American Journal of Physiology-Heart and Circulatory Physiology • Vol 329 • No 1
The two-pore K<sup>+</sup> channel TREK-1 regulates pressure overload-induced cardiac remodeling
May 2025 • C M Johnson, Drew Nassal, Alexander J. Winkle, Benjamin Buck, Xianyao Xu, Xiaoping Wan, Mei Han, Simon Lococo, Nicholas Leahy, Shivangi Mohta, Rebecc…
A major finding of this study is the involvement of the background K + channel TREK-1 in modulating STAT3 activation, profibrotic gene expression, and fibrosis with implications for the cardiac remodeling response to chronic pressure overload.