Thrombolytic Salvage of the Frostbitten Upper Extremity: A Systematic Review Article Swipe
James J. Drinane
,
Adee J. Heiman
,
Joseph A. Ricci
,
Ashit Patel
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1177/1558944720940065
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1177/1558944720940065
Background Vascular thrombosis secondary to frostbite can lead to ischemic tissue damage in severe cases. Threatened extremities may be salvaged with thrombolytics to restore perfusion; however, current data are limited to single institution case series. The authors performed a systematic review to determine the efficacy of thrombolytic therapy in treating upper extremity frostbite. Methods PubMed, EBSCO, and Google Scholar were queried using the keywords “thrombolytics,” “frostbite,” “fibrinolytics,” and “tPA.” Exclusion criteria were failure to delineate anatomic parts injured, failure to report number of limbs salvaged, animal studies, and non-English language publications. Thrombolytic therapy was defined as intraarterial (IA) or intravenous (IV) administration of tissue plasminogen activator (tPA), alteplase, urokinase, streptokinase, or any tPA derivative. Results A total of 42 studies were identified, with 13 satisfying inclusion criteria. Eight studies reported catheter-directed IA thrombolysis, four reported systemic IV administration, and 1 reported both methods. A total of 157 patients received thrombolytics. In all, 73 upper extremity digits were treated by IA route and 136 digits were treated by IV route. Overall upper extremity digit salvage rate was 59%. There was a significantly higher salvage rate in digits treated by the IA route compared to the IV route. Conclusions Thrombolytics, particularly when administered by the intra-arterial route, are emerging as a promising treatment of severe frostbite of the upper extremity, increasing digit salvage rates.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1177/1558944720940065
- OA Status
- green
- Cited By
- 8
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3087514797
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3087514797Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1558944720940065Digital Object Identifier
- Title
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Thrombolytic Salvage of the Frostbitten Upper Extremity: A Systematic ReviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-16Full publication date if available
- Authors
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James J. Drinane, Adee J. Heiman, Joseph A. Ricci, Ashit PatelList of authors in order
- Landing page
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https://doi.org/10.1177/1558944720940065Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/9112743Direct OA link when available
- Concepts
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Medicine, Streptokinase, Frostbite, Urokinase, Thrombolysis, Fibrinolytic agent, Surgery, Salvage therapy, Reteplase, Tenecteplase, Tissue plasminogen activator, Internal medicine, Chemotherapy, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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2025: 2, 2024: 1, 2023: 2, 2022: 3Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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