Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla Article Swipe
Parul Singh
,
Arun Rawat
,
Marwa Saadaoui
,
Duaa Ahmed Elhag
,
Sara Tomei
,
Mohammed Elanbari
,
Anthony K Akobeng
,
Amira Mustafa
,
Ibtihal Abdelgadir
,
Sharda Udassi
,
Mohammed A. Hendaus
,
Souhaila Al Khodor
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10020278
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10020278
Vitamin D inadequacy appears to be on the rise globally, and it has been linked to an increased risk of osteoporosis, as well as metabolic, cardiovascular, and autoimmune diseases. Vitamin D concentrations are partially determined by genetic factors. Specific single nucleotide polymorphisms (SNPs) in genes involved in vitamin D transport, metabolism, or binding have been found to be associated with its serum concentration, and these SNPs differ among ethnicities. Vitamin D has also been suggested to be a regulator of the gut microbiota and vitamin D deficiency as the possible cause of gut microbial dysbiosis and inflammation. This pilot study aims to fill the gap in our understanding of the prevalence, cause, and implications of vitamin D inadequacy in a pediatric population residing in Qatar. Blood and fecal samples were collected from healthy subjects aged 4–14 years. Blood was used to measure serum metabolite of vitamin D, 25-hydroxycholecalciferol 25(OH)D. To evaluate the composition of the gut microbiota, fecal samples were subjected to 16S rRNA gene sequencing. High levels of vitamin D deficiency/insufficiency were observed in our cohort with 97% of the subjects falling into the inadequate category (with serum 25(OH)D < 75 nmol/L). The CT genotype in rs12512631, an SNP in the GC gene, was associated with low serum levels of vitamin D (ANOVA, p = 0.0356) and was abundant in deficient compared to non-deficient subjects. Overall gut microbial community structure was significantly different between the deficient (D) and non-deficient (ND) groups (Bray Curtis dissimilarity p = 0.049), with deficient subjects also displaying reduced gut microbial diversity. Significant differences were observed among the two major gut phyla, Firmicutes (F) and Bacteroidetes (B), where deficient subjects displayed a higher B/F ratio (p = 0.0097) compared to ND. Vitamin D deficient children also demonstrated gut enterotypes dominated by the genus Prevotella as opposed to Bacteroides. Our findings suggest that pediatric vitamin D inadequacy significantly impacts the gut microbiota. We also highlight the importance of considering host genetics and baseline gut microbiome composition in interpreting the clinical outcomes related to vitamin D deficiency as well as designing better personalized strategies for therapeutic interventions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines10020278
- https://www.mdpi.com/2227-9059/10/2/278/pdf?version=1643350865
- OA Status
- gold
- Cited By
- 13
- References
- 123
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210819748
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210819748Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines10020278Digital Object Identifier
- Title
-
Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial PhylaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-26Full publication date if available
- Authors
-
Parul Singh, Arun Rawat, Marwa Saadaoui, Duaa Ahmed Elhag, Sara Tomei, Mohammed Elanbari, Anthony K Akobeng, Amira Mustafa, Ibtihal Abdelgadir, Sharda Udassi, Mohammed A. Hendaus, Souhaila Al KhodorList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines10020278Publisher landing page
- PDF URL
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https://www.mdpi.com/2227-9059/10/2/278/pdf?version=1643350865Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/10/2/278/pdf?version=1643350865Direct OA link when available
- Concepts
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Vitamin D and neurology, Single-nucleotide polymorphism, Dysbiosis, vitamin D deficiency, Biology, Population, Internal medicine, Gut flora, Feces, Physiology, Vitamin, Calcitriol receptor, Endocrinology, Genotype, Medicine, Immunology, Genetics, Microbiology, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 6, 2022: 3Per-year citation counts (last 5 years)
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123Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.autoimmune | 27 |
| abstract_inverted_index.deficiency | 86, 339 |
| abstract_inverted_index.determined | 34 |
| abstract_inverted_index.displaying | 252 |
| abstract_inverted_index.diversity. | 256 |
| abstract_inverted_index.importance | 320 |
| abstract_inverted_index.inadequacy | 2, 117, 310 |
| abstract_inverted_index.inadequate | 185 |
| abstract_inverted_index.metabolic, | 24 |
| abstract_inverted_index.metabolite | 143 |
| abstract_inverted_index.microbiome | 328 |
| abstract_inverted_index.microbiota | 82 |
| abstract_inverted_index.nucleotide | 40 |
| abstract_inverted_index.population | 121 |
| abstract_inverted_index.strategies | 346 |
| abstract_inverted_index.transport, | 49 |
| abstract_inverted_index.Significant | 257 |
| abstract_inverted_index.composition | 152, 329 |
| abstract_inverted_index.considering | 322 |
| abstract_inverted_index.differences | 258 |
| abstract_inverted_index.enterotypes | 293 |
| abstract_inverted_index.metabolism, | 50 |
| abstract_inverted_index.microbiota, | 156 |
| abstract_inverted_index.microbiota. | 315 |
| abstract_inverted_index.prevalence, | 110 |
| abstract_inverted_index.rs12512631, | 197 |
| abstract_inverted_index.sequencing. | 165 |
| abstract_inverted_index.therapeutic | 348 |
| abstract_inverted_index.Bacteroides. | 302 |
| abstract_inverted_index.demonstrated | 291 |
| abstract_inverted_index.ethnicities. | 68 |
| abstract_inverted_index.implications | 113 |
| abstract_inverted_index.interpreting | 331 |
| abstract_inverted_index.personalized | 345 |
| abstract_inverted_index.Bacteroidetes | 270 |
| abstract_inverted_index.dissimilarity | 244 |
| abstract_inverted_index.inflammation. | 96 |
| abstract_inverted_index.non-deficient | 224, 239 |
| abstract_inverted_index.osteoporosis, | 20 |
| abstract_inverted_index.polymorphisms | 41 |
| abstract_inverted_index.significantly | 232, 311 |
| abstract_inverted_index.understanding | 107 |
| abstract_inverted_index.concentration, | 62 |
| abstract_inverted_index.concentrations | 31 |
| abstract_inverted_index.interventions. | 349 |
| abstract_inverted_index.cardiovascular, | 25 |
| abstract_inverted_index.deficiency/insufficiency | 171 |
| abstract_inverted_index.25-hydroxycholecalciferol | 147 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5025308944 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.77818113 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |