Three-dimensional-printed polycaprolactone scaffolds with interconnected hollow-pipe structures for enhanced bone regeneration Article Swipe
Jiahua Duan
,
Dong Lei
,
Ling Chen
,
Yufeng Wang
,
Zhicheng Cao
,
Ming Zhang
,
Huikang Zhang
,
Zhengwei You
,
Qingqiang Yao
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/rb/rbac033
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/rb/rbac033
Three-dimensional (3D)-printed scaffolds are widely used in tissue engineering to help regenerate critical-sized bone defects. However, conventional scaffolds possess relatively simple porous structures that limit the delivery of oxygen and nutrients to cells, leading to insufficient bone regeneration. Accordingly, in the present study, perfusable and permeable polycaprolactone scaffolds with highly interconnected hollow-pipe structures that mimic natural micro-vascular networks are prepared by an indirect one-pot 3D-printing method. In vitro experiments demonstrate that hollow-pipe-structured (HPS) scaffolds promote cell attachment, proliferation, osteogenesis and angiogenesis compared to the normal non-hollow-pipe-structured scaffolds. Furthermore, in vivo studies reveal that HPS scaffolds enhance bone regeneration and vascularization in rabbit bone defects, as observed at 8 and 12 weeks, respectively. Thus, the fabricated HPS scaffolds are promising candidates for the repair of critical-sized bone defects.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/rb/rbac033
- https://academic.oup.com/rb/article-pdf/doi/10.1093/rb/rbac033/44103204/rbac033.pdf
- OA Status
- gold
- Cited By
- 16
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281954131
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- OpenAlex ID
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https://openalex.org/W4281954131Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/rb/rbac033Digital Object Identifier
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Three-dimensional-printed polycaprolactone scaffolds with interconnected hollow-pipe structures for enhanced bone regenerationWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
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Jiahua Duan, Dong Lei, Ling Chen, Yufeng Wang, Zhicheng Cao, Ming Zhang, Huikang Zhang, Zhengwei You, Qingqiang YaoList of authors in order
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https://doi.org/10.1093/rb/rbac033Publisher landing page
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https://academic.oup.com/rb/article-pdf/doi/10.1093/rb/rbac033/44103204/rbac033.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/rb/article-pdf/doi/10.1093/rb/rbac033/44103204/rbac033.pdfDirect OA link when available
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Polycaprolactone, Regeneration (biology), Biomedical engineering, 3d printed, Materials science, Tissue engineering, In vivo, Scaffold, Chemistry, Bone healing, Anatomy, Composite material, Cell biology, Engineering, Biotechnology, Medicine, Biology, PolymerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
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2025: 6, 2024: 5, 2023: 4, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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