Therapeutic potential of flavonols in the treatment of JCPyV Article Swipe
Evan MacLure
,
Kaitlin Garabian
,
Bethany A. O’Hara
,
Wenqing Yuan
,
Jacob Kaiserman
,
Avraham S. Lukacher
,
Sheila A. Haley
,
Walter J. Atwood
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.01527-25
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.01527-25
JC polyomavirus (JCPyV) is a double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease with a high rate of morbidity and mortality. There are limited treatment options for patients diagnosed with PML, and most involve reconstitution of immunological functions. In this paper, we show that flavonols, specifically quercetin, myricetin, and fisetin, significantly reduce JCPyV infection in human glial cells. We further show that quercetin and fisetin can suppress viral spread in an already established infection, suggesting therapeutic viability of these drugs as antivirals. Additional research is required to determine the mechanism of action of flavonols in inhibiting JCPyV infection and to investigate whether these compounds have the potential to cross the blood-brain barrier in significant amounts to inhibit the virus in the brain parenchyma. IMPORTANCE The human polyomavirus, JC polyomavirus (JCPyV), causes significant morbidity and mortality in immunosuppressed or immunomodulated patients. There are no approved antivirals to treat JCPyV-induced disease. Flavonols are naturally occurring polyphenolic compounds that are known to antagonize pathways involved in JCPyV infection. Several flavonols were found to inhibit initial JCPyV infection and viral spread in a glial cell line and in normal human glial cells. These represent a promising new treatment paradigm for patients at risk of suffering from JCPyV-induced disease.
Related Topics
Concepts
Flavonols
Fisetin
Progressive multifocal leukoencephalopathy
Myricetin
JC virus
Demyelinating disease
Biology
Disease
Quercetin
Virology
Virus
Medicine
Multiple sclerosis
Immunology
Internal medicine
Kaempferol
Antioxidant
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/spectrum.01527-25
- OA Status
- gold
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413375152
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413375152Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1128/spectrum.01527-25Digital Object Identifier
- Title
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Therapeutic potential of flavonols in the treatment of JCPyVWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-08-21Full publication date if available
- Authors
-
Evan MacLure, Kaitlin Garabian, Bethany A. O’Hara, Wenqing Yuan, Jacob Kaiserman, Avraham S. Lukacher, Sheila A. Haley, Walter J. AtwoodList of authors in order
- Landing page
-
https://doi.org/10.1128/spectrum.01527-25Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/spectrum.01527-25Direct OA link when available
- Concepts
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Flavonols, Fisetin, Progressive multifocal leukoencephalopathy, Myricetin, JC virus, Demyelinating disease, Biology, Disease, Quercetin, Virology, Virus, Medicine, Multiple sclerosis, Immunology, Internal medicine, Kaempferol, Antioxidant, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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83Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.with | 18, 34 |
| abstract_inverted_index.JCPyV | 57, 101, 168, 177 |
| abstract_inverted_index.There | 26, 145 |
| abstract_inverted_index.These | 193 |
| abstract_inverted_index.brain | 126 |
| abstract_inverted_index.cross | 113 |
| abstract_inverted_index.drugs | 84 |
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| abstract_inverted_index.glial | 61, 184, 191 |
| abstract_inverted_index.human | 60, 130, 190 |
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| abstract_inverted_index.these | 83, 107 |
| abstract_inverted_index.treat | 151 |
| abstract_inverted_index.viral | 72, 180 |
| abstract_inverted_index.virus | 8, 123 |
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| abstract_inverted_index.causes | 10, 135 |
| abstract_inverted_index.cells. | 62, 192 |
| abstract_inverted_index.normal | 189 |
| abstract_inverted_index.paper, | 45 |
| abstract_inverted_index.reduce | 56 |
| abstract_inverted_index.spread | 73, 181 |
| abstract_inverted_index.(JCPyV) | 3 |
| abstract_inverted_index.Several | 170 |
| abstract_inverted_index.already | 76 |
| abstract_inverted_index.amounts | 119 |
| abstract_inverted_index.barrier | 116 |
| abstract_inverted_index.disease | 17 |
| abstract_inverted_index.fisetin | 69 |
| abstract_inverted_index.further | 64 |
| abstract_inverted_index.inhibit | 121, 175 |
| abstract_inverted_index.initial | 176 |
| abstract_inverted_index.involve | 38 |
| abstract_inverted_index.limited | 28 |
| abstract_inverted_index.options | 30 |
| abstract_inverted_index.whether | 106 |
| abstract_inverted_index.(JCPyV), | 134 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.approved | 148 |
| abstract_inverted_index.disease. | 153, 208 |
| abstract_inverted_index.fisetin, | 54 |
| abstract_inverted_index.involved | 166 |
| abstract_inverted_index.paradigm | 199 |
| abstract_inverted_index.pathways | 165 |
| abstract_inverted_index.patients | 32, 201 |
| abstract_inverted_index.required | 90 |
| abstract_inverted_index.research | 88 |
| abstract_inverted_index.suppress | 71 |
| abstract_inverted_index.Flavonols | 154 |
| abstract_inverted_index.compounds | 108, 159 |
| abstract_inverted_index.determine | 92 |
| abstract_inverted_index.diagnosed | 33 |
| abstract_inverted_index.flavonols | 98, 171 |
| abstract_inverted_index.infection | 58, 102, 178 |
| abstract_inverted_index.mechanism | 94 |
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| abstract_inverted_index.mortality | 139 |
| abstract_inverted_index.naturally | 156 |
| abstract_inverted_index.occurring | 157 |
| abstract_inverted_index.patients. | 144 |
| abstract_inverted_index.potential | 111 |
| abstract_inverted_index.promising | 196 |
| abstract_inverted_index.quercetin | 67 |
| abstract_inverted_index.represent | 194 |
| abstract_inverted_index.suffering | 205 |
| abstract_inverted_index.treatment | 29, 198 |
| abstract_inverted_index.viability | 81 |
| abstract_inverted_index.Additional | 87 |
| abstract_inverted_index.IMPORTANCE | 128 |
| abstract_inverted_index.antagonize | 164 |
| abstract_inverted_index.antivirals | 149 |
| abstract_inverted_index.flavonols, | 49 |
| abstract_inverted_index.functions. | 42 |
| abstract_inverted_index.infection, | 78 |
| abstract_inverted_index.infection. | 169 |
| abstract_inverted_index.inhibiting | 100 |
| abstract_inverted_index.mortality. | 25 |
| abstract_inverted_index.multifocal | 12 |
| abstract_inverted_index.myricetin, | 52 |
| abstract_inverted_index.quercetin, | 51 |
| abstract_inverted_index.suggesting | 79 |
| abstract_inverted_index.antivirals. | 86 |
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| abstract_inverted_index.investigate | 105 |
| abstract_inverted_index.parenchyma. | 127 |
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| abstract_inverted_index.polyphenolic | 158 |
| abstract_inverted_index.specifically | 50 |
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| abstract_inverted_index.immunological | 41 |
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| abstract_inverted_index.double-stranded | 6 |
| abstract_inverted_index.immunomodulated | 143 |
| abstract_inverted_index.immunosuppressed | 141 |
| abstract_inverted_index.leukoencephalopathy | 13 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| citation_normalized_percentile.value | 0.48111231 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |