The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis Article Swipe
Minrui Yu
,
Wei Hu
,
Song Yan
,
Mengmeng Qu
,
Yan‐Mei Jiao
,
Fu‐Sheng Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12092060
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12092060
Smoking is prevalent among people living with the human immunodeficiency virus (HIV), and it increases morbidity and mortality in this population. However, due to ethical constraints, there is limited information on the effects of smoking on susceptibility to HIV infection. To investigate whether smoking is associated with an increased susceptibility to HIV infection, we conducted a two-sample Mendelian randomization (MR) study using summary statistics from genome-wide association studies of individuals of European ancestry who have ever smoked (n = 99,996) and have HIV (n = 412,130). The random-effects inverse-variance weighted estimation method was used as the study’s primary approach, with the MR-Egger regression and the weighted-median method as complementary approaches. Using 100 single-nucleotide polymorphisms of genome-wide significance as instrumental variables for smoking, we observed a significant association between smoking and HIV infection (odds ratio 5.790, 95% confidence interval [1.785, 18.787], and p = 0.003). Comparable results were obtained using the weighted-median method. Our findings implied that smoking is probably associated with increased susceptibility to HIV infection. Given the exploratory nature of this study, further research is needed to confirm this relationship.
Related Topics
Concepts
Mendelian randomization
Human immunodeficiency virus (HIV)
Mendelian inheritance
Sample (material)
Medicine
Biology
Genetics
Immunology
Gene
Genotype
Chemistry
Genetic variants
Chromatography
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines12092060
- OA Status
- gold
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402413090
All OpenAlex metadata
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https://openalex.org/W4402413090Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines12092060Digital Object Identifier
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The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-10Full publication date if available
- Authors
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Minrui Yu, Wei Hu, Song Yan, Mengmeng Qu, Yan‐Mei Jiao, Fu‐Sheng WangList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines12092060Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/biomedicines12092060Direct OA link when available
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Mendelian randomization, Human immunodeficiency virus (HIV), Mendelian inheritance, Sample (material), Medicine, Biology, Genetics, Immunology, Gene, Genotype, Chemistry, Genetic variants, ChromatographyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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