Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems Article Swipe
Ana Clara Barbosa Antonelli
,
Lucas Silva Rodrigues
,
Maria Clara Moura Pinheiro
,
Sylvia Barbosa Pinhate
,
Marcelo de Macedo Brigido
,
Andréa Queiróz Maranhão
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adtp.202500422
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adtp.202500422
Mosquito‐borne orthoflaviviruses such as Zika virus (ZIKV), dengue (DENV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis virus (JEV) are major public health concerns worldwide due to their epidemic potential, immune evasion mechanisms, and the absence of specific antiviral treatments. While vaccines exist for JEV, DENV, and Yellow Fever, their use is limited by safety concerns in vulnerable populations. In this context, monoclonal antibodies (mAbs) gain attention as potent and specific therapeutic tools. A central focus of recent research is the orthoflavivirus envelope (E) protein, particularly the fusion loop (FL), which is a highly conserved region within domain II that plays a critical role in viral membrane fusion and entry. The FL is a structural conservation across orthoflavivirus species, making it a target for the development of neutralizing antibodies (NAbs). This review highlights the key mechanisms of mAb‐mediated neutralization, with a focus on FL‐targeting strategies, and discusses how rational antigen design and antibody engineering are overcoming challenges related to epitope accessibility and antibody‐dependent enhancement. Strategies for antibody discovery, such as phage display and Fc engineering are explored. Finally, mRNA‐based platforms for in vivo antibody expression, offering an approach to rapid antibody expression to combat orthoflavivirus infections are discussed.
Related Topics
Concepts
Virology
Antibody
Dengue virus
Zika virus
Antibody-dependent enhancement
Monoclonal antibody
Immunology
Dengue fever
Epitope
Medicine
Immune system
Virus
Biology
Viral envelope
Flavivirus
Antigen
Lipid bilayer fusion
Dengue vaccine
Viral hemorrhagic fever
Ebola virus
Japanese encephalitis
Chimeric antigen receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adtp.202500422
- OA Status
- hybrid
- References
- 227
- OpenAlex ID
- https://openalex.org/W7106331839
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106331839Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adtp.202500422Digital Object Identifier
- Title
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Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery SystemsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-20Full publication date if available
- Authors
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Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brigido, Andréa Queiróz MaranhãoList of authors in order
- Landing page
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https://doi.org/10.1002/adtp.202500422Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/adtp.202500422Direct OA link when available
- Concepts
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Virology, Antibody, Dengue virus, Zika virus, Antibody-dependent enhancement, Monoclonal antibody, Immunology, Dengue fever, Epitope, Medicine, Immune system, Virus, Biology, Viral envelope, Flavivirus, Antigen, Lipid bilayer fusion, Dengue vaccine, Viral hemorrhagic fever, Ebola virus, Japanese encephalitis, Chimeric antigen receptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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227Number of works referenced by this work
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