Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice Article Swipe
Samuel McFadden
,
Mackenzie R. Peck
,
Lindsey N. Sime
,
MaKayla F. Cox
,
Erol D. Ikiz
,
Caleigh A. Findley
,
Kathleen Quinn
,
Yimin Fang
,
Andrzej Bartke
,
Erin R. Hascup
,
Kevin N. Hascup
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.26.586836
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.26.586836
A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens cognitive performance in the APP/PS1 mouse model of Alzheimer’s disease (AD) [1]. We hypothesized that elevating Tc with thermotherapy would improve metabolism and cognition in APP/PS1 mice. From 6-12 months of age, male and female APP/PS1 and C57BL/6 mice were chronically housed at 23 or 30°C. At 12 months of age, mice were assayed for insulin sensitivity, glucose tolerance, and spatial cognition. Plasma, hippocampal, and peripheral (adipose, hepatic, and skeletal muscle) samples were procured postmortem and tissue-specific markers of amyloid accumulation, metabolism, and inflammation were assayed. Chronic 30°C exposure increased Tc in all groups except female APP/PS1 mice. All mice receiving thermotherapy had either improved glucose tolerance or insulin sensitivity, but the underlying processes responsible for these effects varied across sexes. In males, glucose regulation was influenced predominantly by hormonal signaling in plasma and skeletal muscle glucose transporter 4 expression, whereas in females, this was modulated at the tissue level. Thermotherapy improved spatial navigation in male C57BL/6 and APP/PS1 mice, with the later attributed to reduced hippocampal soluble amyloid-β (Aβ) 42 . Female APP/PS1 mice exhibited worse spatial memory recall after chronic thermotherapy. Together, the data highlights the metabolic benefits of passive thermotherapy, but future studies are needed to determine therapeutic benefits for those with AD.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.03.26.586836
- https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.26.586836.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393319592
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393319592Canonical identifier for this work in OpenAlex
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https://doi.org/10.1101/2024.03.26.586836Digital Object Identifier
- Title
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Thermotherapy has Sexually Dimorphic Responses in APP/PS1 MiceWork title
- Type
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preprintOpenAlex work type
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-29Full publication date if available
- Authors
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Samuel McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz, Caleigh A. Findley, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R. Hascup, Kevin N. HascupList of authors in order
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https://doi.org/10.1101/2024.03.26.586836Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.26.586836.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.26.586836.full.pdfDirect OA link when available
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Sexual dimorphism, Psychology, Biology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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