The resection of extraosseous osteosarcoma was accompanied by the occurrence of pulmonary metastasis and distal metastasis at the primary site: a case report Article Swipe
Han Liu
,
Leilei Tian
,
Jianhua Mu
,
Xuanhong He
,
Zhuangzhuang Li
,
Taojun Gong
,
Jingjing Wang
,
Min Li
,
Minxun Lu
,
Chongqi Tu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1549722
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1549722
Background Extraskeletal osteosarcoma (ESOS) is a rare and aggressive malignancy, comprising approximately 1% of all soft tissue sarcomas and 4.3% of all osteosarcomas. It predominantly affects individuals between the ages of 48 and 60, with a slightly higher incidence observed in males compared to females. The clinical diagnosis of ESOS poses a significant challenge due to its atypical presentation and overlap with other soft tissue neoplasms. Despite advances in diagnostic imaging and histopathological techniques, there is currently no consensus on the optimal treatment strategy. Case presentation We report a case of a 64-year-old Chinese woman with ESOS of the left knee for 7 years, who experienced multiple recurrences after surgical resection, accompanied by systemic multiple soft tissue metastases and lung metastases. Initially, the patient found a painless mass in the left knee, which was diagnosed as a benign soft tissue mass at a local hospital and surgically removed. However, two years after the surgery, a mass recurred around the left knee and was larger than before, prompting the patient to seek treatment at our department. The patient underwent standard surgical treatment in our department, and postoperative histopathology, genetic testing, and immunohistochemical examination all confirmed the diagnosis of ESOS. Over the course of 5 years, the patient experienced multiple recurrences, and we attempted surgical treatment combined with chemotherapy and targeted therapy. Ultimately, due to multiple tumor ruptures in the left lower limb, severe pain, and sleep disorders, the patient decided to undergo left hip disarticulation surgery. Conclusion The diagnosis and treatment of ESOS are challenging and require multimodal examination, including histological and immunohistochemical analysis. ESOS is rare, especially when it metastasizes to the distal soft tissues of the primary lesion site, which may portend a poorer clinical outcome compared to pure pulmonary metastasis. Despite current therapeutic interventions, this case still emphasizes its aggressiveness and poor prognosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2025.1549722
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1549722/pdf
- OA Status
- gold
- Cited By
- 2
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4409516945
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409516945Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2025.1549722Digital Object Identifier
- Title
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The resection of extraosseous osteosarcoma was accompanied by the occurrence of pulmonary metastasis and distal metastasis at the primary site: a case reportWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-16Full publication date if available
- Authors
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Han Liu, Leilei Tian, Jianhua Mu, Xuanhong He, Zhuangzhuang Li, Taojun Gong, Jingjing Wang, Min Li, Minxun Lu, Chongqi TuList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2025.1549722Publisher landing page
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1549722/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1549722/pdfDirect OA link when available
- Concepts
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Metastasis, Osteosarcoma, Medicine, Resection, Primary tumor, Cancer research, Pathology, Internal medicine, Surgery, CancerTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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