The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine Article Swipe
Smriti Iyengar
,
Michael H. Ossipov
,
Kirk W. Johnson
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1097/j.pain.0000000000000831
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1097/j.pain.0000000000000831
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene–related peptide was found to play important roles in cardiovascular, digestive, and sensory functions. Although the vasodilatory properties of CGRP are well documented, its somatosensory function regarding modulation of neuronal sensitization and of enhanced pain has received considerable attention recently. Growing evidence indicates that CGRP plays a key role in the development of peripheral sensitization and the associated enhanced pain. Calcitonin gene–related peptide is implicated in the development of neurogenic inflammation and it is upregulated in conditions of inflammatory and neuropathic pain. It is most likely that CGRP facilitates nociceptive transmission and contributes to the development and maintenance of a sensitized, hyperresponsive state not only of the primary afferent sensory neurons but also of the second-order pain transmission neurons within the central nervous system, thus contributing to central sensitization as well. The maintenance of a sensitized neuronal condition is believed to be an important factor underlying migraine. Recent successful clinical studies have shown that blocking the function of CGRP can alleviate migraine. However, the mechanisms through which CGRP may contribute to migraine are still not fully understood. We reviewed the role of CGRP in primary afferents, the dorsal root ganglion, and in the trigeminal system as well as its role in peripheral and central sensitization and its potential contribution to pain processing and to migraine.
Related Topics
Concepts
Calcitonin gene-related peptide
Dorsal root ganglion
Migraine
Neuroscience
Trigeminal ganglion
Medicine
Sensitization
Nociception
Nociceptor
Calcitonin
Central nervous system
Somatosensory system
Neurogenic inflammation
Neuropeptide
Sensory neuron
Sensory system
Internal medicine
Substance P
Biology
Receptor
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1097/j.pain.0000000000000831
- OA Status
- green
- Cited By
- 543
- References
- 203
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2570330573
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2570330573Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/j.pain.0000000000000831Digital Object Identifier
- Title
-
The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraineWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-04Full publication date if available
- Authors
-
Smriti Iyengar, Michael H. Ossipov, Kirk W. JohnsonList of authors in order
- Landing page
-
https://doi.org/10.1097/j.pain.0000000000000831Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1097/j.pain.0000000000000831Direct OA link when available
- Concepts
-
Calcitonin gene-related peptide, Dorsal root ganglion, Migraine, Neuroscience, Trigeminal ganglion, Medicine, Sensitization, Nociception, Nociceptor, Calcitonin, Central nervous system, Somatosensory system, Neurogenic inflammation, Neuropeptide, Sensory neuron, Sensory system, Internal medicine, Substance P, Biology, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
543Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 65, 2024: 81, 2023: 80, 2022: 87, 2021: 54Per-year citation counts (last 5 years)
- References (count)
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203Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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