THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results Article Swipe
Zachary Taylor
,
James Garritano
,
Shijun Sung
,
Neha Bajwa
,
David Bennett
,
Bryan Nowroozi
,
Priyamvada Tewari
,
James Sayre
,
Jean‐Pierre Hubschman
,
Sophie X. Deng
,
E. R. Brown
,
Warren S. Grundfest
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2015.2392628
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2015.2392628
A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea in vivo. These imaging results are the first ever produced of in vivo cornea. A modified version of a standard protocol using a gentle stream of air and a Mylar window was employed to slightly dehydrate healthy cornea. The sensor data and companion central corneal thickness (CCT) measurements were acquired every 10-15 min over the course of two hours using ultrasound pachymmetry.. Statistically significant positive correlations were established between CCT measurements and millimeter wave reflectivity. Local shifts in reflectivity contrast were observed in the THz imagery; however, the THz reflectivity did not display a significant correlation with thickness in the region probed by the 100 GHz and CCT measurements. This is explained in part by a thickness sensitivity at least 10× higher in the mm-wave than the THz systems. Stratified media and effective media modeling suggest that the protocol perturbed the thickness and not the corneal tissue water content (CTWC). To further explore possible etalon effects, an additional rabbit was euthanized and millimeter wave measurements were obtained during death induced edema. These observations represent the first time that the uncoupled sensing of CTWC and CCT have been achieved in vivo.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1109/tthz.2015.2392628
- OA Status
- green
- Cited By
- 117
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2070912349
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2070912349Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1109/tthz.2015.2392628Digital Object Identifier
- Title
-
THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging ResultsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-02-18Full publication date if available
- Authors
-
Zachary Taylor, James Garritano, Shijun Sung, Neha Bajwa, David Bennett, Bryan Nowroozi, Priyamvada Tewari, James Sayre, Jean‐Pierre Hubschman, Sophie X. Deng, E. R. Brown, Warren S. GrundfestList of authors in order
- Landing page
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https://doi.org/10.1109/tthz.2015.2392628Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/4493917Direct OA link when available
- Concepts
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Terahertz radiation, Cornea, Materials science, Optics, Extremely high frequency, Ultrasound, Millimeter, Biomedical engineering, Optoelectronics, Medicine, Physics, RadiologyTop concepts (fields/topics) attached by OpenAlex
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117Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 4, 2023: 6, 2022: 19, 2021: 24Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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