Timed collinear activation of Hox genes during gastrulation controls the avian forelimb position Article Swipe
Chloé Moreau
,
Paolo Caldarelli
,
Didier Rocancourt
,
Julian Roussel
,
Nicolas Denans
,
Olivier Pourquié
,
Jérôme Gros
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/351106
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/351106
Summary Limb position along the body is highly consistent within one species but very variable among vertebrates. Despite major advances in our understanding of limb patterning in three dimensions, how limbs reproducibly form along the anteroposterior axis remains largely unknown. Hox genes have long been suspected to control limb position, however supporting evidences are mostly correlative and their role in this process remains unclear. Here we show that Hox genes determine the avian forelimb position in a two-step process: first, their sequential collinear activation during gastrulation controls the relative position of their own successive expression domains along the body axis. Then, within these collinear domains, Hox genes differentially activate or repress the genetic cascade responsible for forelimb initiation. Furthermore, we provide evidences that changes in the timing of collinear Hox gene activation might underlie natural variation in forelimb position between different birds. Altogether our results which characterize the cellular and molecular mechanisms underlying the regulation and natural variation of forelimb position in avians, show a direct and early role for Hox genes in this process.
Related Topics
Concepts
Hox gene
Forelimb
Gastrulation
Biology
Gene
Evolutionary biology
Genetics
Anatomy
Gene expression
Embryogenesis
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/351106
- https://www.biorxiv.org/content/biorxiv/early/2018/06/20/351106.full.pdf
- OA Status
- green
- Cited By
- 10
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2808991044
All OpenAlex metadata
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https://doi.org/10.1101/351106Digital Object Identifier
- Title
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Timed collinear activation of Hox genes during gastrulation controls the avian forelimb positionWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-06-20Full publication date if available
- Authors
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Chloé Moreau, Paolo Caldarelli, Didier Rocancourt, Julian Roussel, Nicolas Denans, Olivier Pourquié, Jérôme GrosList of authors in order
- Landing page
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https://doi.org/10.1101/351106Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2018/06/20/351106.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2018/06/20/351106.full.pdfDirect OA link when available
- Concepts
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Hox gene, Forelimb, Gastrulation, Biology, Gene, Evolutionary biology, Genetics, Anatomy, Gene expression, EmbryogenesisTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2024: 2, 2023: 2, 2019: 5, 2018: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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