Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1111/jcmm.17635
Centella asiatica is an ethnomedicinal herbaceous species that grows abundantly in tropical and sub‐tropical regions of China, India, South‐Eastern Asia and Africa. It is a popular nutraceutical that is employed in various forms of clinical and cosmetic treatments. C. asiatica extracts are reported widely in Ayurvedic and Chinese traditional medicine to boost memory, prevent cognitive deficits and improve brain functions. The major bioactive constituents of C. asiatica are the pentacyclic triterpenoid glycosides, asiaticoside and madecassoside, and their corresponding aglycones, asiatic acid and madecassic acid. Asiaticoside and madecassoside have been identified as the marker compounds of C. asiatica in the Chinese Pharmacopoeia and these triterpene compounds offer a wide range of pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti‐inflammatory, anti‐oxidant, anti‐allergic, anti‐depressant, anxiolytic, antifibrotic, antibacterial, anti‐arthritic, anti‐tumour and immunomodulatory activities. Asiaticoside and madecassoside are also used extensively in treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis and scleroderma. Besides medicinal applications, these phytocompounds are considered cosmetically beneficial for their role in anti‐ageing, skin hydration, collagen synthesis, UV protection and curing scars. Existing reports and experimental studies on these compounds between 2005 and 2022 have been selectively reviewed in this article to provide a comprehensive overview of the numerous therapeutic advantages of asiaticoside and madecassoside and their potential roles in the medical future.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/jcmm.17635
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.17635
- OA Status
- gold
- Cited By
- 142
- References
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- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4319657069Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jcmm.17635Digital Object Identifier
- Title
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Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A reviewWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-08Full publication date if available
- Authors
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Shinjini Bandopadhyay, Sujata Mandal, Mimosa Ghorai, Niraj Kumar Jha, Manoj Kumar, Radha CHAUHAN, Arabinda Ghosh, Jarosław Proćków, Jose Manuel Pérez de la Lastra, Abhijit DeyList of authors in order
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https://doi.org/10.1111/jcmm.17635Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.17635Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.17635Direct OA link when available
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Centella, Traditional medicine, Medicine, Pharmacology, Traditional Chinese medicine, Anti-inflammatory, Ayurvedic medicine, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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142Total citation count in OpenAlex
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2025: 73, 2024: 53, 2023: 16Per-year citation counts (last 5 years)
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155Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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