The Role of Skin Immune System in Acne Article Swipe
Ewelina Firlej
,
Wioleta Kowalska
,
Karolina Szymaszek
,
Jacek Roliński
,
Joanna Bartosińska
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11061579
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11061579
Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm11061579
- https://www.mdpi.com/2077-0383/11/6/1579/pdf?version=1647160114
- OA Status
- gold
- Cited By
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- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4220750759Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/jcm11061579Digital Object Identifier
- Title
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The Role of Skin Immune System in AcneWork title
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reviewOpenAlex work type
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-13Full publication date if available
- Authors
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Ewelina Firlej, Wioleta Kowalska, Karolina Szymaszek, Jacek Roliński, Joanna BartosińskaList of authors in order
- Landing page
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https://doi.org/10.3390/jcm11061579Publisher landing page
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https://www.mdpi.com/2077-0383/11/6/1579/pdf?version=1647160114Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/11/6/1579/pdf?version=1647160114Direct OA link when available
- Concepts
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Medicine, Acne, Dermatology, Immune system, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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62Total citation count in OpenAlex
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2025: 15, 2024: 27, 2023: 18, 2022: 2Per-year citation counts (last 5 years)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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