Tirzepatide-induced ketoacidosis in non-diabetic patients Article Swipe

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Pathan Mohamad Rafe Iqbal , Ossama Maadarani , Zouheir Bitar ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.12890/2024_004357

Background: Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients. Case description: We report the first case of ketoacidosis after the use of tirzepatide in an obese non-diabetic patient, secondary to the possibility of starvation ketoacidosis and insulin resistance. Conclusion: The dual-acting GLP-1 and GIP receptor agonists, tirzepatide, can induce ketoacidosis in obese non-diabetic patients.

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Medicine Diabetic ketoacidosis Ketoacidosis Internal medicine Endocrinology Starvation Agonist Insulin resistance Diabetes mellitus Glucagon-like peptide-1 Insulin Weight loss Obesity Receptor Type 2 diabetes Type 1 diabetes

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Type: article
Language: en
Landing Page: https://doi.org/10.12890/2024_004357
PDF: https://www.ejcrim.com/index.php/EJCRIM/article/download/4357/3891
OA Status: gold
Cited By: 9
References: 17
Related Works: 10
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DOI: https://doi.org/10.12890/2024_004357

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Title: Tirzepatide-induced ketoacidosis in non-diabetic patients

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Type: article

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Language: en

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Publication year: 2024

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Publication date: 2024-03-11

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Authors: Pathan Mohamad Rafe Iqbal, Ossama Maadarani, Zouheir Bitar

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Landing page: https://doi.org/10.12890/2024_004357

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Concepts: Medicine, Diabetic ketoacidosis, Ketoacidosis, Internal medicine, Endocrinology, Starvation, Agonist, Insulin resistance, Diabetes mellitus, Glucagon-like peptide-1, Insulin, Weight loss, Obesity, Receptor, Type 2 diabetes, Type 1 diabetes

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Cited by: 9

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Citations by year (recent): 2025: 6, 2024: 3

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abstract_inverted_index.possibility	48
abstract_inverted_index.resistance.	54
abstract_inverted_index.tirzepatide	39
abstract_inverted_index.description:	27
abstract_inverted_index.ketoacidosis	34, 51, 66
abstract_inverted_index.non-diabetic	24, 43, 69
abstract_inverted_index.tirzepatide,	63
abstract_inverted_index.glucagon-like	5
abstract_inverted_index.insulinotropic	8
abstract_inverted_index.1/glucose-dependent	7
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cited_by_percentile_year.min	96
countries_distinct_count	0
institutions_distinct_count	3
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.8299999833106995
sustainable_development_goals[0].display_name	Good health and well-being
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citation_normalized_percentile.is_in_top_10_percent	True