The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk Patients Article Swipe
Yafei Wu
,
Yuanyuan Chen
,
Lili Wei
,
Zhanling Ding
,
Shengfa Zhao
,
Shengxian Bao
,
Jiali Tang
,
Hang Li
,
Junjie Liu
,
shangyong zhu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3352840/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3352840/v1
Background We found that the incidence rate of hepatocellular carcinoma (HCC) has increased significantly in non-cirrhotic patients, with HCC being frequently overlooked or misdiagnosed. Contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) is known to have a high diagnostic value in high-risk HCC patients. Therefore, we aimed to compare the diagnostic value of CEUS LI-RADS for HCC between low- (LR) and high-risk (HR) patients, to confirm its value in LR patients. In addition, since CEUS LR-4 and LR-M categories contain a relatively high proportion of HCC, and serum alpha-fetoprotein (AFP) is the most used HCC biomarker, and the clinically valid, we attempted to further improve the early diagnostic value of CEUS LI-RADS for HCC in the LR and HR patients by combining CEUS LR-4 and LR-M categories with AFP. Methods We enrolled 189 HCC patients with LR and HR in a retrospective study. All lesions were confirmed histopathologically. Diagnostic performance of CEUS LI-RADS for HCC in these two patients was compared. In addition, we analyzed the value of CEUS LI-RADS as a valid method of establishing the early diagnosis for HCC in LR and HR patients by combining LR-4 and LR-M category with AFP. Results Through comparative analysis, we found that, due to the high proportion of HCC in CEUS LR-4 and LR-M categories in our cases, the specificity of CEUS LR-5 category for HCC in the HR group was 78.4%, whereas in the LR group it was 94.2%. Meanwhile, the sensitivity (63.2% vs 63.0%) and positive predictive value (PPV) (75.0% vs 88.7%) did not differ between the LR and HR groups (P = 0.299, P = 0.965). It is noteworthy that when we combined CEUS LR-4 and LR-M categories with AFP significantly improved the sensitivity and PPV by 21.0%, 5.0% in the LR group, and by 16.0%, 2.1% in the HR group (P = 0.836, P = 0.836, respectively). Conclusions The CEUS LR-5 category has real clinical value in diagnosing HCC in both LR and HR patients. The early diagnostic value of CEUS LI-RADS category for HCC patients was further increased when CEUS LR-4 and LR-M categories was combined with elevated AFP.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3352840/v1
- https://www.researchsquare.com/article/rs-3352840/latest.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386880501
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386880501Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3352840/v1Digital Object Identifier
- Title
-
The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk PatientsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-09-21Full publication date if available
- Authors
-
Yafei Wu, Yuanyuan Chen, Lili Wei, Zhanling Ding, Shengfa Zhao, Shengxian Bao, Jiali Tang, Hang Li, Junjie Liu, shangyong zhuList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-3352840/v1Publisher landing page
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https://www.researchsquare.com/article/rs-3352840/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3352840/latest.pdfDirect OA link when available
- Concepts
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Medicine, Hepatocellular carcinoma, Contrast-enhanced ultrasound, Radiology, Ultrasound, Internal medicine, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 2Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.88.7%) | 255 |
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