THz Imaging System for in vivo Human Cornea Article Swipe
Shijun Sung
,
E. R. Brown
,
Warren S. Grundfest
,
Zachary D. Taylor
,
Skyler Selvin
,
Neha Bajwa
,
Somporn Chantra
,
Bryan Nowroozi
,
James Garritano
,
Jacob Goell
,
Alexander D. Li
,
Sophie X. Deng
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2017.2775445
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1109/tthz.2017.2775445
Terahertz (THz) imaging of corneal tissue water content (CTWC) is a proposed method for early, accurate detection and study of corneal diseases. Despite promising results from ex vivo and in vivo cornea studies, interpretation of the reflectivity data is confounded by the contact between corneal tissue and rigid dielectric window used to flatten the imaging field. This work develops a novel imaging system and image reconstruction methods specifically for nearly spherical targets such as human cornea. A prototype system was constructed using a 650 GHz multiplier source and Schottky diode detector. Resolution and imaging field strength measurement from characterization targets correlate well with those predicted by the quasioptical theory and physical optics analysis. Imaging experiments with corneal phantoms and ex vivo corneas demonstrate the hydration sensitivity of the imaging system and reliable measurement of CTWC. We present successful acquisition of non-contact THz images of in vivo human cornea, and discuss strategies for optimizing the imaging system design for clinical use.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1109/tthz.2017.2775445
- OA Status
- green
- Cited By
- 71
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2771648048
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2771648048Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1109/tthz.2017.2775445Digital Object Identifier
- Title
-
THz Imaging System for in vivo Human CorneaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-12-07Full publication date if available
- Authors
-
Shijun Sung, E. R. Brown, Warren S. Grundfest, Zachary D. Taylor, Skyler Selvin, Neha Bajwa, Somporn Chantra, Bryan Nowroozi, James Garritano, Jacob Goell, Alexander D. Li, Sophie X. DengList of authors in order
- Landing page
-
https://doi.org/10.1109/tthz.2017.2775445Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/5805158Direct OA link when available
- Concepts
-
Cornea, Terahertz radiation, Optics, Materials science, Ex vivo, Medical imaging, Preclinical imaging, Optical coherence tomography, Biomedical engineering, In vivo, Computer science, Physics, Medicine, Artificial intelligence, Biotechnology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
71Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 6, 2023: 9, 2022: 14, 2021: 18Per-year citation counts (last 5 years)
- References (count)
-
15Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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