The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human Monocytes Article Swipe
Patricia Urbán
,
Paola Italiani
,
Diana Boraschi
,
Sabrina Gioria
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.963627
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.963627
The interaction of SARS-CoV-2 with the human immune system is at the basis of the positive or negative outcome of the infection. Monocytes and macrophages, which are major innate immune/inflammatory effector cells, are not directly infected by SARS-CoV-2, however they can react to the virus and mount a strong reaction. Whether this first interaction and reaction may bias innate reactivity to re-challenge, a phenomenon known as innate memory, is currently unexplored and may be part of the long-term sequelae of COVID-19. Here, we have tested the capacity of SARS-CoV-2 and some of its proteins to induce innate memory in human monocytes in vitro . Our preliminary results show that the Spike protein subunits S1 and S2 and the entire heat-inactivated virus have no substantial effect. Conversely, monocytes pre-exposed to the nucleocapsid N protein react to subsequent viral or bacterial challenges with an increased production of anti-inflammatory IL-1Ra, a response profile suggesting a milder response to new infections.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.963627
- OA Status
- gold
- Cited By
- 7
- References
- 39
- Related Works
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- OpenAlex ID
- https://openalex.org/W4285797802
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285797802Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2022.963627Digital Object Identifier
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The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human MonocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-07-19Full publication date if available
- Authors
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Patricia Urbán, Paola Italiani, Diana Boraschi, Sabrina GioriaList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2022.963627Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fimmu.2022.963627Direct OA link when available
- Concepts
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Innate immune system, Virus, Immunology, Effector, Virology, Biology, Nucleoprotein, Inflammation, Immune systemTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 3, 2024: 1, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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