Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome Article Swipe
Ling Zuo
,
Yang Hai
,
Ruoyu Zhang
,
Biao Zuo
,
Jiayu Tian
,
Pan Li
,
Xiumei Ke
,
Meng Wang
,
Li Ren
,
Xue-Zhi Li
,
Xuekuan Huang
,
Jianwei Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejphar.2023.175825
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejphar.2023.175825
Polycystic ovary syndrome (PCOS) is characterized by reproductive, endocrine, and metabolic disorders. Icariin has been shown to regulate endocrine and metabolic imbalances. This study aimed to determine the therapeutic effect and pharmacological mechanism of icariin in PCOS rats. Rats were fed a high-fat diet and gavaged with letrozole to induce PCOS. Thirty-six female rats were randomly divided into four groups: control, model, low-dose, and high-dose icariin. After 30 days of treatment, we evaluated the therapeutic effects on weight and diet, sex hormone levels, ovarian morphology, estrous cycle, inflammatory factors, and indicators of glucolipid metabolism. Combined with the ovarian transcriptome, we verified the key markers of apoptosis and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway by RT-qPCR for mRNA level, western blot, and immunohistochemistry for protein expression. Icariin significantly improved ovarian function and reproductive endocrine disorders by regulating sex hormones, restoring the estrous cycle, and reducing ovarian morphological damage in PCOS rats. Icariin-treated rats had lower weight gain and reduced triglycerides, fasting insulin, HOMA-IR, TNF-α, and interleukin-6 with higher high-density lipoprotein cholesterol levels than PCOS rats. TUNEL staining showed icariin improved apoptosis in the ovaries. This was supported by an increase in Bcl2 and a decrease in Bad and Bax. Icariin decreased the ratios of p-JAK2/JAK2, p-STAT1/STAT1, p-STAT3/STAT3, and p-STAT5a/STAT5a, decreased IL-6, gp130 expression, and increased cytokine-inducible SH2-containing protein (CISH) and suppressor of cytokine signaling 1 (SOCS1) expression. The pharmacological mechanism may be related to the reduction in ovarian apoptosis and inhibition of the IL-6/gp130/JAK2/STATs pathway.
Related Topics
Concepts
Endocrinology
Internal medicine
Polycystic ovary
Biology
Estrous cycle
STAT3
Adiponectin
Insulin
Medicine
Apoptosis
Insulin resistance
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ejphar.2023.175825
- OA Status
- hybrid
- Cited By
- 10
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379055932
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379055932Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ejphar.2023.175825Digital Object Identifier
- Title
-
Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndromeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-06-01Full publication date if available
- Authors
-
Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xue-Zhi Li, Xuekuan Huang, Jianwei WangList of authors in order
- Landing page
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https://doi.org/10.1016/j.ejphar.2023.175825Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.ejphar.2023.175825Direct OA link when available
- Concepts
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Endocrinology, Internal medicine, Polycystic ovary, Biology, Estrous cycle, STAT3, Adiponectin, Insulin, Medicine, Apoptosis, Insulin resistance, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.hormones, | 142 |
| abstract_inverted_index.increased | 218 |
| abstract_inverted_index.letrozole | 47 |
| abstract_inverted_index.low-dose, | 62 |
| abstract_inverted_index.mechanism | 32, 233 |
| abstract_inverted_index.metabolic | 10, 20 |
| abstract_inverted_index.reduction | 239 |
| abstract_inverted_index.restoring | 143 |
| abstract_inverted_index.signaling | 116, 227 |
| abstract_inverted_index.supported | 190 |
| abstract_inverted_index.(JAK/STAT) | 115 |
| abstract_inverted_index.Polycystic | 0 |
| abstract_inverted_index.Thirty-six | 51 |
| abstract_inverted_index.disorders. | 11 |
| abstract_inverted_index.endocrine, | 8 |
| abstract_inverted_index.glucolipid | 92 |
| abstract_inverted_index.indicators | 90 |
| abstract_inverted_index.inhibition | 244 |
| abstract_inverted_index.regulating | 140 |
| abstract_inverted_index.suppressor | 224 |
| abstract_inverted_index.transducer | 110 |
| abstract_inverted_index.treatment, | 70 |
| abstract_inverted_index.cholesterol | 174 |
| abstract_inverted_index.expression, | 216 |
| abstract_inverted_index.expression. | 129, 230 |
| abstract_inverted_index.imbalances. | 21 |
| abstract_inverted_index.lipoprotein | 173 |
| abstract_inverted_index.metabolism. | 93 |
| abstract_inverted_index.morphology, | 84 |
| abstract_inverted_index.therapeutic | 28, 74 |
| abstract_inverted_index.high-density | 172 |
| abstract_inverted_index.inflammatory | 87 |
| abstract_inverted_index.p-JAK2/JAK2, | 208 |
| abstract_inverted_index.reproductive | 136 |
| abstract_inverted_index.characterized | 5 |
| abstract_inverted_index.interleukin-6 | 169 |
| abstract_inverted_index.kinase/signal | 109 |
| abstract_inverted_index.morphological | 150 |
| abstract_inverted_index.reproductive, | 7 |
| abstract_inverted_index.significantly | 131 |
| abstract_inverted_index.transcription | 114 |
| abstract_inverted_index.SH2-containing | 220 |
| abstract_inverted_index.p-STAT1/STAT1, | 209 |
| abstract_inverted_index.p-STAT3/STAT3, | 210 |
| abstract_inverted_index.transcriptome, | 98 |
| abstract_inverted_index.triglycerides, | 163 |
| abstract_inverted_index.Icariin-treated | 155 |
| abstract_inverted_index.pharmacological | 31, 232 |
| abstract_inverted_index.p-STAT5a/STAT5a, | 212 |
| abstract_inverted_index.cytokine-inducible | 219 |
| abstract_inverted_index.immunohistochemistry | 126 |
| abstract_inverted_index.IL-6/gp130/JAK2/STATs | 247 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5101764752, https://openalex.org/A5100424784 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I87780372 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91108827 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |