The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration Article Swipe
Shanez Haouari
,
Patrick Vourc’h
,
Médéric Jeanne
,
Sylviane Marouillat
,
Charlotte Veyrat‐Durebex
,
Débora Lanznaster
,
Frédéric Laumonnier
,
Philippe Corcia
,
Hélène Blasco
,
Christian Andrés
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23073882
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23073882
The ubiquitin pathway regulates the function of many proteins and controls cellular protein homeostasis. In recent years, it has attracted great interest in neurodevelopmental and neurodegenerative diseases. Here, we have presented the first review on the roles of the 9 proteins of the HECT E3 ligase NEDD4 subfamily in the development and function of neurons in the central nervous system (CNS). We discussed their regulation and their direct or indirect involvement in neurodevelopmental diseases, such as intellectual disability, and neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease or Amyotrophic Lateral Sclerosis. Further studies on the roles of these proteins, their regulation and their targets in neurons will certainly contribute to a better understanding of neuronal function and dysfunction, and will also provide interesting information for the development of therapeutics targeting them.
Related Topics
Concepts
NEDD4
Neurodegeneration
Ubiquitin
Subfamily
Neuroscience
Biology
Ubiquitin ligase
Medicine
Genetics
Internal medicine
Disease
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms23073882
- https://www.mdpi.com/1422-0067/23/7/3882/pdf?version=1648788217
- OA Status
- gold
- Cited By
- 36
- References
- 126
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220659847
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4220659847Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms23073882Digital Object Identifier
- Title
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The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and NeurodegenerationWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-31Full publication date if available
- Authors
-
Shanez Haouari, Patrick Vourc’h, Médéric Jeanne, Sylviane Marouillat, Charlotte Veyrat‐Durebex, Débora Lanznaster, Frédéric Laumonnier, Philippe Corcia, Hélène Blasco, Christian AndrésList of authors in order
- Landing page
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https://doi.org/10.3390/ijms23073882Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/23/7/3882/pdf?version=1648788217Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/23/7/3882/pdf?version=1648788217Direct OA link when available
- Concepts
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NEDD4, Neurodegeneration, Ubiquitin, Subfamily, Neuroscience, Biology, Ubiquitin ligase, Medicine, Genetics, Internal medicine, Disease, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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36Total citation count in OpenAlex
- Citations by year (recent)
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2025: 12, 2024: 15, 2023: 5, 2022: 4Per-year citation counts (last 5 years)
- References (count)
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126Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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