Time-course of right-hemisphere recruitment during word production following lefthemisphere damage: A single case of young stroke Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.31234/osf.io/x53he
Our understanding of post-stroke language function is largely based on older age groups, who show increasing age-related brain pathology and neural reorganisation. To illustrate language outcomes in the young-adult brain, we present the case of A., a 23 y.o. woman with chronic aphasia from a left-hemisphere stroke affecting the temporal lobe. Diffusion MRI-based tractography indicated that A.’s language-relevant white matter structures were severely damaged. Using magnetoencephalography (MEG), we explored A.’s conceptual preparation and word planning abilities. Context-driven and bare picture-naming tasks revealed naming deficits, manifesting as word-finding difficulties and semantic paraphasias about half of the time. Naming was however facilitated by semantically constraining lead-in sentences. Altogether, this pattern indicates relatively spared conceptual preparation but disrupted lexical and phonological retrieval abilities. MEG revealed that A.’s conceptual and naming-related neural responses were supported by the right hemisphere, compared to the typical left-lateralised brain response of a matched control. Differential recruitment of right-hemisphere structures (330-440 ms postpicture onset) was found concurrently during successful naming (right mid-to-posterior temporal lobe) and word-finding attempts (right inferior frontal gyrus). Disconnection of the temporal lobes via corpus callosum was not critical for recruitment of the right hemisphere in visually guided naming, possibly due to neural activity right-lateralising from the outset. We consider that, despite A.’s young age, the presumed strong degree of language lateralisation and extensive structural damage limited her recovery. Although A.’s right hemisphere responded in a timely manner during word planning, its lexical and phonological retrieval abilities remained modest.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.31234/osf.io/x53he
- https://psyarxiv.com/x53he/download
- OA Status
- gold
- Cited By
- 1
- References
- 168
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200235616
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200235616Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31234/osf.io/x53heDigital Object Identifier
- Title
-
Time-course of right-hemisphere recruitment during word production following lefthemisphere damage: A single case of young strokeWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-29Full publication date if available
- Authors
-
Irina Chupina, Joanna Sierpowska, Xiaochen Zheng, Anna Dewenter, Maria Carla Piastra, Vitória PiaiList of authors in order
- Landing page
-
https://doi.org/10.31234/osf.io/x53hePublisher landing page
- PDF URL
-
https://psyarxiv.com/x53he/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://psyarxiv.com/x53he/downloadDirect OA link when available
- Concepts
-
Psychology, Lateralization of brain function, Aphasia, Disconnection, Context (archaeology), Magnetoencephalography, Right hemisphere, Arcuate fasciculus, Corpus callosum, Cognitive psychology, Temporal lobe, Audiology, White matter, Tractography, Neuroscience, Medicine, Magnetic resonance imaging, Epilepsy, Biology, Paleontology, Law, Political science, Radiology, ElectroencephalographyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
-
168Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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