
| authorships[3].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[3].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[3].institutions[1].country_code | BE |
| authorships[3].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[3].institutions[2].id | https://openalex.org/I1314596251 |
| authorships[3].institutions[2].ror | https://ror.org/00dcv1019 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[3].institutions[2].country_code | US |
| authorships[3].institutions[2].display_name | Allen Institute for Brain Science |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Stefan Sunaert |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Imaging & Pathology , KU Leuven, Leuven Brain Institute , KU Leuven,, Leuven Brain Institute, KU Leuven, Belgium |
| authorships[4].author.id | https://openalex.org/A5039346856 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-9576-9917 |
| authorships[4].author.display_name | Steven De Vleeschouwer |
| authorships[4].countries | BE, US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1314596251 |
| authorships[4].affiliations[0].raw_affiliation_string | Leuven Brain Institute , KU Leuven, |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I99464096 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Neurosciences, KU Leuven, Belgium |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I4210153928 |
| authorships[4].affiliations[2].raw_affiliation_string | Leuven Brain Institute, KU Leuven, Belgium |
| authorships[4].institutions[0].id | https://openalex.org/I99464096 |
| authorships[4].institutions[0].ror | https://ror.org/05f950310 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[4].institutions[0].country_code | BE |
| authorships[4].institutions[0].display_name | KU Leuven |
| authorships[4].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[4].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[4].institutions[1].country_code | BE |
| authorships[4].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[4].institutions[2].id | https://openalex.org/I1314596251 |
| authorships[4].institutions[2].ror | https://ror.org/00dcv1019 |
| authorships[4].institutions[2].type | facility |
| authorships[4].institutions[2].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[4].institutions[2].country_code | US |
| authorships[4].institutions[2].display_name | Allen Institute for Brain Science |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Steven De Vleeschouwer |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurosciences, KU Leuven, Belgium, Leuven Brain Institute , KU Leuven,, Leuven Brain Institute, KU Leuven, Belgium |
| authorships[5].author.id | https://openalex.org/A5001037498 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-7600-0806 |
| authorships[5].author.display_name | Paul M. Clément |
| authorships[5].countries | BE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I99464096 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Oncology, KU Leuven, Belgium |
| authorships[5].institutions[0].id | https://openalex.org/I99464096 |
| authorships[5].institutions[0].ror | https://ror.org/05f950310 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[5].institutions[0].country_code | BE |
| authorships[5].institutions[0].display_name | KU Leuven |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Paul M Clement |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Oncology, KU Leuven, Belgium |
| authorships[6].author.id | https://openalex.org/A5089548339 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4480-8330 |
| authorships[6].author.display_name | Charlotte Sleurs |
| authorships[6].countries | BE, NL |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I99464096 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Oncology, KU Leuven, Belgium |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I193700539 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands |
| authorships[6].institutions[0].id | https://openalex.org/I99464096 |
| authorships[6].institutions[0].ror | https://ror.org/05f950310 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[6].institutions[0].country_code | BE |
| authorships[6].institutions[0].display_name | KU Leuven |
| authorships[6].institutions[1].id | https://openalex.org/I193700539 |
| authorships[6].institutions[1].ror | https://ror.org/04b8v1s79 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I193700539 |
| authorships[6].institutions[1].country_code | NL |
| authorships[6].institutions[1].display_name | Tilburg University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Charlotte Sleurs |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands, Department of Oncology, KU Leuven, Belgium |
| authorships[7].author.id | https://openalex.org/A5066966754 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8746-2691 |
| authorships[7].author.display_name | Maarten Lambrecht |
| authorships[7].countries | BE, US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I99464096 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Radiation-Oncology, University Hospitals Leuven, Belgium |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I1314596251 |
| authorships[7].affiliations[1].raw_affiliation_string | Leuven Brain Institute , KU Leuven, |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I4210153928 |
| authorships[7].affiliations[2].raw_affiliation_string | Leuven Brain Institute, KU Leuven, Belgium |
| authorships[7].institutions[0].id | https://openalex.org/I99464096 |
| authorships[7].institutions[0].ror | https://ror.org/05f950310 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[7].institutions[0].country_code | BE |
| authorships[7].institutions[0].display_name | KU Leuven |
| authorships[7].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[7].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[7].institutions[1].country_code | BE |
| authorships[7].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[7].institutions[2].id | https://openalex.org/I1314596251 |
| authorships[7].institutions[2].ror | https://ror.org/00dcv1019 |
| authorships[7].institutions[2].type | facility |
| authorships[7].institutions[2].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[7].institutions[2].country_code | US |
| authorships[7].institutions[2].display_name | Allen Institute for Brain Science |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Maarten Lambrecht |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Radiation-Oncology, University Hospitals Leuven, Belgium, Leuven Brain Institute , KU Leuven,, Leuven Brain Institute, KU Leuven, Belgium |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13077 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9988999962806702 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Cancer-related cognitive impairment studies |
| related_works | https://openalex.org/W3208778134, https://openalex.org/W3005931108, https://openalex.org/W4386951147, https://openalex.org/W2887359201, https://openalex.org/W4308767530, https://openalex.org/W4412637781, https://openalex.org/W2362999506, https://openalex.org/W4205170363, https://openalex.org/W4223451915, https://openalex.org/W4220833452 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1093/noajnl/vdaf163 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210237914 |
| best_oa_location.source.issn | 2632-2498 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2632-2498 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Neuro-Oncology Advances |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Neuro-Oncology Advances |
| best_oa_location.landing_page_url | https://doi.org/10.1093/noajnl/vdaf163 |
| primary_location.id | doi:10.1093/noajnl/vdaf163 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210237914 |
| primary_location.source.issn | 2632-2498 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2632-2498 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Neuro-Oncology Advances |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://academic.oup.com/noa/advance-article-pdf/doi/10.1093/noajnl/vdaf163/63808228/vdaf163.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Neuro-Oncology Advances |
| primary_location.landing_page_url | https://doi.org/10.1093/noajnl/vdaf163 |
| publication_date | 2025-01-01 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2416680358, https://openalex.org/W6674292525, https://openalex.org/W2110102835, https://openalex.org/W2911294321, https://openalex.org/W2561338458, https://openalex.org/W2133433247, https://openalex.org/W6746141085, https://openalex.org/W3160274128, https://openalex.org/W2753265340, https://openalex.org/W3169809742, https://openalex.org/W4399334840, https://openalex.org/W2136567718, https://openalex.org/W2161493176, https://openalex.org/W2005476331, https://openalex.org/W1999653836, https://openalex.org/W2039112885, https://openalex.org/W2146693559, https://openalex.org/W1970597681, https://openalex.org/W3106834533, https://openalex.org/W2978356506, https://openalex.org/W4392883213, https://openalex.org/W6761560198, https://openalex.org/W2576434748, https://openalex.org/W2017658548, https://openalex.org/W6736266735, https://openalex.org/W2048512926, https://openalex.org/W2755246555, https://openalex.org/W2161594710, https://openalex.org/W3165850692, https://openalex.org/W2928374940, https://openalex.org/W3033878890, https://openalex.org/W2101135654, https://openalex.org/W2977883299, https://openalex.org/W2970898057, https://openalex.org/W4408214934, https://openalex.org/W4408739579, https://openalex.org/W2020641665, https://openalex.org/W4387398442, https://openalex.org/W2079775386, https://openalex.org/W2887975216, https://openalex.org/W3185995917, https://openalex.org/W3013656112, https://openalex.org/W3012976567, https://openalex.org/W4290096641, https://openalex.org/W4320033105, https://openalex.org/W2555694647, https://openalex.org/W4323349567, https://openalex.org/W4379284101, https://openalex.org/W2605376995, https://openalex.org/W2770668178, https://openalex.org/W3172741615, https://openalex.org/W2094522722 |
| referenced_works_count | 52 |
| abstract_inverted_index.2 | 50 |
| abstract_inverted_index.3 | 52 |
| abstract_inverted_index.= | 187, 190, 212 |
| abstract_inverted_index.P | 211 |
| abstract_inverted_index.a | 230, 272 |
| abstract_inverted_index.39 | 47 |
| abstract_inverted_index.50 | 65 |
| abstract_inverted_index.RT | 97, 106, 195, 221 |
| abstract_inverted_index.be | 279 |
| abstract_inverted_index.in | 46, 59, 203, 206, 217, 229, 233, 254, 263 |
| abstract_inverted_index.of | 23, 275 |
| abstract_inverted_index.or | 51 |
| abstract_inverted_index.to | 12, 26, 108, 118, 136, 157, 160, 223, 239 |
| abstract_inverted_index.WHO | 48 |
| abstract_inverted_index.and | 29, 39, 64, 89, 101, 112, 145, 167, 197, 214, 267 |
| abstract_inverted_index.for | 78 |
| abstract_inverted_index.may | 8, 237, 248 |
| abstract_inverted_index.per | 99 |
| abstract_inverted_index.rho | 91 |
| abstract_inverted_index.the | 13, 20, 60, 109, 137, 161, 177, 246, 264 |
| abstract_inverted_index.vs. | 209 |
| abstract_inverted_index.was | 270 |
| abstract_inverted_index.≤ | 125, 151, 174 |
| abstract_inverted_index.≥ | 122, 148, 171 |
| abstract_inverted_index.(50% | 208 |
| abstract_inverted_index.(RT) | 28 |
| abstract_inverted_index.12%, | 210 |
| abstract_inverted_index.PFDR | 124, 150, 173, 189 |
| abstract_inverted_index.This | 17 |
| abstract_inverted_index.also | 181 |
| abstract_inverted_index.dose | 98, 196, 247 |
| abstract_inverted_index.each | 79 |
| abstract_inverted_index.from | 10, 245 |
| abstract_inverted_index.gyri | 115 |
| abstract_inverted_index.hubs | 25, 82, 204, 228 |
| abstract_inverted_index.left | 61, 110, 138, 162, 178, 265 |
| abstract_inverted_index.lobe | 63 |
| abstract_inverted_index.mean | 96 |
| abstract_inverted_index.more | 201 |
| abstract_inverted_index.most | 259 |
| abstract_inverted_index.out. | 282 |
| abstract_inverted_index.pars | 139 |
| abstract_inverted_index.side | 252 |
| abstract_inverted_index.than | 205 |
| abstract_inverted_index.that | 5 |
| abstract_inverted_index.were | 42, 76, 116, 131, 155, 200, 261 |
| abstract_inverted_index.with | 31, 55, 133, 176, 183 |
| abstract_inverted_index.((37) | 170 |
| abstract_inverted_index..005) | 213 |
| abstract_inverted_index.Using | 69 |
| abstract_inverted_index.doses | 107, 135, 159 |
| abstract_inverted_index.found | 216 |
| abstract_inverted_index.grade | 49 |
| abstract_inverted_index.graph | 84 |
| abstract_inverted_index.gyrus | 169, 180 |
| abstract_inverted_index.ruled | 281 |
| abstract_inverted_index.seems | 222 |
| abstract_inverted_index.since | 258 |
| abstract_inverted_index.study | 18 |
| abstract_inverted_index.these | 243 |
| abstract_inverted_index.tumor | 276 |
| abstract_inverted_index.which | 236 |
| abstract_inverted_index.while | 127 |
| abstract_inverted_index.(r(37) | 121, 147, 186 |
| abstract_inverted_index..029). | 191 |
| abstract_inverted_index..040), | 175 |
| abstract_inverted_index..040). | 152 |
| abstract_inverted_index.Higher | 105 |
| abstract_inverted_index.Linear | 86 |
| abstract_inverted_index.affect | 225 |
| abstract_inverted_index.cannot | 278 |
| abstract_inverted_index.damage | 11 |
| abstract_inverted_index.effect | 274 |
| abstract_inverted_index.glioma | 53, 234, 255 |
| abstract_inverted_index.graphs | 75 |
| abstract_inverted_index.gyrus, | 144 |
| abstract_inverted_index.higher | 134, 158 |
| abstract_inverted_index.linked | 117, 156 |
| abstract_inverted_index.manner | 232 |
| abstract_inverted_index.memory | 119 |
| abstract_inverted_index.middle | 142 |
| abstract_inverted_index.models | 88 |
| abstract_inverted_index.motor, | 38 |
| abstract_inverted_index.poorer | 128 |
| abstract_inverted_index.region | 100 |
| abstract_inverted_index.result | 9 |
| abstract_inverted_index.0.026), | 126 |
| abstract_inverted_index.Methods | 34 |
| abstract_inverted_index.Results | 104 |
| abstract_inverted_index.between | 95, 194 |
| abstract_inverted_index.caudate | 146 |
| abstract_inverted_index.effects | 253 |
| abstract_inverted_index.frontal | 62, 143 |
| abstract_inverted_index.healthy | 67 |
| abstract_inverted_index.lesions | 56, 260 |
| abstract_inverted_index.located | 58, 262 |
| abstract_inverted_index.matched | 66 |
| abstract_inverted_index.memory, | 37 |
| abstract_inverted_index.regions | 244 |
| abstract_inverted_index.rostral | 141 |
| abstract_inverted_index.testing | 269 |
| abstract_inverted_index.through | 83 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Emerging | 2 |
| abstract_inverted_index.However, | 257 |
| abstract_inverted_index.assessed | 43, 93 |
| abstract_inverted_index.baseline | 268 |
| abstract_inverted_index.deficits | 154 |
| abstract_inverted_index.domains. | 103 |
| abstract_inverted_index.entirely | 280 |
| abstract_inverted_index.evidence | 3 |
| abstract_inverted_index.explores | 19 |
| abstract_inverted_index.frequent | 202 |
| abstract_inverted_index.fusiform | 111 |
| abstract_inverted_index.imaging, | 72 |
| abstract_inverted_index.inferior | 113 |
| abstract_inverted_index.language | 129 |
| abstract_inverted_index.location | 277 |
| abstract_inverted_index.mitigate | 250 |
| abstract_inverted_index.network. | 16 |
| abstract_inverted_index.non-hubs | 207 |
| abstract_inverted_index.outcomes | 130, 199 |
| abstract_inverted_index.patients | 54 |
| abstract_inverted_index.regions. | 219 |
| abstract_inverted_index.suggests | 4 |
| abstract_inverted_index.temporal | 114 |
| abstract_inverted_index.weighted | 73 |
| abstract_inverted_index.Attention | 153 |
| abstract_inverted_index.adversely | 224 |
| abstract_inverted_index.brain’s | 14 |
| abstract_inverted_index.cognitive | 6, 32, 102, 198, 240, 251 |
| abstract_inverted_index.controls. | 68 |
| abstract_inverted_index.executive | 40, 184 |
| abstract_inverted_index.language, | 36 |
| abstract_inverted_index.measures. | 85 |
| abstract_inverted_index.outcomes. | 33 |
| abstract_inverted_index.patients, | 235 |
| abstract_inverted_index.patients. | 256 |
| abstract_inverted_index.posterior | 163 |
| abstract_inverted_index.potential | 273 |
| abstract_inverted_index.−0.499, | 172 |
| abstract_inverted_index.−0.510, | 149 |
| abstract_inverted_index.−0.526, | 188 |
| abstract_inverted_index.−0.565, | 123 |
| abstract_inverted_index.≥1-year | 44 |
| abstract_inverted_index.Attention, | 35 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Protecting | 242 |
| abstract_inverted_index.associated | 132, 182 |
| abstract_inverted_index.cingulate, | 164 |
| abstract_inverted_index.contribute | 238 |
| abstract_inverted_index.functional | 15, 24, 71, 74, 227 |
| abstract_inverted_index.hemisphere | 266 |
| abstract_inverted_index.impairment | 120 |
| abstract_inverted_index.left-sided | 218, 226 |
| abstract_inverted_index.regression | 87 |
| abstract_inverted_index.Conclusions | 220 |
| abstract_inverted_index.Significant | 192 |
| abstract_inverted_index.constructed | 77 |
| abstract_inverted_index.dysfunction | 7, 185 |
| abstract_inverted_index.exclusively | 215 |
| abstract_inverted_index.functioning | 41 |
| abstract_inverted_index.identifying | 81 |
| abstract_inverted_index.postcentral | 168, 179 |
| abstract_inverted_index.potentially | 249 |
| abstract_inverted_index.precentral, | 165 |
| abstract_inverted_index.Spearman’s | 90 |
| abstract_inverted_index.associations | 30, 94 |
| abstract_inverted_index.correlations | 92, 193 |
| abstract_inverted_index.dysfunction. | 241 |
| abstract_inverted_index.opercularis, | 140 |
| abstract_inverted_index.participant, | 80 |
| abstract_inverted_index.radiotherapy | 27 |
| abstract_inverted_index.unavailable, | 271 |
| abstract_inverted_index.predominantly | 57 |
| abstract_inverted_index.resting-state | 70 |
| abstract_inverted_index.dose-dependent | 21, 231 |
| abstract_inverted_index.supramarginal, | 166 |
| abstract_inverted_index.susceptibility | 22 |
| abstract_inverted_index.post-radiotherapy | 45 |
| cited_by_percentile_year | |
| countries_distinct_count | 3 |
| institutions_distinct_count | 8 |
| citation_normalized_percentile.value | 0.44000684 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |