The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro Article Swipe
J. A. Ramirez
,
María Camila Jiménez
,
Valentina Ospina
,
Brian Rivera
,
Susana Fiorentino
,
Alfonso Barreto
,
Luz Marina Restrepo Múnera
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00418-024-02265-1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00418-024-02265-1
Cancer is understood as a multifactorial disease that involve multiple cell types and phenotypes in the tumor microenvironment (TME). The components of the TME can interact directly or via soluble factors (cytokines, chemokines, growth factors, extracellular vesicles, etc.). Among the cells composing the TME, mesenchymal stem cells (MSCs) appear as a population with debated properties since it has been seen that they can both promote or attenuate tumor progression. For various authors, the main mechanism of interaction of MSCs is through their secretome, the set of molecules secreted into the extracellular milieu, recruiting, and influencing the behavior of other cells in inflammatory environments where they normally reside, such as wounds and tumors. Natural products have been studied as possible cancer treatments, appealing to synergisms between the molecules in their composition; thus, extracts obtained from Petiveria alliacea (Anamu-SC) and Caesalpinia spinosa (P2Et) have been produced and studied previously on different models, showing promising results. The effect of plant extracts on the MSC secretome has been poorly studied, especially in the context of the TME. Here, we studied the effect of Anamu-SC and P2Et extracts in the human adipose-derived MSC (hAMSC)–tumor cell interaction as a TME model. We also investigated the influence of the hAMSC secretome, in combination with these natural products, on tumor cell hallmarks such as viability, clonogenicity, and migration. In addition, hAMSC gene expression and protein synthesis were evaluated for some key factors in tumor progression in the presence of the extracts by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Multiplex, respectively. It was found that the presence of the hAMSC secretome did not affect the cytotoxic or clonogenicity-reducing activities of the natural extracts on cancer cells, and even this secretome can inhibit the migration of these tumor cells, in addition to the fact that the profile of molecules can be modified by natural products. Overall, our findings demonstrate that hAMSC secretome participation in TME interactions can favor the antitumor activities of natural products.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00418-024-02265-1
- https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdf
- OA Status
- hybrid
- Cited By
- 2
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392130542
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392130542Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00418-024-02265-1Digital Object Identifier
- Title
-
The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitroWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-24Full publication date if available
- Authors
-
J. A. Ramirez, María Camila Jiménez, Valentina Ospina, Brian Rivera, Susana Fiorentino, Alfonso Barreto, Luz Marina Restrepo MúneraList of authors in order
- Landing page
-
https://doi.org/10.1007/s00418-024-02265-1Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdfDirect OA link when available
- Concepts
-
Mesenchymal stem cell, Tumor microenvironment, Cell biology, Biology, Population, Extracellular matrix, Chemokine, Cancer stem cell, Proinflammatory cytokine, Stem cell, Chemistry, Cancer research, Immunology, Immune system, Inflammation, Tumor cells, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2Per-year citation counts (last 5 years)
- References (count)
-
59Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4392130542 |
|---|---|
| doi | https://doi.org/10.1007/s00418-024-02265-1 |
| ids.doi | https://doi.org/10.1007/s00418-024-02265-1 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38402366 |
| ids.openalex | https://openalex.org/W4392130542 |
| fwci | 1.90345994 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D059630 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Mesenchymal Stem Cells |
| mesh[2].qualifier_ui | Q000166 |
| mesh[2].descriptor_ui | D059630 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | cytology |
| mesh[2].descriptor_name | Mesenchymal Stem Cells |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D059630 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Mesenchymal Stem Cells |
| mesh[4].qualifier_ui | Q000494 |
| mesh[4].descriptor_ui | D010936 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | pharmacology |
| mesh[4].descriptor_name | Plant Extracts |
| mesh[5].qualifier_ui | Q000737 |
| mesh[5].descriptor_ui | D010936 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | chemistry |
| mesh[5].descriptor_name | Plant Extracts |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D000089282 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Secretome |
| mesh[7].qualifier_ui | Q000494 |
| mesh[7].descriptor_ui | D000972 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pharmacology |
| mesh[7].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[8].qualifier_ui | Q000737 |
| mesh[8].descriptor_ui | D000972 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | chemistry |
| mesh[8].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D002478 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Cells, Cultured |
| mesh[10].qualifier_ui | Q000187 |
| mesh[10].descriptor_ui | D049109 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | drug effects |
| mesh[10].descriptor_name | Cell Proliferation |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D004354 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Drug Screening Assays, Antitumor |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D059630 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Mesenchymal Stem Cells |
| mesh[14].qualifier_ui | Q000166 |
| mesh[14].descriptor_ui | D059630 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | cytology |
| mesh[14].descriptor_name | Mesenchymal Stem Cells |
| mesh[15].qualifier_ui | Q000187 |
| mesh[15].descriptor_ui | D059630 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | drug effects |
| mesh[15].descriptor_name | Mesenchymal Stem Cells |
| mesh[16].qualifier_ui | Q000494 |
| mesh[16].descriptor_ui | D010936 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | pharmacology |
| mesh[16].descriptor_name | Plant Extracts |
| mesh[17].qualifier_ui | Q000737 |
| mesh[17].descriptor_ui | D010936 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | chemistry |
| mesh[17].descriptor_name | Plant Extracts |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D000089282 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Secretome |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D000972 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[20].qualifier_ui | Q000737 |
| mesh[20].descriptor_ui | D000972 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | chemistry |
| mesh[20].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D002478 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Cells, Cultured |
| mesh[22].qualifier_ui | Q000187 |
| mesh[22].descriptor_ui | D049109 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | drug effects |
| mesh[22].descriptor_name | Cell Proliferation |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D004354 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Drug Screening Assays, Antitumor |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D059630 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Mesenchymal Stem Cells |
| mesh[26].qualifier_ui | Q000166 |
| mesh[26].descriptor_ui | D059630 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | cytology |
| mesh[26].descriptor_name | Mesenchymal Stem Cells |
| mesh[27].qualifier_ui | Q000187 |
| mesh[27].descriptor_ui | D059630 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug effects |
| mesh[27].descriptor_name | Mesenchymal Stem Cells |
| mesh[28].qualifier_ui | Q000494 |
| mesh[28].descriptor_ui | D010936 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | pharmacology |
| mesh[28].descriptor_name | Plant Extracts |
| mesh[29].qualifier_ui | Q000737 |
| mesh[29].descriptor_ui | D010936 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | chemistry |
| mesh[29].descriptor_name | Plant Extracts |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D000089282 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Secretome |
| mesh[31].qualifier_ui | Q000494 |
| mesh[31].descriptor_ui | D000972 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pharmacology |
| mesh[31].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[32].qualifier_ui | Q000737 |
| mesh[32].descriptor_ui | D000972 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | chemistry |
| mesh[32].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D002478 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Cells, Cultured |
| mesh[34].qualifier_ui | Q000187 |
| mesh[34].descriptor_ui | D049109 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | drug effects |
| mesh[34].descriptor_name | Cell Proliferation |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D004354 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Drug Screening Assays, Antitumor |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D059630 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Mesenchymal Stem Cells |
| mesh[38].qualifier_ui | Q000166 |
| mesh[38].descriptor_ui | D059630 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | cytology |
| mesh[38].descriptor_name | Mesenchymal Stem Cells |
| mesh[39].qualifier_ui | Q000187 |
| mesh[39].descriptor_ui | D059630 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | drug effects |
| mesh[39].descriptor_name | Mesenchymal Stem Cells |
| mesh[40].qualifier_ui | Q000494 |
| mesh[40].descriptor_ui | D010936 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | pharmacology |
| mesh[40].descriptor_name | Plant Extracts |
| mesh[41].qualifier_ui | Q000737 |
| mesh[41].descriptor_ui | D010936 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | chemistry |
| mesh[41].descriptor_name | Plant Extracts |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D000089282 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Secretome |
| mesh[43].qualifier_ui | Q000494 |
| mesh[43].descriptor_ui | D000972 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | pharmacology |
| mesh[43].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[44].qualifier_ui | Q000737 |
| mesh[44].descriptor_ui | D000972 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | chemistry |
| mesh[44].descriptor_name | Antineoplastic Agents, Phytogenic |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D002478 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Cells, Cultured |
| mesh[46].qualifier_ui | Q000187 |
| mesh[46].descriptor_ui | D049109 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | drug effects |
| mesh[46].descriptor_name | Cell Proliferation |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D004354 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Drug Screening Assays, Antitumor |
| type | article |
| title | The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro |
| biblio.issue | 5 |
| biblio.volume | 161 |
| biblio.last_page | 421 |
| biblio.first_page | 409 |
| topics[0].id | https://openalex.org/T10176 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9973999857902527 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2716 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Mesenchymal stem cell research |
| topics[1].id | https://openalex.org/T10336 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9671000242233276 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Cancer Cells and Metastasis |
| topics[2].id | https://openalex.org/T11319 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9553999900817871 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1313 |
| topics[2].subfield.display_name | Molecular Medicine |
| topics[2].display_name | Curcumin's Biomedical Applications |
| is_xpac | False |
| apc_list.value | 3190 |
| apc_list.currency | EUR |
| apc_list.value_usd | 4190 |
| apc_paid.value | 3190 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 4190 |
| concepts[0].id | https://openalex.org/C198826908 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7454456090927124 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1922379 |
| concepts[0].display_name | Mesenchymal stem cell |
| concepts[1].id | https://openalex.org/C2776107976 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5857372283935547 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1786433 |
| concepts[1].display_name | Tumor microenvironment |
| concepts[2].id | https://openalex.org/C95444343 |
| concepts[2].level | 1 |
| concepts[2].score | 0.536787211894989 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[2].display_name | Cell biology |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5365446209907532 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C2908647359 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4699445068836212 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[4].display_name | Population |
| concepts[5].id | https://openalex.org/C189165786 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4639316201210022 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q193825 |
| concepts[5].display_name | Extracellular matrix |
| concepts[6].id | https://openalex.org/C13373296 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4535480737686157 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q421866 |
| concepts[6].display_name | Chemokine |
| concepts[7].id | https://openalex.org/C55427017 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4301702678203583 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1638475 |
| concepts[7].display_name | Cancer stem cell |
| concepts[8].id | https://openalex.org/C164027704 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4227822721004486 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3491837 |
| concepts[8].display_name | Proinflammatory cytokine |
| concepts[9].id | https://openalex.org/C28328180 |
| concepts[9].level | 2 |
| concepts[9].score | 0.40399137139320374 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[9].display_name | Stem cell |
| concepts[10].id | https://openalex.org/C185592680 |
| concepts[10].level | 0 |
| concepts[10].score | 0.33668196201324463 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[10].display_name | Chemistry |
| concepts[11].id | https://openalex.org/C502942594 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3271474838256836 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[11].display_name | Cancer research |
| concepts[12].id | https://openalex.org/C203014093 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2432641088962555 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[12].display_name | Immunology |
| concepts[13].id | https://openalex.org/C8891405 |
| concepts[13].level | 2 |
| concepts[13].score | 0.18068915605545044 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[13].display_name | Immune system |
| concepts[14].id | https://openalex.org/C2776914184 |
| concepts[14].level | 2 |
| concepts[14].score | 0.14371362328529358 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[14].display_name | Inflammation |
| concepts[15].id | https://openalex.org/C3020616263 |
| concepts[15].level | 2 |
| concepts[15].score | 0.1271008551120758 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q1216998 |
| concepts[15].display_name | Tumor cells |
| concepts[16].id | https://openalex.org/C71924100 |
| concepts[16].level | 0 |
| concepts[16].score | 0.11481404304504395 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[16].display_name | Medicine |
| concepts[17].id | https://openalex.org/C99454951 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[17].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/mesenchymal-stem-cell |
| keywords[0].score | 0.7454456090927124 |
| keywords[0].display_name | Mesenchymal stem cell |
| keywords[1].id | https://openalex.org/keywords/tumor-microenvironment |
| keywords[1].score | 0.5857372283935547 |
| keywords[1].display_name | Tumor microenvironment |
| keywords[2].id | https://openalex.org/keywords/cell-biology |
| keywords[2].score | 0.536787211894989 |
| keywords[2].display_name | Cell biology |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.5365446209907532 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/population |
| keywords[4].score | 0.4699445068836212 |
| keywords[4].display_name | Population |
| keywords[5].id | https://openalex.org/keywords/extracellular-matrix |
| keywords[5].score | 0.4639316201210022 |
| keywords[5].display_name | Extracellular matrix |
| keywords[6].id | https://openalex.org/keywords/chemokine |
| keywords[6].score | 0.4535480737686157 |
| keywords[6].display_name | Chemokine |
| keywords[7].id | https://openalex.org/keywords/cancer-stem-cell |
| keywords[7].score | 0.4301702678203583 |
| keywords[7].display_name | Cancer stem cell |
| keywords[8].id | https://openalex.org/keywords/proinflammatory-cytokine |
| keywords[8].score | 0.4227822721004486 |
| keywords[8].display_name | Proinflammatory cytokine |
| keywords[9].id | https://openalex.org/keywords/stem-cell |
| keywords[9].score | 0.40399137139320374 |
| keywords[9].display_name | Stem cell |
| keywords[10].id | https://openalex.org/keywords/chemistry |
| keywords[10].score | 0.33668196201324463 |
| keywords[10].display_name | Chemistry |
| keywords[11].id | https://openalex.org/keywords/cancer-research |
| keywords[11].score | 0.3271474838256836 |
| keywords[11].display_name | Cancer research |
| keywords[12].id | https://openalex.org/keywords/immunology |
| keywords[12].score | 0.2432641088962555 |
| keywords[12].display_name | Immunology |
| keywords[13].id | https://openalex.org/keywords/immune-system |
| keywords[13].score | 0.18068915605545044 |
| keywords[13].display_name | Immune system |
| keywords[14].id | https://openalex.org/keywords/inflammation |
| keywords[14].score | 0.14371362328529358 |
| keywords[14].display_name | Inflammation |
| keywords[15].id | https://openalex.org/keywords/tumor-cells |
| keywords[15].score | 0.1271008551120758 |
| keywords[15].display_name | Tumor cells |
| keywords[16].id | https://openalex.org/keywords/medicine |
| keywords[16].score | 0.11481404304504395 |
| keywords[16].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.1007/s00418-024-02265-1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S78725770 |
| locations[0].source.issn | 0948-6143, 1432-119X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0948-6143 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Histochemistry and Cell Biology |
| locations[0].source.host_organization | https://openalex.org/P4310319900 |
| locations[0].source.host_organization_name | Springer Science+Business Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319900 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Histochemistry and Cell Biology |
| locations[0].landing_page_url | https://doi.org/10.1007/s00418-024-02265-1 |
| locations[1].id | pmid:38402366 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Histochemistry and cell biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38402366 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11045572 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Histochem Cell Biol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11045572 |
| locations[3].id | pmh:oai:repository.javeriana.edu.co:10554/70077 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401316 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Repositorio Institucional (Pontificia Universidad Javeriana) |
| locations[3].source.host_organization | https://openalex.org/I233745408 |
| locations[3].source.host_organization_name | Pontificia Universidad Javeriana |
| locations[3].source.host_organization_lineage | https://openalex.org/I233745408 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Artículo de revista |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://hdl.handle.net/10554/70077 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5019800618 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5911-2088 |
| authorships[0].author.display_name | J. A. Ramirez |
| authorships[0].countries | CO |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I35961687 |
| authorships[0].affiliations[0].raw_affiliation_string | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[0].institutions[0].id | https://openalex.org/I35961687 |
| authorships[0].institutions[0].ror | https://ror.org/03bp5hc83 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I35961687 |
| authorships[0].institutions[0].country_code | CO |
| authorships[0].institutions[0].display_name | Universidad de Antioquia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | J. A. Ramirez |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[1].author.id | https://openalex.org/A5040390320 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3075-9854 |
| authorships[1].author.display_name | María Camila Jiménez |
| authorships[1].countries | CO |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I233745408 |
| authorships[1].affiliations[0].raw_affiliation_string | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[1].institutions[0].id | https://openalex.org/I233745408 |
| authorships[1].institutions[0].ror | https://ror.org/03etyjw28 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I233745408 |
| authorships[1].institutions[0].country_code | CO |
| authorships[1].institutions[0].display_name | Pontificia Universidad Javeriana |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | M. C. Jiménez |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[2].author.id | https://openalex.org/A5036096469 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4952-2304 |
| authorships[2].author.display_name | Valentina Ospina |
| authorships[2].countries | CO |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I35961687 |
| authorships[2].affiliations[0].raw_affiliation_string | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[2].institutions[0].id | https://openalex.org/I35961687 |
| authorships[2].institutions[0].ror | https://ror.org/03bp5hc83 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I35961687 |
| authorships[2].institutions[0].country_code | CO |
| authorships[2].institutions[0].display_name | Universidad de Antioquia |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | V. Ospina |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[3].author.id | https://openalex.org/A5007297940 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2678-8150 |
| authorships[3].author.display_name | Brian Rivera |
| authorships[3].countries | CO |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I35961687 |
| authorships[3].affiliations[0].raw_affiliation_string | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[3].institutions[0].id | https://openalex.org/I35961687 |
| authorships[3].institutions[0].ror | https://ror.org/03bp5hc83 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I35961687 |
| authorships[3].institutions[0].country_code | CO |
| authorships[3].institutions[0].display_name | Universidad de Antioquia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | B. S. Rivera |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[4].author.id | https://openalex.org/A5039187859 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4664-0682 |
| authorships[4].author.display_name | Susana Fiorentino |
| authorships[4].countries | CO |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I233745408 |
| authorships[4].affiliations[0].raw_affiliation_string | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[4].institutions[0].id | https://openalex.org/I233745408 |
| authorships[4].institutions[0].ror | https://ror.org/03etyjw28 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I233745408 |
| authorships[4].institutions[0].country_code | CO |
| authorships[4].institutions[0].display_name | Pontificia Universidad Javeriana |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | S. Fiorentino |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[5].author.id | https://openalex.org/A5051050421 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8491-2952 |
| authorships[5].author.display_name | Alfonso Barreto |
| authorships[5].countries | CO |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I233745408 |
| authorships[5].affiliations[0].raw_affiliation_string | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[5].institutions[0].id | https://openalex.org/I233745408 |
| authorships[5].institutions[0].ror | https://ror.org/03etyjw28 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I233745408 |
| authorships[5].institutions[0].country_code | CO |
| authorships[5].institutions[0].display_name | Pontificia Universidad Javeriana |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | A. Barreto |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Cra 7 No 40-62, Bogotá, Colombia |
| authorships[6].author.id | https://openalex.org/A5017774989 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5426-3154 |
| authorships[6].author.display_name | Luz Marina Restrepo Múnera |
| authorships[6].countries | CO |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I35961687 |
| authorships[6].affiliations[0].raw_affiliation_string | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| authorships[6].institutions[0].id | https://openalex.org/I35961687 |
| authorships[6].institutions[0].ror | https://ror.org/03bp5hc83 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I35961687 |
| authorships[6].institutions[0].country_code | CO |
| authorships[6].institutions[0].display_name | Universidad de Antioquia |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | L. M. Restrepo |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Grupo Ingeniería de Tejidos y Terapías Celulares, Facultad de Medicina, Universidad de Antioquia, Carrera 51 A No 62-42, Medellín, Colombia |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10176 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9973999857902527 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2716 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Mesenchymal stem cell research |
| related_works | https://openalex.org/W4379052364, https://openalex.org/W2416795054, https://openalex.org/W2392126385, https://openalex.org/W1992848314, https://openalex.org/W3039146159, https://openalex.org/W2571013527, https://openalex.org/W2015667478, https://openalex.org/W1955721074, https://openalex.org/W4206781811, https://openalex.org/W3211551830 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1007/s00418-024-02265-1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S78725770 |
| best_oa_location.source.issn | 0948-6143, 1432-119X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0948-6143 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Histochemistry and Cell Biology |
| best_oa_location.source.host_organization | https://openalex.org/P4310319900 |
| best_oa_location.source.host_organization_name | Springer Science+Business Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Histochemistry and Cell Biology |
| best_oa_location.landing_page_url | https://doi.org/10.1007/s00418-024-02265-1 |
| primary_location.id | doi:10.1007/s00418-024-02265-1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S78725770 |
| primary_location.source.issn | 0948-6143, 1432-119X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0948-6143 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Histochemistry and Cell Biology |
| primary_location.source.host_organization | https://openalex.org/P4310319900 |
| primary_location.source.host_organization_name | Springer Science+Business Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s00418-024-02265-1.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Histochemistry and Cell Biology |
| primary_location.landing_page_url | https://doi.org/10.1007/s00418-024-02265-1 |
| publication_date | 2024-02-24 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4213197580, https://openalex.org/W3113218637, https://openalex.org/W2443870287, https://openalex.org/W2213048350, https://openalex.org/W3039202136, https://openalex.org/W2086914356, https://openalex.org/W4233074452, https://openalex.org/W1972739162, https://openalex.org/W2087881681, https://openalex.org/W1540414538, https://openalex.org/W2967763349, https://openalex.org/W3163963543, https://openalex.org/W1029875035, https://openalex.org/W3012408003, https://openalex.org/W1606209721, https://openalex.org/W2132834292, https://openalex.org/W2981240770, https://openalex.org/W2416839015, https://openalex.org/W2575770495, https://openalex.org/W2034269086, https://openalex.org/W2117692326, https://openalex.org/W3045994199, https://openalex.org/W2586419850, https://openalex.org/W1988864941, https://openalex.org/W2980813799, https://openalex.org/W4322754163, https://openalex.org/W2053233954, https://openalex.org/W2141815918, https://openalex.org/W2791605065, https://openalex.org/W2618499288, https://openalex.org/W2409057459, https://openalex.org/W3211554128, https://openalex.org/W2085013061, https://openalex.org/W3106058410, https://openalex.org/W2802956291, https://openalex.org/W2127787692, https://openalex.org/W2754913823, https://openalex.org/W1993943341, https://openalex.org/W2745124429, https://openalex.org/W2000511007, https://openalex.org/W3096597839, https://openalex.org/W2078758159, https://openalex.org/W2067437059, https://openalex.org/W3083900179, https://openalex.org/W2267633697, https://openalex.org/W2932428906, https://openalex.org/W2766696034, https://openalex.org/W2170124033, https://openalex.org/W2556204876, https://openalex.org/W2963590630, https://openalex.org/W3128646645, https://openalex.org/W2150047063, https://openalex.org/W2060494065, https://openalex.org/W2166473754, https://openalex.org/W2776514266, https://openalex.org/W2036932644, https://openalex.org/W2614088964, https://openalex.org/W2027706303, https://openalex.org/W1991701652 |
| referenced_works_count | 59 |
| abstract_inverted_index.a | 5, 51, 193 |
| abstract_inverted_index.In | 221 |
| abstract_inverted_index.It | 254 |
| abstract_inverted_index.We | 196 |
| abstract_inverted_index.as | 4, 50, 109, 118, 192, 216 |
| abstract_inverted_index.be | 302 |
| abstract_inverted_index.by | 244, 304 |
| abstract_inverted_index.in | 15, 101, 128, 168, 184, 205, 235, 238, 291, 315 |
| abstract_inverted_index.is | 2, 80 |
| abstract_inverted_index.it | 57 |
| abstract_inverted_index.of | 22, 76, 78, 86, 98, 156, 171, 179, 201, 241, 260, 272, 287, 299, 323 |
| abstract_inverted_index.on | 148, 159, 211, 276 |
| abstract_inverted_index.or | 28, 66, 269 |
| abstract_inverted_index.to | 123, 293 |
| abstract_inverted_index.we | 175 |
| abstract_inverted_index.For | 70 |
| abstract_inverted_index.MSC | 161, 188 |
| abstract_inverted_index.TME | 24, 194, 316 |
| abstract_inverted_index.The | 20, 154 |
| abstract_inverted_index.and | 13, 94, 111, 138, 145, 181, 219, 226, 251, 279 |
| abstract_inverted_index.can | 25, 63, 283, 301, 318 |
| abstract_inverted_index.did | 264 |
| abstract_inverted_index.for | 231 |
| abstract_inverted_index.has | 58, 163 |
| abstract_inverted_index.key | 233 |
| abstract_inverted_index.not | 265 |
| abstract_inverted_index.our | 308 |
| abstract_inverted_index.set | 85 |
| abstract_inverted_index.the | 16, 23, 40, 43, 73, 84, 90, 96, 126, 160, 169, 172, 177, 185, 199, 202, 239, 242, 258, 261, 267, 273, 285, 294, 297, 320 |
| abstract_inverted_index.via | 29 |
| abstract_inverted_index.was | 255 |
| abstract_inverted_index.MSCs | 79 |
| abstract_inverted_index.P2Et | 182 |
| abstract_inverted_index.TME, | 44 |
| abstract_inverted_index.TME. | 173 |
| abstract_inverted_index.also | 197 |
| abstract_inverted_index.been | 59, 116, 143, 164 |
| abstract_inverted_index.both | 64 |
| abstract_inverted_index.cell | 11, 190, 213 |
| abstract_inverted_index.even | 280 |
| abstract_inverted_index.fact | 295 |
| abstract_inverted_index.from | 134 |
| abstract_inverted_index.gene | 224 |
| abstract_inverted_index.have | 115, 142 |
| abstract_inverted_index.into | 89 |
| abstract_inverted_index.main | 74 |
| abstract_inverted_index.seen | 60 |
| abstract_inverted_index.some | 232 |
| abstract_inverted_index.stem | 46 |
| abstract_inverted_index.such | 108, 215 |
| abstract_inverted_index.that | 8, 61, 257, 296, 311 |
| abstract_inverted_index.they | 62, 105 |
| abstract_inverted_index.this | 281 |
| abstract_inverted_index.were | 229 |
| abstract_inverted_index.with | 53, 207 |
| abstract_inverted_index.Among | 39 |
| abstract_inverted_index.Here, | 174 |
| abstract_inverted_index.cells | 41, 47, 100 |
| abstract_inverted_index.chain | 248 |
| abstract_inverted_index.favor | 319 |
| abstract_inverted_index.found | 256 |
| abstract_inverted_index.hAMSC | 203, 223, 262, 312 |
| abstract_inverted_index.human | 186 |
| abstract_inverted_index.other | 99 |
| abstract_inverted_index.plant | 157 |
| abstract_inverted_index.since | 56 |
| abstract_inverted_index.their | 82, 129 |
| abstract_inverted_index.these | 208, 288 |
| abstract_inverted_index.thus, | 131 |
| abstract_inverted_index.tumor | 17, 68, 212, 236, 289 |
| abstract_inverted_index.types | 12 |
| abstract_inverted_index.where | 104 |
| abstract_inverted_index.(MSCs) | 48 |
| abstract_inverted_index.(P2Et) | 141 |
| abstract_inverted_index.(TME). | 19 |
| abstract_inverted_index.Cancer | 1 |
| abstract_inverted_index.affect | 266 |
| abstract_inverted_index.appear | 49 |
| abstract_inverted_index.cancer | 120, 277 |
| abstract_inverted_index.cells, | 278, 290 |
| abstract_inverted_index.effect | 155, 178 |
| abstract_inverted_index.etc.). | 38 |
| abstract_inverted_index.growth | 34 |
| abstract_inverted_index.model. | 195 |
| abstract_inverted_index.poorly | 165 |
| abstract_inverted_index.wounds | 110 |
| abstract_inverted_index.Natural | 113 |
| abstract_inverted_index.between | 125 |
| abstract_inverted_index.context | 170 |
| abstract_inverted_index.debated | 54 |
| abstract_inverted_index.disease | 7 |
| abstract_inverted_index.factors | 31, 234 |
| abstract_inverted_index.inhibit | 284 |
| abstract_inverted_index.involve | 9 |
| abstract_inverted_index.milieu, | 92 |
| abstract_inverted_index.models, | 150 |
| abstract_inverted_index.natural | 209, 274, 305, 324 |
| abstract_inverted_index.profile | 298 |
| abstract_inverted_index.promote | 65 |
| abstract_inverted_index.protein | 227 |
| abstract_inverted_index.reside, | 107 |
| abstract_inverted_index.reverse | 245 |
| abstract_inverted_index.showing | 151 |
| abstract_inverted_index.soluble | 30 |
| abstract_inverted_index.spinosa | 140 |
| abstract_inverted_index.studied | 117, 146, 176 |
| abstract_inverted_index.through | 81 |
| abstract_inverted_index.tumors. | 112 |
| abstract_inverted_index.various | 71 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Anamu-SC | 180 |
| abstract_inverted_index.Overall, | 307 |
| abstract_inverted_index.addition | 292 |
| abstract_inverted_index.alliacea | 136 |
| abstract_inverted_index.authors, | 72 |
| abstract_inverted_index.behavior | 97 |
| abstract_inverted_index.directly | 27 |
| abstract_inverted_index.extracts | 132, 158, 183, 243, 275 |
| abstract_inverted_index.factors, | 35 |
| abstract_inverted_index.findings | 309 |
| abstract_inverted_index.interact | 26 |
| abstract_inverted_index.modified | 303 |
| abstract_inverted_index.multiple | 10 |
| abstract_inverted_index.normally | 106 |
| abstract_inverted_index.obtained | 133 |
| abstract_inverted_index.possible | 119 |
| abstract_inverted_index.presence | 240, 259 |
| abstract_inverted_index.produced | 144 |
| abstract_inverted_index.products | 114 |
| abstract_inverted_index.reaction | 249 |
| abstract_inverted_index.results. | 153 |
| abstract_inverted_index.secreted | 88 |
| abstract_inverted_index.studied, | 166 |
| abstract_inverted_index.(RT-qPCR) | 250 |
| abstract_inverted_index.Petiveria | 135 |
| abstract_inverted_index.addition, | 222 |
| abstract_inverted_index.antitumor | 321 |
| abstract_inverted_index.appealing | 122 |
| abstract_inverted_index.attenuate | 67 |
| abstract_inverted_index.composing | 42 |
| abstract_inverted_index.cytotoxic | 268 |
| abstract_inverted_index.different | 149 |
| abstract_inverted_index.evaluated | 230 |
| abstract_inverted_index.hallmarks | 214 |
| abstract_inverted_index.influence | 200 |
| abstract_inverted_index.mechanism | 75 |
| abstract_inverted_index.migration | 286 |
| abstract_inverted_index.molecules | 87, 127, 300 |
| abstract_inverted_index.products, | 210 |
| abstract_inverted_index.products. | 306, 325 |
| abstract_inverted_index.promising | 152 |
| abstract_inverted_index.secretome | 162, 263, 282, 313 |
| abstract_inverted_index.synthesis | 228 |
| abstract_inverted_index.vesicles, | 37 |
| abstract_inverted_index.(Anamu-SC) | 137 |
| abstract_inverted_index.Multiplex, | 252 |
| abstract_inverted_index.activities | 271, 322 |
| abstract_inverted_index.components | 21 |
| abstract_inverted_index.especially | 167 |
| abstract_inverted_index.expression | 225 |
| abstract_inverted_index.migration. | 220 |
| abstract_inverted_index.phenotypes | 14 |
| abstract_inverted_index.polymerase | 247 |
| abstract_inverted_index.population | 52 |
| abstract_inverted_index.previously | 147 |
| abstract_inverted_index.properties | 55 |
| abstract_inverted_index.secretome, | 83, 204 |
| abstract_inverted_index.synergisms | 124 |
| abstract_inverted_index.understood | 3 |
| abstract_inverted_index.viability, | 217 |
| abstract_inverted_index.(cytokines, | 32 |
| abstract_inverted_index.Caesalpinia | 139 |
| abstract_inverted_index.chemokines, | 33 |
| abstract_inverted_index.combination | 206 |
| abstract_inverted_index.demonstrate | 310 |
| abstract_inverted_index.influencing | 95 |
| abstract_inverted_index.interaction | 77, 191 |
| abstract_inverted_index.mesenchymal | 45 |
| abstract_inverted_index.progression | 237 |
| abstract_inverted_index.recruiting, | 93 |
| abstract_inverted_index.treatments, | 121 |
| abstract_inverted_index.composition; | 130 |
| abstract_inverted_index.environments | 103 |
| abstract_inverted_index.inflammatory | 102 |
| abstract_inverted_index.interactions | 317 |
| abstract_inverted_index.investigated | 198 |
| abstract_inverted_index.progression. | 69 |
| abstract_inverted_index.extracellular | 36, 91 |
| abstract_inverted_index.participation | 314 |
| abstract_inverted_index.respectively. | 253 |
| abstract_inverted_index.clonogenicity, | 218 |
| abstract_inverted_index.multifactorial | 6 |
| abstract_inverted_index.(hAMSC)–tumor | 189 |
| abstract_inverted_index.adipose-derived | 187 |
| abstract_inverted_index.microenvironment | 18 |
| abstract_inverted_index.clonogenicity-reducing | 270 |
| abstract_inverted_index.transcription-quantitative | 246 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.77471067 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |