The Synthesis of Group 10 and 11 Metal Complexes of 3,6,9‐Trithia‐1‐(2,6)‐pyridinacyclodecaphane and Their Use in A³‐Coupling Reactions Article Swipe

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Chemistry Catalysis Toluene Metal Coupling reaction Group (periodic table) Crystal structure Medicinal chemistry Photochemistry Organic chemistry

Omer K. Rasheed , Carlo Bawn , David T. Davies , James Raftery , Íñigo J. Vitórica‐Yrezábal , Robin G. Pritchard , Huimin Zhou , Peter Quayle ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1002/ejoc.201701033 · OA: W2742705305

The reaction between 3,6,9‐trithia‐1(2,6)‐pyridinacyclodecaphane and representative group 10 and 11 metal salts [Cu(NO 3 ) 2 , NiCl 2 or Ag(CF 3 CO 2 )] afforded 1:1 complexes, which in the case of Cu II and Ag I were characterised by single‐crystal X‐ray crystallography. The catalytic activity of these complexes in A 3 ‐coupling reactions between aldehydes, terminal alkynes and amines was assessed in both protic (water) and aprotic (toluene) media. These A 3 ‐reactions prove to be more efficient, proceed with lower catalyst loadings and with faster reaction rates, when conducted in a focused microwave reactor as compared to the same reactions promoted by standard, thermal, modes of activation.