The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome Article Swipe
Hannah C. Kinney
,
Robin L. Haynes
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/jnen/nlz062
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/jnen/nlz062
The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined as the sudden and unexpected death of an infant <12 months of age that remains unexplained after a complete autopsy, death scene investigation, and review of the clinical history. The serotonin brainstem hypothesis has been a leading hypothesis for SIDS over the last 2 decades. Our laboratory has studied this hypothesis over time with a variety of tissue techniques, including tissue receptor autoradiography, high performance liquid chromatography, Western blot analysis, immunocytochemistry, and proteomics. The purpose of this article is to review the progress in our laboratory toward supporting this hypothesis. We conclude that an important subset of SIDS infants has serotonergic abnormalities resulting from a “core lesion” in the medullary reticular formation comprised of nuclei that contain serotonin neurons. This lesion could lead to a failure of protective brainstem responses to homeostatic challenges during sleep in a critical developmental period which cause sleep-related sudden death.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/jnen/nlz062
- OA Status
- green
- Cited By
- 65
- References
- 112
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2969763909
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2969763909Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/jnen/nlz062Digital Object Identifier
- Title
-
The Serotonin Brainstem Hypothesis for the Sudden Infant Death SyndromeWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-08-09Full publication date if available
- Authors
-
Hannah C. Kinney, Robin L. HaynesList of authors in order
- Landing page
-
https://doi.org/10.1093/jnen/nlz062Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/6934437Direct OA link when available
- Concepts
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Sudden infant death syndrome, Brainstem, Serotonergic, Autopsy, Medicine, Sudden death, Neuroscience, Infant mortality, Pathology, Serotonin, Pediatrics, Physiology, Biology, Internal medicine, Receptor, Population, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
65Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 14, 2023: 11, 2022: 9, 2021: 14Per-year citation counts (last 5 years)
- References (count)
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112Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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