The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth Article Swipe

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Lei Wang , Chaobo Li , Shu‐Yi Huang , Bin Fan , Cong Wang , Zhihong Yao , Yihao Yang , Lei Han , Daqi Jia , Zuozhang Yang ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.21037/tcr-2025-713

Our study indicates that elevated expression of YTHDF1 is a predictor of poor prognosis in patients with LUAD and may serve as a potential diagnostic biomarker and therapeutic target for this disease. In addition, we identified LY-411575 as a YTHDF1 inhibitor that effectively inhibits the proliferation of LUAD cells in vivo and in vitro, highlighting its potential as a LUAD targeted therapy.

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Type: article
Language: en
Landing Page: https://doi.org/10.21037/tcr-2025-713
OA Status: diamond
OpenAlex ID: https://openalex.org/W4415696222

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OpenAlex ID: https://openalex.org/W4415696222

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DOI: https://doi.org/10.21037/tcr-2025-713

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Title: The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-09-01

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Authors: Lei Wang, Chaobo Li, Shu‐Yi Huang, Bin Fan, Cong Wang, Zhihong Yao, Yihao Yang, Lei Han, Daqi Jia, Zuozhang Yang

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Landing page: https://doi.org/10.21037/tcr-2025-713

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