The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Article Swipe
Junghoon Lee
,
Scot P. Ouellette
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.104240
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.104240
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these forms are unknown. Here, we present evidence that cyclic di-AMP (c-di-AMP) is a key factor in triggering the transition from RB to EB (i.e., secondary differentiation) in the chlamydial developmental cycle. By overexpressing or knocking down expression of c-di-AMP synthase genes, we made strains producing different levels of c-di-AMP, which we linked to changes in secondary differentiation status. Increases in c-di-AMP resulted in an earlier increase in transcription of EB-associated genes, and this was further manifested in earlier production of EBs. In contrast, when c-di-AMP levels were decreased, developmental cycle progression was delayed. Based on these data, we conclude there is a threshold level of c-di-AMP needed to trigger secondary differentiation in Chlamydia . This study identifies a mechanism by which secondary differentiation is initiated in Chlamydia and reveals a critical role for the second messenger signaling molecule c-di-AMP in this process.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.104240
- OA Status
- gold
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406895662
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406895662Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.104240Digital Object Identifier
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The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatisWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
- Publication date
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2025-01-28Full publication date if available
- Authors
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Junghoon Lee, Scot P. OuelletteList of authors in order
- Landing page
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https://doi.org/10.7554/elife.104240Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.104240Direct OA link when available
- Concepts
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Chlamydia trachomatis, Biology, Chlamydia, Cell biology, Physics, Virology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
- References (count)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2119656536, https://openalex.org/W1719723029, https://openalex.org/W2011930613, https://openalex.org/W6634771800, https://openalex.org/W1869726924, https://openalex.org/W1783285978, https://openalex.org/W2510789424, https://openalex.org/W2346633051, https://openalex.org/W2139972143, https://openalex.org/W3006240911, https://openalex.org/W2017111499, https://openalex.org/W2121701946, https://openalex.org/W2135783899, https://openalex.org/W2075583035, https://openalex.org/W1843541362, https://openalex.org/W2142105619, https://openalex.org/W1780853035, https://openalex.org/W2972929810, https://openalex.org/W2914875038, https://openalex.org/W2196923764, https://openalex.org/W2157046025, https://openalex.org/W2942856089, https://openalex.org/W2165079807, https://openalex.org/W2152861858, https://openalex.org/W2137288582, https://openalex.org/W2611425968, https://openalex.org/W2054871938, https://openalex.org/W2115780677, https://openalex.org/W3154164226, https://openalex.org/W3092217152, https://openalex.org/W2124733101, https://openalex.org/W2150737519, https://openalex.org/W4387003247, https://openalex.org/W3084277729, https://openalex.org/W4404637955, https://openalex.org/W4297218728, https://openalex.org/W4406529894, https://openalex.org/W1670617703, https://openalex.org/W4309245464, https://openalex.org/W2981679577, https://openalex.org/W2093259951, https://openalex.org/W2118805096, https://openalex.org/W1847018147, https://openalex.org/W1929658003, https://openalex.org/W2153833219, https://openalex.org/W4366821613, https://openalex.org/W4220731037, https://openalex.org/W3121064739, https://openalex.org/W2912371761, https://openalex.org/W2059833435, https://openalex.org/W2126922170, https://openalex.org/W4327583115, https://openalex.org/W2046684285, https://openalex.org/W1938173378, https://openalex.org/W1560410275, https://openalex.org/W2158573520, https://openalex.org/W2170331865, https://openalex.org/W2602011001, https://openalex.org/W2152434206, https://openalex.org/W4395694956, https://openalex.org/W1581158476, https://openalex.org/W2793996708, https://openalex.org/W1923725911, https://openalex.org/W2398545537 |
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