THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis Article Swipe
Zachary D. Taylor
,
James Garritano
,
Shijun Sung
,
Neha Bajwa
,
David Bennett
,
Bryan Nowroozi
,
Priyamvada Tewari
,
James Sayre
,
Jean‐Pierre Hubschman
,
Sophie X. Deng
,
E. R. Brown
,
Warren S. Grundfest
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2015.2392619
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2015.2392619
Terahertz (THz) spectral properties of human cornea are explored as a function of central corneal thickness (CCT) and corneal water content, and the clinical utility of THz-based corneal water content sensing is discussed. Three candidate corneal tissue water content (CTWC) perturbations, based on corneal physiology, are investigated that affect the axial water distribution and total thickness. The THz frequency reflectivity properties of the three CTWC perturbations were simulated and explored with varying system center frequency and bandwidths (Q-factors). The modeling showed that at effective optical path lengths on the order of a wavelength the cornea presents a lossy etalon bordered by air at the anterior and the aqueous humor at the posterior. The simulated standing wave peak-to-valley ratio is pronounced at lower frequencies and its effect on acquired data can be modulated by adjusting the bandwidth of the sensing system. These observations are supported with experimental spectroscopic data. The results suggest that a priori knowledge of corneal thickness can be utilized for accurate assessments of corneal tissue water content. The physiologic variation of corneal thickness with respect to the wavelengths spanned by the THz band is extremely limited compared to all other structures in the body making CTWC sensing unique amongst all proposed applications of THz medical imaging.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1109/tthz.2015.2392619
- OA Status
- green
- Cited By
- 94
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2137437106
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2137437106Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1109/tthz.2015.2392619Digital Object Identifier
- Title
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THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-02-18Full publication date if available
- Authors
-
Zachary D. Taylor, James Garritano, Shijun Sung, Neha Bajwa, David Bennett, Bryan Nowroozi, Priyamvada Tewari, James Sayre, Jean‐Pierre Hubschman, Sophie X. Deng, E. R. Brown, Warren S. GrundfestList of authors in order
- Landing page
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https://doi.org/10.1109/tthz.2015.2392619Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1109/TTHZ.2015.2392619Direct OA link when available
- Concepts
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Terahertz radiation, Cornea, Materials science, Optics, Wavelength, Biomedical engineering, Optoelectronics, Physics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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94Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 9, 2023: 12, 2022: 15, 2021: 17Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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