The Role of Killer Ig-like Receptors in Diseases from A to Z Article Swipe
Luisa Agnello
,
Anna Masucci
,
Martina Tamburello
,
Roberta Vassallo
,
Davide Massa
,
Rosaria Vincenza Giglio
,
Mauro Midiri
,
Caterina Maria Gambino
,
Marcello Ciaccio
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26073242
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26073242
Killer Ig-like Receptors (KIRs) regulate immune responses, maintaining the balance between activation and inhibition of the immune system. KIRs are expressed on natural killer cells and some CD8 T cells and interact with HLA class I molecules, influencing various physiological and pathological processes. KIRs’ polymorphism creates a variability in immune responses among individuals. KIRs are involved in autoimmune disorders, cancer, infections, neurological diseases, and other diseases. Specific combinations of KIRs and HLA are linked to several diseases’ susceptibility, progression, and outcomes. In particular, the balance between inhibitory and activating KIRs can determine how the immune system responds to pathogens and tumors. An imbalance can lead to an excessive response, contributing to autoimmune diseases, or an inadequate response, allowing immune evasion by pathogens or cancer cells. The increasing number of studies on KIRs highlights their essential role as diagnostic and prognostic biomarkers and potential therapeutic targets. This review provides a comprehensive overview of the role of KIRs in all clinical conditions and diseases, listed alphabetically, where they are analyzed.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms26073242
- https://www.mdpi.com/1422-0067/26/7/3242/pdf?version=1743501158
- OA Status
- gold
- Cited By
- 4
- References
- 416
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4409039766Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms26073242Digital Object Identifier
- Title
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The Role of Killer Ig-like Receptors in Diseases from A to ZWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-31Full publication date if available
- Authors
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Luisa Agnello, Anna Masucci, Martina Tamburello, Roberta Vassallo, Davide Massa, Rosaria Vincenza Giglio, Mauro Midiri, Caterina Maria Gambino, Marcello CiaccioList of authors in order
- Landing page
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https://doi.org/10.3390/ijms26073242Publisher landing page
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https://www.mdpi.com/1422-0067/26/7/3242/pdf?version=1743501158Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/26/7/3242/pdf?version=1743501158Direct OA link when available
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Receptor, Biology, Computational biology, Immunology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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