Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats Article Swipe
Firoz Akhter
,
Sahir Sultan Alvi
,
Parvej Ahmad
,
Danish Iqbal
,
Bader Alshehri
,
M. Salman Khan
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15419/bmrat.v6i7.556
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15419/bmrat.v6i7.556
Introduction: We have previously demonstrated that sequentially extracted methanolic fractions of Boerhaavia diffusa (Linn.) showed marked antioxidant, antidiabetic and oxidative-DNA damage protective properties in vitro. The present study was undertaken to evaluate the beneficial effects of B.diffusa (Linn.) methanolic root extract and its partially purified bioactive fraction on streptozotocin (STZ)-induced hyperglycemia and hyperlipidemia in rats. Methods: The diabetic rats were treated for fourteen weeks either with methanolic extract of B. diffusa root (D-MT1, D-MT2, and D-MT3 : doses of 50, 150, and 300 mg/rat/day, respectively), partially isolated bioactive fraction (DBT: 0.5 mg/rat/day), or glibenclamide (D-GT: 0.5 mg/rat/day). Results: The level of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) were significantly alleviated in D-MT- and D-BT treated groups after fourteen weeks of administration. Moreover, plasma lipid profile, free fatty acids (FFAs), phospholipids (PLs), HMG-CoA reductase (HMG-R) activity, conjugated diene (CD), lipid hydroperoxide (LOOH), and malondialdehyde (MDA) were also markedly ameliorate d in all treatment groups. In addition, the activity of antioxidant enzymes, e.g., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (Gred), and glutathione-S-transferase (GST), were also significantly restored by D-MT — and D-BT — treated groups. Furthermore, histologically, all the unseemly features of nephropathy were extensively regressed and normalized by the administration of B. diffusa and its bioactive fraction. Conclusions: Our results demonstrate a strong antidiabetic and hypolipidemic impact of B. diffusa extract an ideal alternative therapeutic agent in the prevention and treatment of diabetes as well as diabetes-linked hyperlipidemia.
Related Topics
Concepts
Oxidative stress
Antioxidant
Streptozotocin
Hyperlipidemia
Glutathione peroxidase
Glibenclamide
Glutathione
Pharmacology
Malondialdehyde
Glutathione reductase
Superoxide dismutase
Diabetes mellitus
Traditional medicine
Chemistry
Lipid profile
Catalase
Medicine
Biochemistry
Endocrinology
Enzyme
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15419/bmrat.v6i7.556
- http://www.bmrat.org/index.php/BMRAT/article/download/556/1117
- OA Status
- diamond
- Cited By
- 39
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2962076438
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2962076438Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.15419/bmrat.v6i7.556Digital Object Identifier
- Title
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Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in ratsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-07-13Full publication date if available
- Authors
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Firoz Akhter, Sahir Sultan Alvi, Parvej Ahmad, Danish Iqbal, Bader Alshehri, M. Salman KhanList of authors in order
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https://doi.org/10.15419/bmrat.v6i7.556Publisher landing page
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https://www.bmrat.org/index.php/BMRAT/article/download/556/1117Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.bmrat.org/index.php/BMRAT/article/download/556/1117Direct OA link when available
- Concepts
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Oxidative stress, Antioxidant, Streptozotocin, Hyperlipidemia, Glutathione peroxidase, Glibenclamide, Glutathione, Pharmacology, Malondialdehyde, Glutathione reductase, Superoxide dismutase, Diabetes mellitus, Traditional medicine, Chemistry, Lipid profile, Catalase, Medicine, Biochemistry, Endocrinology, EnzymeTop concepts (fields/topics) attached by OpenAlex
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39Total citation count in OpenAlex
- Citations by year (recent)
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2024: 4, 2023: 15, 2022: 6, 2021: 10, 2020: 4Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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