Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2 Article Swipe

PDF

Annunziata Gaetana Cicatiello , Serena Sagliocchi , Annarita Nappi , Emery Di Cicco , Caterina Miro , Melania Murolo , Mariano Stornaiuolo , Monica Dentice ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1016/j.celrep.2022.110409

Thyroid hormones (THs) are key metabolic regulators coordinating short- and long-term energy needs. In skeletal muscle, THs modulate energy metabolism in pathophysiological conditions. Indeed, hypo- and hyperthyroidism are leading causes of muscle weakness and strength; however, the metabolic pathways underlying these effects are still poorly understood. Using molecular, biochemical, and isotope-tracing approaches combined with mass spectrometry and denervation experiments, we find that THs regulate glutamine metabolism and anaplerotic fluxes by up-regulating the glutamate pyruvate transaminase 2 (GPT2) gene. In humans, GPT2 autosomal recessive mutations cause a neurological syndrome characterized by intellectual disability, microcephaly, and progressive motor symptoms. Here, we demonstrate a role of the TH/GPT2 axis in skeletal muscle in which it regulates muscle weight and fiber diameter in resting and atrophic conditions and results in protection from muscle loss during atrophy. These results describe an anabolic route by which THs rewire glutamine metabolism toward the maintenance of muscle mass.

Related Topics

Concepts

Glutamine Metabolism Glutamate receptor Hormone Biochemistry Thyroid Glutamine synthetase Chemistry Mitochondrion Glutamate dehydrogenase Biology Endocrinology Internal medicine Amino acid Medicine Receptor

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.celrep.2022.110409
PDF: http://www.cell.com/article/S2211124722001334/pdf
OA Status: gold
Cited By: 23
References: 57
Related Works: 10
OpenAlex ID: https://openalex.org/W4214592411

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4214592411

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1016/j.celrep.2022.110409

Digital Object Identifier
Title: Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2022

Year of publication
Publication date: 2022-02-01

Full publication date if available
Authors: Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Emery Di Cicco, Caterina Miro, Melania Murolo, Mariano Stornaiuolo, Monica Dentice

List of authors in order
Landing page: https://doi.org/10.1016/j.celrep.2022.110409

Publisher landing page
PDF URL: https://www.cell.com/article/S2211124722001334/pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://www.cell.com/article/S2211124722001334/pdf

Direct OA link when available
Concepts: Glutamine, Metabolism, Glutamate receptor, Hormone, Biochemistry, Thyroid, Glutamine synthetase, Chemistry, Mitochondrion, Glutamate dehydrogenase, Biology, Endocrinology, Internal medicine, Amino acid, Medicine, Receptor

Top concepts (fields/topics) attached by OpenAlex
Cited by: 23

Total citation count in OpenAlex
Citations by year (recent): 2025: 8, 2024: 9, 2023: 4, 2022: 2

Per-year citation counts (last 5 years)
References (count): 57

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4214592411
doi	https://doi.org/10.1016/j.celrep.2022.110409
ids.doi	https://doi.org/10.1016/j.celrep.2022.110409
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/35196498
ids.openalex	https://openalex.org/W4214592411
fwci	4.84441721
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000410
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Alanine Transaminase
mesh[1].qualifier_ui	Q000378
mesh[1].descriptor_ui	D005973
mesh[1].is_major_topic	True
mesh[1].qualifier_name	metabolism
mesh[1].descriptor_name	Glutamine
mesh[2].qualifier_ui
mesh[2].descriptor_ui	D006801
mesh[2].is_major_topic	False
mesh[2].qualifier_name
mesh[2].descriptor_name	Humans
mesh[3].qualifier_ui	Q000235
mesh[3].descriptor_ui	D008607
mesh[3].is_major_topic	True
mesh[3].qualifier_name	genetics
mesh[3].descriptor_name	Intellectual Disability
mesh[4].qualifier_ui
mesh[4].descriptor_ui	D013963
mesh[4].is_major_topic	False
mesh[4].qualifier_name
mesh[4].descriptor_name	Thyroid Hormones
mesh[5].qualifier_ui
mesh[5].descriptor_ui	D000637
mesh[5].is_major_topic	False
mesh[5].qualifier_name
mesh[5].descriptor_name	Transaminases
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D000410
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Alanine Transaminase
mesh[7].qualifier_ui	Q000378
mesh[7].descriptor_ui	D005973
mesh[7].is_major_topic	True
mesh[7].qualifier_name	metabolism
mesh[7].descriptor_name	Glutamine
mesh[8].qualifier_ui
mesh[8].descriptor_ui	D006801
mesh[8].is_major_topic	False
mesh[8].qualifier_name
mesh[8].descriptor_name	Humans
mesh[9].qualifier_ui	Q000235
mesh[9].descriptor_ui	D008607
mesh[9].is_major_topic	True
mesh[9].qualifier_name	genetics
mesh[9].descriptor_name	Intellectual Disability
mesh[10].qualifier_ui
mesh[10].descriptor_ui	D013963
mesh[10].is_major_topic	False
mesh[10].qualifier_name
mesh[10].descriptor_name	Thyroid Hormones
mesh[11].qualifier_ui
mesh[11].descriptor_ui	D000637
mesh[11].is_major_topic	False
mesh[11].qualifier_name
mesh[11].descriptor_name	Transaminases
type	article
title	Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
biblio.issue	8
biblio.volume	38
biblio.last_page	110409
biblio.first_page	110409
topics[0].id	https://openalex.org/T10293
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9994000196456909
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2712
topics[0].subfield.display_name	Endocrinology, Diabetes and Metabolism
topics[0].display_name	Thyroid Disorders and Treatments
topics[1].id	https://openalex.org/T10748
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9976999759674072
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2712
topics[1].subfield.display_name	Endocrinology, Diabetes and Metabolism
topics[1].display_name	Growth Hormone and Insulin-like Growth Factors
topics[2].id	https://openalex.org/T10301
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9934999942779541
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	Mitochondrial Function and Pathology
is_xpac	False
apc_list.value	5200
apc_list.currency	USD
apc_list.value_usd	5200
apc_paid.value	5200
apc_paid.currency	USD
apc_paid.value_usd	5200
concepts[0].id	https://openalex.org/C2779349466
concepts[0].level	3
concepts[0].score	0.6972565054893494
concepts[0].wikidata	https://www.wikidata.org/wiki/Q181619
concepts[0].display_name	Glutamine
concepts[1].id	https://openalex.org/C62231903
concepts[1].level	2
concepts[1].score	0.6196706295013428
concepts[1].wikidata	https://www.wikidata.org/wiki/Q1057
concepts[1].display_name	Metabolism
concepts[2].id	https://openalex.org/C61174792
concepts[2].level	3
concepts[2].score	0.5810595750808716
concepts[2].wikidata	https://www.wikidata.org/wiki/Q420510
concepts[2].display_name	Glutamate receptor
concepts[3].id	https://openalex.org/C71315377
concepts[3].level	2
concepts[3].score	0.5697121620178223
concepts[3].wikidata	https://www.wikidata.org/wiki/Q11364
concepts[3].display_name	Hormone
concepts[4].id	https://openalex.org/C55493867
concepts[4].level	1
concepts[4].score	0.5440750122070312
concepts[4].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[4].display_name	Biochemistry
concepts[5].id	https://openalex.org/C526584372
concepts[5].level	2
concepts[5].score	0.5162927508354187
concepts[5].wikidata	https://www.wikidata.org/wiki/Q16399
concepts[5].display_name	Thyroid
concepts[6].id	https://openalex.org/C2779289688
concepts[6].level	4
concepts[6].score	0.4420432150363922
concepts[6].wikidata	https://www.wikidata.org/wiki/Q418306
concepts[6].display_name	Glutamine synthetase
concepts[7].id	https://openalex.org/C185592680
concepts[7].level	0
concepts[7].score	0.42293354868888855
concepts[7].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[7].display_name	Chemistry
concepts[8].id	https://openalex.org/C28859421
concepts[8].level	2
concepts[8].score	0.41315847635269165
concepts[8].wikidata	https://www.wikidata.org/wiki/Q39572
concepts[8].display_name	Mitochondrion
concepts[9].id	https://openalex.org/C2777202666
concepts[9].level	4
concepts[9].score	0.412364661693573
concepts[9].wikidata	https://www.wikidata.org/wiki/Q417383
concepts[9].display_name	Glutamate dehydrogenase
concepts[10].id	https://openalex.org/C86803240
concepts[10].level	0
concepts[10].score	0.4061931371688843
concepts[10].wikidata	https://www.wikidata.org/wiki/Q420
concepts[10].display_name	Biology
concepts[11].id	https://openalex.org/C134018914
concepts[11].level	1
concepts[11].score	0.3857171833515167
concepts[11].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[11].display_name	Endocrinology
concepts[12].id	https://openalex.org/C126322002
concepts[12].level	1
concepts[12].score	0.3857088088989258
concepts[12].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[12].display_name	Internal medicine
concepts[13].id	https://openalex.org/C515207424
concepts[13].level	2
concepts[13].score	0.20822232961654663
concepts[13].wikidata	https://www.wikidata.org/wiki/Q8066
concepts[13].display_name	Amino acid
concepts[14].id	https://openalex.org/C71924100
concepts[14].level	0
concepts[14].score	0.19445234537124634
concepts[14].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[14].display_name	Medicine
concepts[15].id	https://openalex.org/C170493617
concepts[15].level	2
concepts[15].score	0.0
concepts[15].wikidata	https://www.wikidata.org/wiki/Q208467
concepts[15].display_name	Receptor
keywords[0].id	https://openalex.org/keywords/glutamine
keywords[0].score	0.6972565054893494
keywords[0].display_name	Glutamine
keywords[1].id	https://openalex.org/keywords/metabolism
keywords[1].score	0.6196706295013428
keywords[1].display_name	Metabolism
keywords[2].id	https://openalex.org/keywords/glutamate-receptor
keywords[2].score	0.5810595750808716
keywords[2].display_name	Glutamate receptor
keywords[3].id	https://openalex.org/keywords/hormone
keywords[3].score	0.5697121620178223
keywords[3].display_name	Hormone
keywords[4].id	https://openalex.org/keywords/biochemistry
keywords[4].score	0.5440750122070312
keywords[4].display_name	Biochemistry
keywords[5].id	https://openalex.org/keywords/thyroid
keywords[5].score	0.5162927508354187
keywords[5].display_name	Thyroid
keywords[6].id	https://openalex.org/keywords/glutamine-synthetase
keywords[6].score	0.4420432150363922
keywords[6].display_name	Glutamine synthetase
keywords[7].id	https://openalex.org/keywords/chemistry
keywords[7].score	0.42293354868888855
keywords[7].display_name	Chemistry
keywords[8].id	https://openalex.org/keywords/mitochondrion
keywords[8].score	0.41315847635269165
keywords[8].display_name	Mitochondrion
keywords[9].id	https://openalex.org/keywords/glutamate-dehydrogenase
keywords[9].score	0.412364661693573
keywords[9].display_name	Glutamate dehydrogenase
keywords[10].id	https://openalex.org/keywords/biology
keywords[10].score	0.4061931371688843
keywords[10].display_name	Biology
keywords[11].id	https://openalex.org/keywords/endocrinology
keywords[11].score	0.3857171833515167
keywords[11].display_name	Endocrinology
keywords[12].id	https://openalex.org/keywords/internal-medicine
keywords[12].score	0.3857088088989258
keywords[12].display_name	Internal medicine
keywords[13].id	https://openalex.org/keywords/amino-acid
keywords[13].score	0.20822232961654663
keywords[13].display_name	Amino acid
keywords[14].id	https://openalex.org/keywords/medicine
keywords[14].score	0.19445234537124634
keywords[14].display_name	Medicine
language	en
locations[0].id	doi:10.1016/j.celrep.2022.110409
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S169236886
locations[0].source.issn	2211-1247, 2639-1856
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2211-1247
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Cell Reports
locations[0].source.host_organization	https://openalex.org/P4310315673
locations[0].source.host_organization_name	Cell Press
locations[0].source.host_organization_lineage	https://openalex.org/P4310315673, https://openalex.org/P4310320990
locations[0].source.host_organization_lineage_names	Cell Press, Elsevier BV
locations[0].license	cc-by
locations[0].pdf_url	http://www.cell.com/article/S2211124722001334/pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Cell Reports
locations[0].landing_page_url	https://doi.org/10.1016/j.celrep.2022.110409
locations[1].id	pmid:35196498
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Cell reports
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/35196498
locations[2].id	pmh:oai:pubmedcentral.nih.gov:8889437
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license	other-oa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/other-oa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	Cell Rep
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/8889437
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5068979800
authorships[0].author.orcid	https://orcid.org/0000-0002-6008-7086
authorships[0].author.display_name	Annunziata Gaetana Cicatiello
authorships[0].countries	IT
authorships[0].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[0].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[0].institutions[0].id	https://openalex.org/I71267560
authorships[0].institutions[0].ror	https://ror.org/05290cv24
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I71267560
authorships[0].institutions[0].country_code	IT
authorships[0].institutions[0].display_name	University of Naples Federico II
authorships[0].author_position	first
authorships[0].raw_author_name	Annunziata Gaetana Cicatiello
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[1].author.id	https://openalex.org/A5067774128
authorships[1].author.orcid	https://orcid.org/0000-0003-0796-1392
authorships[1].author.display_name	Serena Sagliocchi
authorships[1].countries	IT
authorships[1].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[1].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[1].institutions[0].id	https://openalex.org/I71267560
authorships[1].institutions[0].ror	https://ror.org/05290cv24
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I71267560
authorships[1].institutions[0].country_code	IT
authorships[1].institutions[0].display_name	University of Naples Federico II
authorships[1].author_position	middle
authorships[1].raw_author_name	Serena Sagliocchi
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[2].author.id	https://openalex.org/A5038272164
authorships[2].author.orcid	https://orcid.org/0000-0002-0876-3323
authorships[2].author.display_name	Annarita Nappi
authorships[2].countries	IT
authorships[2].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[2].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[2].institutions[0].id	https://openalex.org/I71267560
authorships[2].institutions[0].ror	https://ror.org/05290cv24
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I71267560
authorships[2].institutions[0].country_code	IT
authorships[2].institutions[0].display_name	University of Naples Federico II
authorships[2].author_position	middle
authorships[2].raw_author_name	Annarita Nappi
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[3].author.id	https://openalex.org/A5069708596
authorships[3].author.orcid	https://orcid.org/0000-0001-8507-1809
authorships[3].author.display_name	Emery Di Cicco
authorships[3].countries	IT
authorships[3].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[3].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[3].institutions[0].id	https://openalex.org/I71267560
authorships[3].institutions[0].ror	https://ror.org/05290cv24
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I71267560
authorships[3].institutions[0].country_code	IT
authorships[3].institutions[0].display_name	University of Naples Federico II
authorships[3].author_position	middle
authorships[3].raw_author_name	Emery Di Cicco
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[4].author.id	https://openalex.org/A5034047818
authorships[4].author.orcid	https://orcid.org/0000-0002-1008-8443
authorships[4].author.display_name	Caterina Miro
authorships[4].countries	IT
authorships[4].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[4].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[4].institutions[0].id	https://openalex.org/I71267560
authorships[4].institutions[0].ror	https://ror.org/05290cv24
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I71267560
authorships[4].institutions[0].country_code	IT
authorships[4].institutions[0].display_name	University of Naples Federico II
authorships[4].author_position	middle
authorships[4].raw_author_name	Caterina Miro
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[5].author.id	https://openalex.org/A5004762692
authorships[5].author.orcid	https://orcid.org/0000-0001-7930-9905
authorships[5].author.display_name	Melania Murolo
authorships[5].countries	IT
authorships[5].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[5].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[5].institutions[0].id	https://openalex.org/I71267560
authorships[5].institutions[0].ror	https://ror.org/05290cv24
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I71267560
authorships[5].institutions[0].country_code	IT
authorships[5].institutions[0].display_name	University of Naples Federico II
authorships[5].author_position	middle
authorships[5].raw_author_name	Melania Murolo
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[6].author.id	https://openalex.org/A5037952913
authorships[6].author.orcid	https://orcid.org/0000-0003-2200-5083
authorships[6].author.display_name	Mariano Stornaiuolo
authorships[6].countries	IT
authorships[6].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[6].affiliations[0].raw_affiliation_string	Department of Pharmacy, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[6].institutions[0].id	https://openalex.org/I71267560
authorships[6].institutions[0].ror	https://ror.org/05290cv24
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I71267560
authorships[6].institutions[0].country_code	IT
authorships[6].institutions[0].display_name	University of Naples Federico II
authorships[6].author_position	middle
authorships[6].raw_author_name	Mariano Stornaiuolo
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Pharmacy, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[7].author.id	https://openalex.org/A5009426718
authorships[7].author.orcid	https://orcid.org/0000-0002-9977-3761
authorships[7].author.display_name	Monica Dentice
authorships[7].countries	IT
authorships[7].affiliations[0].institution_ids	https://openalex.org/I71267560
authorships[7].affiliations[0].raw_affiliation_string	Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
authorships[7].affiliations[1].institution_ids	https://openalex.org/I4210128854
authorships[7].affiliations[1].raw_affiliation_string	CEINGE–Biotecnologie Avanzate Scarl, Naples, NA 80131, Italy
authorships[7].institutions[0].id	https://openalex.org/I4210128854
authorships[7].institutions[0].ror	https://ror.org/033pa2k60
authorships[7].institutions[0].type	company
authorships[7].institutions[0].lineage	https://openalex.org/I4210128854
authorships[7].institutions[0].country_code	IT
authorships[7].institutions[0].display_name	Ceinge Biotecnologie Avanzate (Italy)
authorships[7].institutions[1].id	https://openalex.org/I71267560
authorships[7].institutions[1].ror	https://ror.org/05290cv24
authorships[7].institutions[1].type	education
authorships[7].institutions[1].lineage	https://openalex.org/I71267560
authorships[7].institutions[1].country_code	IT
authorships[7].institutions[1].display_name	University of Naples Federico II
authorships[7].author_position	last
authorships[7].raw_author_name	Monica Dentice
authorships[7].is_corresponding	True
authorships[7].raw_affiliation_strings	CEINGE–Biotecnologie Avanzate Scarl, Naples, NA 80131, Italy, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, NA 80138 Italy
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	http://www.cell.com/article/S2211124722001334/pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10293
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9994000196456909
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2712
primary_topic.subfield.display_name	Endocrinology, Diabetes and Metabolism
primary_topic.display_name	Thyroid Disorders and Treatments
related_works	https://openalex.org/W2040069641, https://openalex.org/W1758419501, https://openalex.org/W2022749662, https://openalex.org/W2019593662, https://openalex.org/W2036529175, https://openalex.org/W4213409523, https://openalex.org/W1999720855, https://openalex.org/W2067537102, https://openalex.org/W2626000720, https://openalex.org/W82993901
cited_by_count	23
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	8
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	9
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	4
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	2
locations_count	3
best_oa_location.id	doi:10.1016/j.celrep.2022.110409
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S169236886
best_oa_location.source.issn	2211-1247, 2639-1856
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2211-1247
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Cell Reports
best_oa_location.source.host_organization	https://openalex.org/P4310315673
best_oa_location.source.host_organization_name	Cell Press
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310315673, https://openalex.org/P4310320990
best_oa_location.source.host_organization_lineage_names	Cell Press, Elsevier BV
best_oa_location.license	cc-by
best_oa_location.pdf_url	http://www.cell.com/article/S2211124722001334/pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Cell Reports
best_oa_location.landing_page_url	https://doi.org/10.1016/j.celrep.2022.110409
primary_location.id	doi:10.1016/j.celrep.2022.110409
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S169236886
primary_location.source.issn	2211-1247, 2639-1856
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2211-1247
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Cell Reports
primary_location.source.host_organization	https://openalex.org/P4310315673
primary_location.source.host_organization_name	Cell Press
primary_location.source.host_organization_lineage	https://openalex.org/P4310315673, https://openalex.org/P4310320990
primary_location.source.host_organization_lineage_names	Cell Press, Elsevier BV
primary_location.license	cc-by
primary_location.pdf_url	http://www.cell.com/article/S2211124722001334/pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Cell Reports
primary_location.landing_page_url	https://doi.org/10.1016/j.celrep.2022.110409
publication_date	2022-02-01
publication_year	2022
referenced_works	https://openalex.org/W2061116193, https://openalex.org/W3049095145, https://openalex.org/W2110751316, https://openalex.org/W1989106010, https://openalex.org/W94881481, https://openalex.org/W2149451793, https://openalex.org/W2097615700, https://openalex.org/W2800545651, https://openalex.org/W2167033587, https://openalex.org/W1982650718, https://openalex.org/W2022349101, https://openalex.org/W2133650808, https://openalex.org/W2956821648, https://openalex.org/W2474066613, https://openalex.org/W2906310843, https://openalex.org/W2060446663, https://openalex.org/W1993038196, https://openalex.org/W2416416669, https://openalex.org/W4238372547, https://openalex.org/W2156967886, https://openalex.org/W2084889190, https://openalex.org/W2047308744, https://openalex.org/W6603813405, https://openalex.org/W2807102597, https://openalex.org/W1983693385, https://openalex.org/W2338843858, https://openalex.org/W2107277218, https://openalex.org/W2947985436, https://openalex.org/W1973276229, https://openalex.org/W3173095582, https://openalex.org/W2083792240, https://openalex.org/W1966824338, https://openalex.org/W3175029578, https://openalex.org/W1658568866, https://openalex.org/W2123954892, https://openalex.org/W2517626590, https://openalex.org/W2134294998, https://openalex.org/W2168795583, https://openalex.org/W1969213944, https://openalex.org/W2946144257, https://openalex.org/W1981948323, https://openalex.org/W1966955508, https://openalex.org/W2060038372, https://openalex.org/W2531263810, https://openalex.org/W1991413218, https://openalex.org/W2140166139, https://openalex.org/W1565313690, https://openalex.org/W2814272328, https://openalex.org/W2064651077, https://openalex.org/W1966094526, https://openalex.org/W2128766922, https://openalex.org/W2146646206, https://openalex.org/W6673318890, https://openalex.org/W2009202587, https://openalex.org/W1964184380, https://openalex.org/W2090187795, https://openalex.org/W2031622188
referenced_works_count	57
abstract_inverted_index.2	75
abstract_inverted_index.a	85, 100
abstract_inverted_index.In	13, 78
abstract_inverted_index.an	135
abstract_inverted_index.by	69, 89, 138
abstract_inverted_index.in	20, 106, 109, 118, 125
abstract_inverted_index.it	111
abstract_inverted_index.of	30, 102, 147
abstract_inverted_index.we	59, 98
abstract_inverted_index.THs	16, 62, 140
abstract_inverted_index.and	9, 25, 33, 49, 56, 66, 93, 115, 120, 123
abstract_inverted_index.are	3, 27, 42
abstract_inverted_index.key	4
abstract_inverted_index.the	36, 71, 103, 145
abstract_inverted_index.GPT2	80
abstract_inverted_index.axis	105
abstract_inverted_index.find	60
abstract_inverted_index.from	127
abstract_inverted_index.loss	129
abstract_inverted_index.mass	54
abstract_inverted_index.role	101
abstract_inverted_index.that	61
abstract_inverted_index.with	53
abstract_inverted_index.(THs)	2
abstract_inverted_index.Here,	97
abstract_inverted_index.These	132
abstract_inverted_index.Using	46
abstract_inverted_index.cause	84
abstract_inverted_index.fiber	116
abstract_inverted_index.gene.	77
abstract_inverted_index.hypo-	24
abstract_inverted_index.mass.	149
abstract_inverted_index.motor	95
abstract_inverted_index.route	137
abstract_inverted_index.still	43
abstract_inverted_index.these	40
abstract_inverted_index.which	110, 139
abstract_inverted_index.(GPT2)	76
abstract_inverted_index.causes	29
abstract_inverted_index.during	130
abstract_inverted_index.energy	11, 18
abstract_inverted_index.fluxes	68
abstract_inverted_index.muscle	31, 108, 113, 128, 148
abstract_inverted_index.needs.	12
abstract_inverted_index.poorly	44
abstract_inverted_index.rewire	141
abstract_inverted_index.short-	8
abstract_inverted_index.toward	144
abstract_inverted_index.weight	114
abstract_inverted_index.Indeed,	23
abstract_inverted_index.TH/GPT2	104
abstract_inverted_index.Thyroid	0
abstract_inverted_index.effects	41
abstract_inverted_index.humans,	79
abstract_inverted_index.leading	28
abstract_inverted_index.muscle,	15
abstract_inverted_index.resting	119
abstract_inverted_index.results	124, 133
abstract_inverted_index.anabolic	136
abstract_inverted_index.atrophic	121
abstract_inverted_index.atrophy.	131
abstract_inverted_index.combined	52
abstract_inverted_index.describe	134
abstract_inverted_index.diameter	117
abstract_inverted_index.hormones	1
abstract_inverted_index.however,	35
abstract_inverted_index.modulate	17
abstract_inverted_index.pathways	38
abstract_inverted_index.pyruvate	73
abstract_inverted_index.regulate	63
abstract_inverted_index.skeletal	14, 107
abstract_inverted_index.syndrome	87
abstract_inverted_index.weakness	32
abstract_inverted_index.autosomal	81
abstract_inverted_index.glutamate	72
abstract_inverted_index.glutamine	64, 142
abstract_inverted_index.long-term	10
abstract_inverted_index.metabolic	5, 37
abstract_inverted_index.mutations	83
abstract_inverted_index.recessive	82
abstract_inverted_index.regulates	112
abstract_inverted_index.strength;	34
abstract_inverted_index.symptoms.	96
abstract_inverted_index.approaches	51
abstract_inverted_index.conditions	122
abstract_inverted_index.metabolism	19, 65, 143
abstract_inverted_index.molecular,	47
abstract_inverted_index.protection	126
abstract_inverted_index.regulators	6
abstract_inverted_index.underlying	39
abstract_inverted_index.anaplerotic	67
abstract_inverted_index.conditions.	22
abstract_inverted_index.demonstrate	99
abstract_inverted_index.denervation	57
abstract_inverted_index.disability,	91
abstract_inverted_index.maintenance	146
abstract_inverted_index.progressive	94
abstract_inverted_index.understood.	45
abstract_inverted_index.biochemical,	48
abstract_inverted_index.coordinating	7
abstract_inverted_index.experiments,	58
abstract_inverted_index.intellectual	90
abstract_inverted_index.neurological	86
abstract_inverted_index.spectrometry	55
abstract_inverted_index.transaminase	74
abstract_inverted_index.characterized	88
abstract_inverted_index.microcephaly,	92
abstract_inverted_index.up-regulating	70
abstract_inverted_index.hyperthyroidism	26
abstract_inverted_index.isotope-tracing	50
abstract_inverted_index.pathophysiological	21
cited_by_percentile_year.max	99
cited_by_percentile_year.min	94
corresponding_author_ids	https://openalex.org/A5009426718
countries_distinct_count	1
institutions_distinct_count	8
corresponding_institution_ids	https://openalex.org/I4210128854, https://openalex.org/I71267560
sustainable_development_goals[0].id	https://metadata.un.org/sdg/7
sustainable_development_goals[0].score	0.7099999785423279
sustainable_development_goals[0].display_name	Affordable and clean energy
citation_normalized_percentile.value	0.93431244
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True