The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosis Article Swipe
Osama A. Mohammed
,
Ahmed S. Doghish
,
Mohannad Mohammad S. Alamri
,
Muffarah Hamid Alharthi
,
Jaber Alfaifi
,
M. Adam
,
Abdullah Hassan Alhalafi
,
AbdulElah Al Jarallah AlQahtani
,
Assad Ali Rezigalla
,
Magaji Garba Taura
,
Adamu Imam Isa
,
Ahad Fuad Binafif
,
Mohammed A. Attia
,
Elsayed A. Elmorsy
,
Ayman Abd Al-Maksoud Yousef
,
Mustafa Ahmed Abdel‐Reheim
,
Mohamed A. Elkady
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e27694
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e27694
The current investigation found that miR-196a2 expression was significantly higher in the control group than in asthmatic patients as a whole. The study found that severe asthmatics had higher MMP-2, IL-6, and IgE serum levels than healthy controls. We identified the MMP-2 serum concentration cutoff with great sensitivity and specificity. Significant relationships between MMP-2 serum level and miR-196a2 expression in the patient group with severe asthmatics were found. The MMP-2, IL-6, and IgE serum levels were considerably higher in mild, moderate, and severe asthmatics than controls. The miR-196a2 expression and MMP-2 serum concentration correlated positively with IgE and blood eosinophils % and negatively with all lung function tests in the asthmatic patient group.Conclusion: the study revealed that the elevated miR-196a2 expression and serum concentration of MMP-2, IL-6, and IgE associated with elevated blood eosinophils % is associated with pathophysiology and degree of asthma severity. The miR-196a2 expression and MMP-2 serum concentration have a promising diagnostic and prognostic ability in bronchial asthma.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.heliyon.2024.e27694
- http://www.cell.com/article/S2405844024037253/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392714146
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392714146Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.heliyon.2024.e27694Digital Object Identifier
- Title
-
The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Osama A. Mohammed, Ahmed S. Doghish, Mohannad Mohammad S. Alamri, Muffarah Hamid Alharthi, Jaber Alfaifi, M. Adam, Abdullah Hassan Alhalafi, AbdulElah Al Jarallah AlQahtani, Assad Ali Rezigalla, Magaji Garba Taura, Adamu Imam Isa, Ahad Fuad Binafif, Mohammed A. Attia, Elsayed A. Elmorsy, Ayman Abd Al-Maksoud Yousef, Mustafa Ahmed Abdel‐Reheim, Mohamed A. ElkadyList of authors in order
- Landing page
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https://doi.org/10.1016/j.heliyon.2024.e27694Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2405844024037253/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2405844024037253/pdfDirect OA link when available
- Concepts
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Asthma, Medicine, Immunology, Pathogenesis, Immunoglobulin E, Matrix metalloproteinase, Clinical significance, Inflammation, Basement membrane, Allergy, Biomarker, Internal medicine, Antibody, Pathology, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works_count | 60 |
| abstract_inverted_index.% | 100, 134 |
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| abstract_inverted_index.and | 31, 48, 56, 71, 81, 89, 97, 101, 121, 127, 139, 147, 155 |
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| abstract_inverted_index.with | 45, 63, 95, 103, 130, 137 |
| abstract_inverted_index.IL-6, | 30, 70, 126 |
| abstract_inverted_index.MMP-2 | 41, 53, 90, 148 |
| abstract_inverted_index.blood | 98, 132 |
| abstract_inverted_index.found | 3, 23 |
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| abstract_inverted_index.group | 13, 62 |
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| abstract_inverted_index.miR-196a2 | 5, 57, 87, 119, 145 |
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| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5047636294, https://openalex.org/A5035913177 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I113643904, https://openalex.org/I184834183, https://openalex.org/I206935292, https://openalex.org/I4210151980 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7300000190734863 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83540867 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |