The soft mechanical signature of glial scars in the central nervous system Article Swipe
Isabell P. Weber
,
Graham K. Sheridan
,
David E. Koser
,
Sara Soleman
,
Barbara Haenzi
,
Elizabeth J. Bradbury
,
James W. Fawcett
,
Kristian Franze
,
Emad Moeendarbary
·
YOU?
·
· 2017
· Open Access
·
YOU?
·
· 2017
· Open Access
·
Injury to the central nervous system (CNS) alters the molecular and cellular composition of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons. Mammalian glial scars supposedly form a chemical and mechanical barrier to neuronal regeneration. While tremendous effort has been devoted to identifying molecular characteristics of the scar, very little is known about its mechanical properties. Here we characterize spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using atomic force microscopy. In contrast to scars in other mammalian tissues, CNS tissue significantly softens after injury. Expression levels of glial intermediate filaments (GFAP, vimentin) and extracellular matrix components (laminin, collagen IV) correlate with tissue softening. As tissue stiffness is a regulator of neuronal growth, our results may help to understand why mammalian neurons do not regenerate after injury.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- http://hdl.handle.net/1721.1/110160
- OA Status
- green
- Cited By
- 1
- Related Works
- 4
- OpenAlex ID
- https://openalex.org/W2739246524
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W2739246524Canonical identifier for this work in OpenAlex
- Title
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The soft mechanical signature of glial scars in the central nervous systemWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-03-01Full publication date if available
- Authors
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Isabell P. Weber, Graham K. Sheridan, David E. Koser, Sara Soleman, Barbara Haenzi, Elizabeth J. Bradbury, James W. Fawcett, Kristian Franze, Emad MoeendarbaryList of authors in order
- Landing page
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https://hdl.handle.net/1721.1/110160Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://hdl.handle.net/1721.1/110160Direct OA link when available
- Concepts
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Signature (topology), Scars, Central nervous system, Nervous system, Peripheral nervous system, Neuroscience, Medicine, Anatomy, Pathology, Biology, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2021: 1Per-year citation counts (last 5 years)
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4Other works algorithmically related by OpenAlex
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