Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex Article Swipe
Haleigh N Mulholland
,
Bettina Hein
,
Matthias Kaschube
,
Gordon B. Smith
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7554/elife.72456
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7554/elife.72456
Intracortical inhibition plays a critical role in shaping activity patterns in the mature cortex. However, little is known about the structure of inhibition in early development prior to the onset of sensory experience, a time when spontaneous activity exhibits long-range correlations predictive of mature functional networks. Here, using calcium imaging of GABAergic neurons in the ferret visual cortex, we show that spontaneous activity in inhibitory neurons is already highly organized into distributed modular networks before visual experience. Inhibitory neurons exhibit spatially modular activity with long-range correlations and precise local organization that is in quantitative agreement with excitatory networks. Furthermore, excitatory and inhibitory networks are strongly co-aligned at both millimeter and cellular scales. These results demonstrate a remarkable degree of organization in inhibitory networks early in the developing cortex, providing support for computational models of self-organizing networks and suggesting a mechanism for the emergence of distributed functional networks during development.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.72456
- OA Status
- gold
- Cited By
- 27
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200344471
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4200344471Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.72456Digital Object Identifier
- Title
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Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortexWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-11-12Full publication date if available
- Authors
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Haleigh N Mulholland, Bettina Hein, Matthias Kaschube, Gordon B. SmithList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.72456Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.72456Direct OA link when available
- Concepts
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Inhibitory postsynaptic potential, Neuroscience, Excitatory postsynaptic potential, Visual cortex, GABAergic, Sensory system, Cortex (anatomy), Biology, Calcium imaging, Chemistry, Calcium, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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-
27Total citation count in OpenAlex
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2025: 9, 2024: 11, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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