Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation Article Swipe
Mostafa Abdollahpur
,
Chiara Celotto
,
Carlos Sánchez
,
Felix Plappert
,
Sten Östenson
,
Pyotr G. Platonov
,
Pablo Laguna
,
Esther Pueyo
,
Frida Sandberg
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2025.1498426
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2025.1498426
Introduction This study explores transient and stationary effects of sympathetic and parasympathetic stimulation on f-wave characteristics in atrial fibrillation (AF) patients undergoing a tilt test. Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 minutes post-change until phase end) representing a stable autonomic state. Methods Our primary aim is to investigate how the two branches of the autonomic nervous system (ANS) influence the f-wave frequency time series ( ). An analysis of in terms of the mean over time ( ) and the magnitude of respiration-modulated variations ( ) is conducted during baseline supine rest (B), head-down tilt (HDT) and head-up tilt (HUT). We analyzed data from a previous study in which 24 patients with persistent AF underwent a tilt test protocol, during which electrocardiograms (ECGs) were recorded. A model-based method was used to extract series from the ECG. Subsequently, an orthogonal subspace projection method was employed to quantify , considering an ECG-derived respiratory signal. Electrophysiological computational simulations were conducted on 2D and 3D human atrial persistent AF models to aid the interpretation of clinical findings. Various levels of cholinergic stimulation by acetylcholine and -adrenergic stimulation by isoproterenol were tested in the models. The temporal modulation of acetylcholine, representing changes associated with respiration, was cyclically modeled using sinusoidal waveforms. Results Analysis of the clinical data showed a decrease in from B to HDT and an increase from HDT to HUT. During HDT, initially increased in the transient phase before decreasing in the steady phase, then rose again during HUT. Analysis of the simulated data showed that increasing the concentration of Isoproterenol and/or acetylcholine resulted in a rise in . Additionally, the magnitude of was shown to be associated with the extent of acetylcholine fluctuation. Discussion These results suggest that changes in f-wave frequency characteristics during HUT and HDT could be linked to changes in sympathetic activity, with parasympathetic activity possibly modulating the effects of sympathetic activity rather than being an independent driver of fibrillatory rate changes.
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- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphys.2025.1498426
- https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1498426/pdf
- OA Status
- gold
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411295460
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https://openalex.org/W4411295460Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphys.2025.1498426Digital Object Identifier
- Title
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Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-13Full publication date if available
- Authors
-
Mostafa Abdollahpur, Chiara Celotto, Carlos Sánchez, Felix Plappert, Sten Östenson, Pyotr G. Platonov, Pablo Laguna, Esther Pueyo, Frida SandbergList of authors in order
- Landing page
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https://doi.org/10.3389/fphys.2025.1498426Publisher landing page
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https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1498426/pdfDirect link to full text PDF
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1498426/pdfDirect OA link when available
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Algorithm, Artificial intelligence, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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| abstract_inverted_index.mathvariant="script">F</mml:mi></mml:mrow><mml:mrow><mml:mi>f</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> | 351 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5030735098 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I187531555 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.4300000071525574 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.35479359 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |