Therapeutic and diagnostic implications of exosomes as natural nanoparticles: a new paradigm in brain cancer disease management Article Swipe
Shanid Mohiyuddin
,
Pankaj Dipankar
,
Belfin Robinson
,
Andrew Jeyabose
,
J. Karthikeyan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2025.1599392
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2025.1599392
The clinical translation of safe and effective therapeutic methods for brain cancer treatment is a major challenge that persists in modern medicine. The insufficient drug delivery into the regime of the affected brain tissue due to blood–brain barrier (BBB) restriction leads to a poor prognosis of the disease. However, an alternative strategy using biomaterials like exosomes can offer advancements in the treatment of brain cancer. Exosomes are a type of extracellular microvesicle with a diameter of 30–100 nm, principally functioning as intercellular mediators in the cell signaling process. Due to their biological origin, exosomes demonstrate a significant ability to cross the BBB and possess enhanced biocompatibility, high drug-loading capacity, and low immunogenicity. With the innate property of biomolecule delivery, exosomes also offer enhanced cellular uptake, rendering them exceptional in drug delivery systems. Herein, we focus on the anticancer and diagnostic applications of exosomes for brain cancer therapeutics. The enhancement of the physico-chemical properties of various cell-derived exosomes can be effectively used as a prime drug delivery agent in most treatment strategies. The biphasic and fast drug release in acidic pH of the tumor microenvironment by exosome-mediated drug delivery system contributes to passive targeting, which is often considered advantageous over other drug delivery platforms. These characteristic features are likely to enhance the therapeutic potential and efficacy of the treatment. The exosome loaded with the drug acts as an efficient biomaterial to surpass the BBB, followed by efficient cellular uptake, leading to cytotoxicity in glioblastoma cells. In this review, we summarize the recent updates in theranostic and prognostic strategies using exosomes as a mediator and their prevalence in biomedical applications, with a focus on brain cancer diseases.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2025.1599392
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1599392/pdf
- OA Status
- gold
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412506785
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Raw OpenAlex JSON
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https://openalex.org/W4412506785Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmed.2025.1599392Digital Object Identifier
- Title
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Therapeutic and diagnostic implications of exosomes as natural nanoparticles: a new paradigm in brain cancer disease managementWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-21Full publication date if available
- Authors
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Shanid Mohiyuddin, Pankaj Dipankar, Belfin Robinson, Andrew Jeyabose, J. KarthikeyanList of authors in order
- Landing page
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https://doi.org/10.3389/fmed.2025.1599392Publisher landing page
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https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1599392/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1599392/pdfDirect OA link when available
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Microvesicles, Disease, Medicine, Brain cancer, Cancer, Intensive care medicine, Pathology, Internal medicine, microRNA, Biology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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