The role of donor hypertension and angiotensin II in the occurrence of early pancreas allograft thrombosis Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.3389/fimmu.2024.1359381
Background About 10–20% of pancreas allografts are still lost in the early postoperative period despite the identification of numerous detrimental risk factors that correlate with graft thrombosis. Methods We conducted a multicenter study including 899 pancreas transplant recipients between 2000 and 2018. Early pancreas failure due to complete thrombosis, long-term pancreas, kidney and patient survivals were analyzed and adjusted to donor, recipient and perioperative variables using a multivariate cause-specific Cox model stratified to transplant centers. Results Pancreas from donors with history of hypertension (6.7%), as well as with high body mass index (BMI), were independently associated with an increased risk of pancreas failure within the first 30 post-operative days (respectively, HR= 2.57, 95% CI from 1.35 to 4.89 and HR= 1.11, 95% CI from 1.04 to 1.19). Interaction term between hypertension and BMI was negative. Donor hypertension also impacted long-term pancreas survival (HR= 1.88, 95% CI from 1.13 to 3.12). However, when pancreas survival was calculated after the postoperative day 30, donor hypertension was no longer a significant risk factor (HR= 1.22, 95% CI from 0.47 to 3.15). A lower pancreas survival was observed in patients receiving a pancreas from a hypertensive donor without RAAS (Renin Angiotensin Aldosterone System) blockers compared to others (50% vs 14%, p < 0.001). Pancreas survival was similar among non-hypertensive donors and hypertensive ones under RAAS blockers. Conclusion Donor hypertension was a significant and independent risk factor of pancreas failure. The well-known pathogenic role of renin-angiotensin-aldosterone system seems to be involved in the genesis of this immediate graft failure.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2024.1359381
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1359381/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399085972
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399085972Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2024.1359381Digital Object Identifier
- Title
-
The role of donor hypertension and angiotensin II in the occurrence of early pancreas allograft thrombosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-17Full publication date if available
- Authors
-
Christophe Masset, Julien Branchereau, Fanny Buron, Georges Karam, Maud Rabeyrin, Karine Renaudin, Florent Le Borgne, Lionel Badet, X. Matillon, Christophe Legendre, Denis Glotz, Corinne Antoine, Magali Giral, Jacques Dantal, Diego CantarovichList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2024.1359381Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1359381/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1359381/pdfDirect OA link when available
- Concepts
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Medicine, Pancreas, Pancreas transplantation, Internal medicine, Diabetes mellitus, Thrombosis, Perioperative, Risk factor, Gastroenterology, Body mass index, Transplantation, Surgery, Cardiology, Endocrinology, Kidney transplantationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.About | 1 |
| abstract_inverted_index.Donor | 135, 223 |
| abstract_inverted_index.Early | 42 |
| abstract_inverted_index.after | 156 |
| abstract_inverted_index.among | 213 |
| abstract_inverted_index.donor | 161, 192 |
| abstract_inverted_index.early | 11 |
| abstract_inverted_index.first | 105 |
| abstract_inverted_index.graft | 25, 252 |
| abstract_inverted_index.index | 91 |
| abstract_inverted_index.lower | 179 |
| abstract_inverted_index.model | 70 |
| abstract_inverted_index.seems | 242 |
| abstract_inverted_index.still | 7 |
| abstract_inverted_index.study | 32 |
| abstract_inverted_index.under | 219 |
| abstract_inverted_index.using | 65 |
| abstract_inverted_index.(BMI), | 92 |
| abstract_inverted_index.(Renin | 195 |
| abstract_inverted_index.1.19). | 126 |
| abstract_inverted_index.3.12). | 149 |
| abstract_inverted_index.3.15). | 177 |
| abstract_inverted_index.donor, | 60 |
| abstract_inverted_index.donors | 78, 215 |
| abstract_inverted_index.factor | 169, 231 |
| abstract_inverted_index.kidney | 51 |
| abstract_inverted_index.longer | 165 |
| abstract_inverted_index.others | 202 |
| abstract_inverted_index.period | 13 |
| abstract_inverted_index.system | 241 |
| abstract_inverted_index.within | 103 |
| abstract_inverted_index.(6.7%), | 83 |
| abstract_inverted_index.0.001). | 208 |
| abstract_inverted_index.Methods | 27 |
| abstract_inverted_index.Results | 75 |
| abstract_inverted_index.System) | 198 |
| abstract_inverted_index.between | 38, 129 |
| abstract_inverted_index.despite | 14 |
| abstract_inverted_index.factors | 21 |
| abstract_inverted_index.failure | 44, 102 |
| abstract_inverted_index.genesis | 248 |
| abstract_inverted_index.history | 80 |
| abstract_inverted_index.patient | 53 |
| abstract_inverted_index.similar | 212 |
| abstract_inverted_index.without | 193 |
| abstract_inverted_index.&lt; | 207 |
| abstract_inverted_index.10–20% | 2 |
| abstract_inverted_index.However, | 150 |
| abstract_inverted_index.Pancreas | 76, 209 |
| abstract_inverted_index.adjusted | 58 |
| abstract_inverted_index.analyzed | 56 |
| abstract_inverted_index.blockers | 199 |
| abstract_inverted_index.centers. | 74 |
| abstract_inverted_index.compared | 200 |
| abstract_inverted_index.complete | 47 |
| abstract_inverted_index.failure. | 234, 253 |
| abstract_inverted_index.impacted | 138 |
| abstract_inverted_index.involved | 245 |
| abstract_inverted_index.numerous | 18 |
| abstract_inverted_index.observed | 183 |
| abstract_inverted_index.pancreas | 4, 35, 43, 101, 140, 152, 180, 188, 233 |
| abstract_inverted_index.patients | 185 |
| abstract_inverted_index.survival | 141, 153, 181, 210 |
| abstract_inverted_index.blockers. | 221 |
| abstract_inverted_index.conducted | 29 |
| abstract_inverted_index.correlate | 23 |
| abstract_inverted_index.immediate | 251 |
| abstract_inverted_index.including | 33 |
| abstract_inverted_index.increased | 98 |
| abstract_inverted_index.long-term | 49, 139 |
| abstract_inverted_index.negative. | 134 |
| abstract_inverted_index.pancreas, | 50 |
| abstract_inverted_index.receiving | 186 |
| abstract_inverted_index.recipient | 61 |
| abstract_inverted_index.survivals | 54 |
| abstract_inverted_index.variables | 64 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 222 |
| abstract_inverted_index.allografts | 5 |
| abstract_inverted_index.associated | 95 |
| abstract_inverted_index.calculated | 155 |
| abstract_inverted_index.pathogenic | 237 |
| abstract_inverted_index.recipients | 37 |
| abstract_inverted_index.stratified | 71 |
| abstract_inverted_index.transplant | 36, 73 |
| abstract_inverted_index.well-known | 236 |
| abstract_inverted_index.Aldosterone | 197 |
| abstract_inverted_index.Angiotensin | 196 |
| abstract_inverted_index.Interaction | 127 |
| abstract_inverted_index.detrimental | 19 |
| abstract_inverted_index.independent | 229 |
| abstract_inverted_index.multicenter | 31 |
| abstract_inverted_index.significant | 167, 227 |
| abstract_inverted_index.thrombosis, | 48 |
| abstract_inverted_index.thrombosis. | 26 |
| abstract_inverted_index.hypertension | 82, 130, 136, 162, 224 |
| abstract_inverted_index.hypertensive | 191, 217 |
| abstract_inverted_index.multivariate | 67 |
| abstract_inverted_index.independently | 94 |
| abstract_inverted_index.perioperative | 63 |
| abstract_inverted_index.postoperative | 12, 158 |
| abstract_inverted_index.(respectively, | 109 |
| abstract_inverted_index.cause-specific | 68 |
| abstract_inverted_index.identification | 16 |
| abstract_inverted_index.post-operative | 107 |
| abstract_inverted_index.non-hypertensive | 214 |
| abstract_inverted_index.renin-angiotensin-aldosterone | 240 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5055007301 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210112643, https://openalex.org/I4392021198, https://openalex.org/I97188460 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.85264194 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |