The Use of Tenofovir Disoproxil Fumarate in the Management of eAg-Negative Chronic Hepatitis B Infection Article Swipe
Nishita Jagarlamudi
,
Melissa Reyes
,
Scott Fung
,
Florence Wong
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13071864
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13071864
Background/Objectives: Currently, there are insufficient data to recommend the treatment of patients with hepatitis B e antigen (HBeAg)-negative chronic infection who have normal ALT and low HBV DNA, since the prognosis is generally regarded as favorable. The aim of this pilot study was to determine whether the use of tenofovir disoproxil fumarate (TDF) 300 mg/day for 3 years was able to achieve functional cure (HBsAg loss) and HBsAg seroconversion in HBeAb-positive individuals. Methods: Fifty patients not on antiviral therapy (40% men, mean age 48.9 ± 10.9 years, 84% Asians) with minimal fibrosis were enrolled. Results: TDF reduced HBV DNA significantly to undetectable levels after 6 months. Overall, 48.3% of inactive carriers (baseline HBV DNA < 2000 IU/mL) remained HBV DNA negative 6 months after treatment withdrawal, which was significantly higher than the 5.6% in those who were not inactive carriers (baseline HBV DNA ≥ 2000 IU/mL) (p = 0.003). The HBsAg levels did not drop throughout the study period with no difference between inactive carriers versus those who were not. Five inactive carriers achieved functional cure, but none of these were amongst those who were not inactive carriers. No renal dysfunction or ALT flare on treatment withdrawal was observed. Conclusions: TDF could potentially be used to induce functional cure in patients who are inactive carriers with normal ALT, low HBV DNA and without advanced fibrosis.
Related Topics
Concepts
Medicine
HBeAg
HBsAg
Seroconversion
Internal medicine
Gastroenterology
Entecavir
Hepatitis B virus
Hepatitis B
Tenofovir
Immunology
Virus
Lamivudine
Human immunodeficiency virus (HIV)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm13071864
- https://www.mdpi.com/2077-0383/13/7/1864/pdf?version=1711266697
- OA Status
- gold
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393142796
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393142796Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm13071864Digital Object Identifier
- Title
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The Use of Tenofovir Disoproxil Fumarate in the Management of eAg-Negative Chronic Hepatitis B InfectionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-24Full publication date if available
- Authors
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Nishita Jagarlamudi, Melissa Reyes, Scott Fung, Florence WongList of authors in order
- Landing page
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https://doi.org/10.3390/jcm13071864Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/13/7/1864/pdf?version=1711266697Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/13/7/1864/pdf?version=1711266697Direct OA link when available
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Medicine, HBeAg, HBsAg, Seroconversion, Internal medicine, Gastroenterology, Entecavir, Hepatitis B virus, Hepatitis B, Tenofovir, Immunology, Virus, Lamivudine, Human immunodeficiency virus (HIV)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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37Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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