The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation Article Swipe
Cyrielle Bouchez
,
Noureddine Hammad
,
Sylvain Cuvellier
,
Stéphane Ransac
,
Michel Rigoulet
,
Anne Devin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2020.01333
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2020.01333
O. Warburg conducted one of the first studies on tumor energy metabolism. His early discoveries pointed out that cancer cells display a decreased respiration and an increased glycolysis proportional to the increase in their growth rate, suggesting that they mainly depend on fermentative metabolism for ATP generation. Warburg's results and hypothesis generated controversies that are persistent to this day. It is thus of great importance to understand the mechanisms by which cancer cells can reversibly regulate the two pathways of their energy metabolism as well as the functioning of this metabolism in cell proliferation. Here, we made use of yeast as a model to study the Warburg effect and its eventual function in allowing an increased ATP synthesis to support cell proliferation. The role of oxidative phosphorylation repression in this effect was investigated. We show that yeast is a good model to study the Warburg effect, where all parameters and their modulation in the presence of glucose can be reconstituted. Moreover, we show that in this model, mitochondria are not dysfunctional, but that there are fewer mitochondria respiratory chain units per cell. Identification of the molecular mechanisms involved in this process allowed us to dissociate the parameters involved in the Warburg effect and show that oxidative phosphorylation repression is not mandatory to promote cell growth. Last but not least, we were able to show that neither cellular ATP synthesis flux nor glucose consumption flux controls cellular growth rate.
Related Topics
Concepts
Warburg effect
Yeast
Cell biology
Psychological repression
Cell growth
Cell metabolism
Mitochondrion
Metabolism
Cell
Saccharomyces cerevisiae
Chemistry
Biology
Cancer research
Glycolysis
Biochemistry
Gene
Gene expression
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2020.01333
- OA Status
- gold
- Cited By
- 21
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3048469064
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3048469064Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2020.01333Digital Object Identifier
- Title
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The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell ProliferationWork title
- Type
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articleOpenAlex work type
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-08-19Full publication date if available
- Authors
-
Cyrielle Bouchez, Noureddine Hammad, Sylvain Cuvellier, Stéphane Ransac, Michel Rigoulet, Anne DevinList of authors in order
- Landing page
-
https://doi.org/10.3389/fonc.2020.01333Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fonc.2020.01333Direct OA link when available
- Concepts
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Warburg effect, Yeast, Cell biology, Psychological repression, Cell growth, Cell metabolism, Mitochondrion, Metabolism, Cell, Saccharomyces cerevisiae, Chemistry, Biology, Cancer research, Glycolysis, Biochemistry, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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21Total citation count in OpenAlex
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2025: 4, 2024: 3, 2023: 2, 2022: 7, 2021: 5Per-year citation counts (last 5 years)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.functioning | 87 |
| abstract_inverted_index.generation. | 46 |
| abstract_inverted_index.metabolism. | 11 |
| abstract_inverted_index.respiration | 23 |
| abstract_inverted_index.respiratory | 177 |
| abstract_inverted_index.fermentative | 42 |
| abstract_inverted_index.mitochondria | 167, 176 |
| abstract_inverted_index.proportional | 28 |
| abstract_inverted_index.controversies | 52 |
| abstract_inverted_index.investigated. | 132 |
| abstract_inverted_index.Identification | 182 |
| abstract_inverted_index.dysfunctional, | 170 |
| abstract_inverted_index.proliferation. | 93, 121 |
| abstract_inverted_index.reconstituted. | 159 |
| abstract_inverted_index.phosphorylation | 126, 206 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5037180539 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I1294671590, https://openalex.org/I4210140961 |
| citation_normalized_percentile.value | 0.79242601 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |